DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and Fermt1

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_932146.2	Gene:	Fermt1 / 241639	MGIID:	2443583	Length:	677	Species:	Mus musculus

Alignment Length:	728	Identity:	321/728 - (44%)
Similarity:	462/728 - (63%)	Gaps:	85/728 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SWNLRIFIT----DLALEKTMRVRGDQHIGGIMLQLVDPEN-PKDWSDHALWWPARNVWLSRTKL 67
            ||.|.:.:.    :...|.|:||.||.||||:||:||:..| .:||||:||||..:..||.:|..
Mouse    11 SWELVVRVDHANGEQQTEITLRVSGDLHIGGVMLKLVEQMNIAQDWSDYALWWEQKRCWLLKTHW 75

  Fly    68 TLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLCK 132
            |||:||||||:.|.|||.||:||::||:.:.:..||.:|...|.||.::||.|:||.||||||.|
Mouse    76 TLDKCGVQADANLLFTPQHKMLRLRLPNAKTVRLRVSFSAVVFKAVADICKVLNIRRPEELSLLK 140

  Fly   133 PLEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAPGS 197
            | .:::.|:.      :|:                :.||..|:.........|:.|...|.:||.
Mouse   141 P-SSDYCKKK------KKK----------------EKNSKEPVIEDILNLESSSTSSGSPVSPGL 182

  Fly   198 FFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGD---FQEN---LASSPPTPC 256
            :           :::...|..|..||...|.:.:         .||   .::|   ||.|.|.|.
Mouse   183 Y-----------SKTMTPTYDPINGTPALSTMTW---------FGDSPLTEQNCSVLAFSQPPPS 227

  Fly   257 ADVRALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQL 321
            .||.|...:|:|||:||::|.||||||.|:|||.|:|.:.|.|||||:||||||||.|.||||||
Mouse   228 PDVLADMFQPRSLVDKAKMNAGWLDSSRSLMEQSIQEDEQLQLRFKYYTFFDLNPKYDAVRINQL 292

  Fly   322 YEQAKWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQENDNEDEIDSALK 386
            ||||:|:||.||:||||||.|:|||||:    |:....|.|.:.. ..|.|:    .||:::||.
Mouse   293 YEQARWAVLLEEIDCTEEEMLIFAALQY----HISKLSQCAEIQD-FATKSE----VDEVEAALS 348

  Fly   387 ELQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRRV 451
            .|::||||........:||.||:|:|||:..:|::..|:..|:|:|.::|..:..|||.| ..:.
Mouse   349 SLEVTLEGGKADNTLEDITDIPKLADYLKLFRPKKLMLKACKQYWFVFKDTSIAYFKNKE-LEQG 412

  Fly   452 APAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRLAAKG 516
            .|...:||:|||:.||||:|..|:.|:|.:..  ..|:| ||::||::|.|||:|||||.||:||
Mouse   413 EPIEKLNLRGCEIVPDVNVSGRKFGIKLLIPV--ADGMN-EVYLRCDHEDQYARWMAACILASKG 474

  Fly   517 RSLADSSYESEVDSILSLLQMQRPAHGVHVNIDP---RSVEAVD-----YLSPKIIRKLSNKAV- 572
            :::|||||:.||.||||.|:|:      :.|..|   .|:|.:|     .:||...:|..:|.:
Mouse   475 KTMADSSYQPEVISILSFLKMK------NRNSSPLVASSLENMDMNPECLVSPCCAKKHKSKQLA 533

  Fly   573 QRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRMDLSSG 637
            .||||||.||.::..:::||::||||:|||:||::.::::|.|.:|:::||||:||::|:|..:|
Mouse   534 ARILEAHHNVAQMPLVEAKLQFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVAYNRLIRIDAVTG 598

  Fly   638 DHIKTWRYNTMKAWNVNWNIKCMMIQFEDENV--VFSCHSADCKVVHEFIGGYIFMSMRSKDTNQ 700
            ..:.|||:..||.|||||.|:.:.|:| |:||  .|:|.|||||:|||:||||||:|.||||.|:
Mouse   599 IPVTTWRFANMKQWNVNWEIRQVAIEF-DQNVSIAFTCLSADCKIVHEYIGGYIFLSTRSKDQNE 662

  Fly   701 TLNEELFHKLTGG 713
            ||:|:||||||||
Mouse   663 TLDEDLFHKLTGG 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	63/91 (69%)
		FERM_M	310..>365	CDD:278785	34/54 (63%)
		PH_fermitin	408..536	CDD:269943	59/127 (46%)
		PH	408..515	CDD:278594	46/106 (43%)
		FERM_M	<557..609	CDD:278785	24/57 (42%)
		FERM_C_fermitin	603..693	CDD:270026	46/91 (51%)
Fermt1	NP_932146.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..181		4/23 (17%)
		B41	<250..>322	CDD:214604	53/75 (71%)
		FERM_M	281..>322	CDD:278785	31/44 (70%)
		PH_fermitin	370..494	CDD:269943	59/127 (46%)
		PH	378..473	CDD:278594	41/98 (42%)
		FERM_M	<515..570	CDD:278785	23/54 (43%)
		FERM_C_fermitin	564..655	CDD:270026	46/91 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846763
Domainoid	1	1.000	300	1.000	Domainoid score	I1416
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	636	1.000	Inparanoid score	I832
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48345
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm8811
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760