Protein Alignment Fit2 and Fermt1

DIOPT Version :10

• Sequence 1: NP_648947.1
• Gene: Fit2 / 39907
• FlyBaseID: FBgn0036688
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_932146.2
• Gene: Fermt1 / 241639
• MGIID: 2443583
• Length: 677
• Species: Mus musculus
• Alignment Length: 728
• Identity: 321/728 - (44%)
• Similarity: 462/728 - (63%)
• Gaps: 85/728 - (11%)

  Fly     8 SWNLRIFIT----DLALEKTMRVRGDQHIGGIMLQLVDPEN-PKDWSDHALWWPARNVWLSRTKL 67
            ||.|.:.:.    :...|.|:||.||.||||:||:||:..| .:||||:||||..:..||.:|..
Mouse    11 SWELVVRVDHANGEQQTEITLRVSGDLHIGGVMLKLVEQMNIAQDWSDYALWWEQKRCWLLKTHW 75

  Fly    68 TLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLCK 132
            |||:||||||:.|.|||.||:||::||:.:.:..||.:|...|.||.::||.|:||.||||||.|
Mouse    76 TLDKCGVQADANLLFTPQHKMLRLRLPNAKTVRLRVSFSAVVFKAVADICKVLNIRRPEELSLLK 140

  Fly   133 PLEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAPGS 197
            | .:::.|:.      :|:                :.||..|:.........|:.|...|.:||.
Mouse   141 P-SSDYCKKK------KKK----------------EKNSKEPVIEDILNLESSSTSSGSPVSPGL 182

  Fly   198 FFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGD---FQEN---LASSPPTPC 256
            :           :::...|..|..||...|.:.:         .||   .::|   ||.|.|.|.
Mouse   183 Y-----------SKTMTPTYDPINGTPALSTMTW---------FGDSPLTEQNCSVLAFSQPPPS 227

  Fly   257 ADVRALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQL 321
            .||.|...:|:|||:||::|.||||||.|:|||.|:|.:.|.|||||:||||||||.|.||||||
Mouse   228 PDVLADMFQPRSLVDKAKMNAGWLDSSRSLMEQSIQEDEQLQLRFKYYTFFDLNPKYDAVRINQL 292

  Fly   322 YEQAKWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQENDNEDEIDSALK 386
            ||||:|:||.||:||||||.|:|||||:    |:....|.|.:.. ..|.|:    .||:::||.
Mouse   293 YEQARWAVLLEEIDCTEEEMLIFAALQY----HISKLSQCAEIQD-FATKSE----VDEVEAALS 348

  Fly   387 ELQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRRV 451
            .|::||||........:||.||:|:|||:..:|::..|:..|:|:|.::|..:..|||.| ..:.
Mouse   349 SLEVTLEGGKADNTLEDITDIPKLADYLKLFRPKKLMLKACKQYWFVFKDTSIAYFKNKE-LEQG 412

  Fly   452 APAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRLAAKG 516
            .|...:||:|||:.||||:|..|:.|:|.:..  ..|:| ||::||::|.|||:|||||.||:||
Mouse   413 EPIEKLNLRGCEIVPDVNVSGRKFGIKLLIPV--ADGMN-EVYLRCDHEDQYARWMAACILASKG 474

  Fly   517 RSLADSSYESEVDSILSLLQMQRPAHGVHVNIDP---RSVEAVD-----YLSPKIIRKLSNKAV- 572
            :::|||||:.||.||||.|:|:      :.|..|   .|:|.:|     .:||...:|..:|.:
Mouse   475 KTMADSSYQPEVISILSFLKMK------NRNSSPLVASSLENMDMNPECLVSPCCAKKHKSKQLA 533

  Fly   573 QRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRMDLSSG 637
            .||||||.||.::..:::||::||||:|||:||::.::::|.|.:|:::||||:||::|:|..:|
Mouse   534 ARILEAHHNVAQMPLVEAKLQFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVAYNRLIRIDAVTG 598

  Fly   638 DHIKTWRYNTMKAWNVNWNIKCMMIQFEDENV--VFSCHSADCKVVHEFIGGYIFMSMRSKDTNQ 700
            ..:.|||:..||.|||||.|:.:.|:| |:||  .|:|.|||||:|||:||||||:|.||||.|:
Mouse   599 IPVTTWRFANMKQWNVNWEIRQVAIEF-DQNVSIAFTCLSADCKIVHEYIGGYIFLSTRSKDQNE 662

  Fly   701 TLNEELFHKLTGG 713
            ||:|:||||||||
Mouse   663 TLDEDLFHKLTGG 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	FERM_F0_kindlins	8..86	CDD:340615	42/82 (51%)
		FERM_F1_kindlins	87..304	CDD:340616	74/222 (33%)
		B41	259..>351	CDD:214604	63/91 (69%)
		PH_fermitin	408..536	CDD:269943	59/127 (46%)
		FERM_M	<507..609	CDD:459788	49/110 (45%)
		FERM_C_fermitin	603..693	CDD:270026	46/91 (51%)
Fermt1	NP_932146.2	FERM_F0_KIND1	11..94	CDD:340700	42/82 (51%)
		Ubl1_cv_Nsp3_N-like	95..275	CDD:475130	74/222 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..181		4/23 (17%)
		B41	<250..>322	CDD:214604	53/75 (71%)
		PH_fermitin	370..494	CDD:269943	59/127 (46%)
		FERM_M	<453..570	CDD:459788	56/122 (46%)
		FERM_C_fermitin	564..655	CDD:270026	46/91 (51%)