DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and Fermt2

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_036014450.1	Gene:	Fermt2 / 218952	MGIID:	2385001	Length:	706	Species:	Mus musculus

Alignment Length:	747	Identity:	327/747 - (43%)
Similarity:	472/747 - (63%)	Gaps:	94/747 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENSWNLRIFITDLALEKTMRVRGDQHIGGIMLQLVDP-ENPKDWSDHALWWPARNVWLSRTKLTL 69
            :.:|.|.:.:|||..:.|:||.|:.||||:||:||:. :..||||||||||..:..||.:|..||
Mouse    15 DGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTL 79

  Fly    70 DQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLCKPL 134
            |:||:|||:.|.|||.||:||:|||:::|:..:|::|.:.|.||.::||..:||:||||||.|.
Mouse    80 DKCGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSLLKK- 143

  Fly   135 EAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFV--PISTSFHGEGGSTGSLDKPSAP-- 195
            ..:..|:...::..|......|.:| ..:.|.:.|:...  |:..|.:   .|.|...|...|
Mouse   144 PRDPTKKKKKKLDDQSEDEALELEG-PLIMPGSGTDVLYIGPLKGSIY---SSPGLYSKTMTPTY 204

  Fly   196 ----GSFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPC 256
                ||    ||||.:                        |.:..|:.|.|: ...||.|.|...
Mouse   205 DAHDGS----PLSPTS------------------------AWFGDSALSEGN-PGILAVSQPVTS 240

  Fly   257 ADVRALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQL 321
            .::.|...:|::|::||:.|.||||||.|:|||.::|.:.|.|||||::|||||||.|.:|||||
Mouse   241 PEILAKMFKPQALLDKAKTNQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQL 305

  Fly   322 YEQAKWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQENDNE----DEID 382
            ||||||::|.||::|||||.:||||||:.:|            ...|.||....:|.    ||:|
Mouse   306 YEQAKWALLLEEIECTEEEMMMFAALQYHIN------------KLSIMTSENHLNNSDKEVDEVD 358

  Fly   383 SALKELQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAED 447
            :||.:|:|||||........:||.||||:||::..||::.||:|||:|:.|::|..:..:|:.|:
Mouse   359 AALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSREE 423

  Fly   448 SRRVAPAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRL 512
            |.. .||..:||:|||||||||:|..|:.|:|.:..  ..|:| |:|:||:||:|||.|||||||
Mouse   424 SSG-TPAHQLNLRGCEVTPDVNISGQKFNIKLLIPV--AEGMN-EIWLRCDNEKQYAHWMAACRL 484

  Fly   513 AAKGRSLADSSYESEVDSILSLLQMQRPAHGVHVNIDPR--------SVEAVDYLSPKIIRKLSN 569
            |:||:::|||||..||.:|||.|:||      |:|.||:        .|.....:||:.::|..:
Mouse   485 ASKGKTMADSSYNLEVQNILSFLKMQ------HLNPDPQLIPDQITTDVNPECLVSPRYLKKYKS 543

  Fly   570 K----------------AVQRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRK 618
            |                ...||||||.||.:::.:::|:::||||:|||:||::.||.:|.|.::
Mouse   544 KQEKGCKKQMPGCVRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKR 608

  Fly   619 EELLGVAHNRIMRMDLSSGDHIKTWRYNTMKAWNVNWNIKCMMIQFEDE-NVVFSCHSADCKVVH 682
            |||:|:|:||::|||.|:||.|||||::.||.|||||.||.:.::|.|| .:.|.|...||||||
Mouse   609 EELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVH 673

  Fly   683 EFIGGYIFMSMRSKDTNQTLNEELFHKLTGGW 714
            ||||||||:|.|:||.|::|:||:|:|||.||
Mouse   674 EFIGGYIFLSTRAKDQNESLDEEMFYKLTSGW 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	56/91 (62%)
		FERM_M	310..>365	CDD:278785	30/54 (56%)
		PH_fermitin	408..536	CDD:269943	66/127 (52%)
		PH	408..515	CDD:278594	54/106 (51%)
		FERM_M	<557..609	CDD:278785	22/67 (33%)
		FERM_C_fermitin	603..693	CDD:270026	52/90 (58%)
Fermt2	XP_036014450.1	FERM_F0_KIND2	17..96	CDD:340701	42/78 (54%)
		FERM_F1_KIND2	97..288	CDD:340704	71/224 (32%)
		PH_fermitin	384..508	CDD:269943	66/127 (52%)
		FERM_M	<526..599	CDD:395297	23/72 (32%)
		PH-like	593..684	CDD:418428	52/90 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846764
Domainoid	1	1.000	300	1.000	Domainoid score	I1416
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4976
Inparanoid	1	1.050	636	1.000	Inparanoid score	I832
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48345
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm8811
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770