DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and unc-112

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_506628.1	Gene:	unc-112 / 179972	WormBaseID:	WBGene00006836	Length:	720	Species:	Caenorhabditis elegans

Alignment Length:	755	Identity:	330/755 - (43%)
Similarity:	463/755 - (61%)	Gaps:	75/755 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIHVGENS------WNLRIFITDLALEKTMRVRGDQHIGGIMLQLV---DPENPKDWSDHALWWP 56
            |.|:.|.:      |.|.|.:|||.:::::.|.|:.::||:||:||   |.|  :||||||||||
Worm     1 MAHLVEGTSIIDGKWQLPILVTDLNIQRSISVLGNLNVGGLMLELVSECDVE--RDWSDHALWWP 63

  Fly    57 ARNVWLSRTKLTLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLD 121
            .:..||..|:.||||.|:.|::.|.||||||..|:||||::.:|:|||:||.:|.|...||:.|.
Worm    64 EKRRWLQHTRSTLDQNGITAETQLEFTPMHKEARIQLPDMQMIDARVDFSVNSFKATKKLCRDLG 128

  Fly   122 IRYPEELSLCKPLEAEHLKRNFAQV-----PHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHG 181
            |||.|||||.:.:..|.|:|..:..     |...| |..|..|...|:.||      ||..|...
Worm   129 IRYSEELSLKRYIPPEDLRRGTSDADNMNGPLSMR-PGEESVGPMTLRKAA------PIFASQSN 186

  Fly   182 ----EGGSTGSLDKPSAPGSFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLG 242
                ..|.:.:|   |..|..|.|.......|..:..|.|||.||.:..:........|.|.|.|
Worm   187 LDMRRRGQSPAL---SQSGHIFNAHEMGTLPRHGTLPRGVSPSPGAYNDTMRRTPIMPSISFSEG 248

  Fly   243 ----DFQENLASSPP-TPCADVRALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFK 302
                .|.:.|..||. .|..|...  .||::.||||.:|.||||||.|:|||||.|.|.:.||||
Worm   249 LENEQFDDALIHSPRLAPSRDTPV--FRPQNYVEKAAINRGWLDSSRSLMEQGIFEGDIILLRFK 311

  Fly   303 YFTFFDLNPKCDQVRINQLYEQAKWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSG 367
            :..|||||||.|.|||||||||||||:|.:|.|.||||:.:|||||.|.....| :|:
Worm   312 FMNFFDLNPKYDPVRINQLYEQAKWSILLDEFDHTEEEATLFAALQLQATLQRD-SPE------- 368

  Fly   368 IETSSQENDNEDEIDSALKELQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRF-TLRGYKRYY 431
                 .|.:|:|::|..|.||:..|:.......| ::|::|||:|||:|:||::. ..:|:||.:
Worm   369 -----PEENNKDDVDILLDELEQNLDAAALNRRS-DLTQVPELADYLKYMKPKKLAAFKGFKRAF 427

  Fly   432 FTYRDLHLHLFKNAEDSRRVAPAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVR 496
            |::|||:|...:::.|... ||....:||||||:.||::.|.||.|:|.:....|   ..:..::
Worm   428 FSFRDLYLSYHQSSSDVNS-APLGHFSLKGCEVSQDVSVGQQKYHIKLLLPTAEG---MIDFILK 488

  Fly   497 CENEQQYAKWMAACRLAAKGRSLADSSYESEVDSILSLLQMQ--------------RPAHGVHVN 547
            |::|.|||:||||||||::|:|:|||||:.||:||.:||:||              |.|..|.:
Worm   489 CDSEHQYARWMAACRLASRGKSMADSSYQQEVESIKNLLKMQSGNGNENGNSNTASRKAAAVKL- 552

  Fly   548 IDPRSVEAVDYLSPKIIRKLSNK--AVQRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFI 610
              |......:|:|.|.:|:..:|  ..||:.:||.|||:|.|.::||:||:||::||:.|:..||
Worm   553 --PNDFNVDEYISSKYVRRARSKQQIQQRVSDAHGNVRQLTATEAKLQYIRAWQALPEHGIHYFI 615

  Fly   611 IKFDGHRKEELLGVAHNRIMRMDLSSGDHIKTWRYNTMKAWNVNWNIKCMMIQFEDENVVFSCHS 675
            ::|...||.||:.||.||:.::::.:|:.:||||:..||.|:|||.|:.:.||||||::.|...|
Worm   616 VRFRNARKAELVAVAVNRLAKLNMDNGESLKTWRFANMKKWHVNWEIRHLKIQFEDEDIEFKPLS 680

  Fly   676 ADCKVVHEFIGGYIFMSMRSKDTNQTLNEELFHKLTGGWS 715
            |||||||||||||||:|||||:.:|.|:|||||||||||:
Worm   681 ADCKVVHEFIGGYIFLSMRSKEHSQNLDEELFHKLTGGWA 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	58/91 (64%)
		FERM_M	310..>365	CDD:278785	32/54 (59%)
		PH_fermitin	408..536	CDD:269943	59/128 (46%)
		PH	408..515	CDD:278594	47/107 (44%)
		FERM_M	<557..609	CDD:278785	23/53 (43%)
		FERM_C_fermitin	603..693	CDD:270026	47/89 (53%)
unc-112	NP_506628.1	B41	<286..>371	CDD:214604	54/97 (56%)
		FERM_M	319..>371	CDD:278785	32/64 (50%)
		PH_fermitin	403..528	CDD:269943	59/128 (46%)
		PH	411..507	CDD:278594	41/99 (41%)
		FERM_M	<556..614	CDD:278785	23/57 (40%)
		FERM_C_fermitin	608..698	CDD:270026	47/89 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164181
Domainoid	1	1.000	246	1.000	Domainoid score	I1198
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4976
Inparanoid	1	1.050	577	1.000	Inparanoid score	I554
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48345
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		otm14270
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810