DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and Fermt3

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001349328.1	Gene:	Fermt3 / 108101	MGIID:	2147790	Length:	665	Species:	Mus musculus

Alignment Length:	736	Identity:	295/736 - (40%)
Similarity:	433/736 - (58%)	Gaps:	115/736 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENSWNLRIFITD---LALEKTMRVRGDQHIGGIMLQLVDPENPK-DWSDHALWWPARNVWLSRTK 66
            ::||.||:|:.:   .|...|:||.|:.||||::|::|:..|.| ||||||:||..:..||.:|.
Mouse    13 DSSWELRVFVGEEDPEAQSVTLRVTGESHIGGVLLKIVEEINRKQDWSDHAIWWEQKRQWLLQTH 77

  Fly    67 LTLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLC 131
            .|||:.|:.||:.|.|.|.|:.:.::||:.|.|..|..:|...|..|..:|:.|.||:||||||.
Mouse    78 WTLDKYGILADARLFFGPQHRPVILRLPNRRVLRLRASFSKPLFQTVAAICRLLSIRHPEELSLL 142

  Fly   132 KPLEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAPG 196
            :..|.:..|:       :::.|..|....|.:..|...     ..|.|.|
Mouse   143 RAPEKKEKKK-------KEKEPEEEVHDLTKVVLAGGV-----APTLFRG--------------- 180

  Fly   197 SFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADVRA 261
                                   .|..:..|....|.|...|.             |.|..|...
Mouse   181 -----------------------MPAHFSDSAQTEACYHMLSR-------------PQPAPDPLL 209

  Fly   262 LQL--RPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQLYEQ 324
            ||.  ||.||.:|.:|:..|||||..:|:|||:..|.|.|||||::||||:||.|.||:.|||||
Mouse   210 LQRLPRPSSLPDKTQLHSRWLDSSRCLMQQGIKAGDVLWLRFKYYSFFDLDPKTDPVRLTQLYEQ 274

  Fly   325 AKWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQG--AAVDSGIETSSQENDNEDEIDSALKE 387
            |:|.:|.||:||||||.::|||||:.:|........|  |:.|.|:          |::|:||..
Mouse   275 ARWDLLTEEIDCTEEEMMVFAALQYHINKLTLSGDVGELASGDLGL----------DDLDAALNN 329

  Fly   388 LQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRRVA 452
            |::.|:|........::|.||||.|:||..:|::.||:||::|:..::|..|..:| ::|.....
Mouse   330 LEVKLKGSAPSDMLDSLTTIPELKDHLRIFRPRKLTLKGYRQYWVVFKDTTLSYYK-SQDEAPGD 393

  Fly   453 PAISINLKGCEVTPDVNLSQGKYAIRLEV-SPDGGHGINSEVWVRCENEQQYAKWMAACRLAAKG 516
            |...:|||||||.||||:|..|:.|:|.| ||:|    .||:::||::|||||:||||||||:||
Mouse   394 PTQQLNLKGCEVVPDVNVSGQKFCIKLLVPSPEG----MSEIYLRCQDEQQYAQWMAACRLASKG 454

  Fly   517 RSLADSSYESEVDSILSLLQMQR-----------------PAHGVHVNIDPRSVEAVDYLSPKII 564
            |::|||||.|||.:||:.|.:||                 ||.|    ::|..:     ::|:..
Mouse   455 RTMADSSYASEVQAILAFLSLQRAGGSNGGSGNKPQGPEAPAEG----LNPYGL-----VAPRFQ 510

  Fly   565 RKLSNKAV-QRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNR 628
            ||...|.: .||||||.||.:|:..:::|::||||:||||||:|..:::|.|.||:|:||:|:||
Mouse   511 RKFKAKQLTPRILEAHQNVAQLSLTEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEILGIANNR 575

  Fly   629 IMRMDLSSGDHIKTWRYNTMKAWNVNWNIKCMMIQFEDE-NVVFSCHSADCKVVHEFIGGYIFMS 692
            ::|:||:.||.:||||::.|:.|||||:|:.:.|:|::. ||.|||.||.|::|||:||||||:|
Mouse   576 LIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLS 640

  Fly   693 MRSKDTNQTLNEELFHKLTGG 713
            .|.:...:.|:|:||.:||||
Mouse   641 TRERARGEELDEDLFLQLTGG 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	54/93 (58%)
		FERM_M	310..>365	CDD:278785	29/56 (52%)
		PH_fermitin	408..536	CDD:269943	66/128 (52%)
		PH	408..515	CDD:278594	53/107 (50%)
		FERM_M	<557..609	CDD:278785	25/52 (48%)
		FERM_C_fermitin	603..693	CDD:270026	49/90 (54%)
Fermt3	NP_001349328.1	B41	<221..>301	CDD:214604	48/79 (61%)
		PH_fermitin	350..474	CDD:269943	66/128 (52%)
		FERM_M	<490..555	CDD:306805	28/73 (38%)
		FERM_C_fermitin	550..641	CDD:270026	49/90 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846765
Domainoid	1	1.000	300	1.000	Domainoid score	I1416
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	636	1.000	Inparanoid score	I832
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm8811
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760