DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and fermt1

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_002665831.3	Gene:	fermt1 / 100332544	ZFINID:	ZDB-GENE-030131-3264	Length:	661	Species:	Danio rerio

Alignment Length:	728	Identity:	308/728 - (42%)
Similarity:	448/728 - (61%)	Gaps:	84/728 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIHVGE--NSWNLRIFIT----DLALEKTMRVRGDQHIGGIMLQLVDP-ENPKDWSDHALWWPAR 58
            |...||  ::|.|.|.:.    |..:...:||:||.|:||:||:||:. :.|:||||||:||..:
Zfish     1 MASAGEHGHTWELSIQVDQREGDEGMRFKLRVKGDLHVGGLMLKLVEKIKAPQDWSDHAIWWEQK 65

  Fly    59 NVWLSRTKLTLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIR 123
            :.||.:|..|||:.|:||::.|.:||.||.|.:|||:::.:...|.:|...|.||..:||.|:||
Zfish    66 SCWLLKTHWTLDKYGIQANADLRYTPQHKSLCIQLPNMKNIKLPVTFSGVVFRAVAEICKTLNIR 130

  Fly   124 YPEELSLCKPLEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGS 188
            ..|||||.||.:.          |.:|:    :.|..|.|  |.|....:.|:      ||:.|.
Zfish   131 RTEELSLLKPTDE----------PKKKK----KKDKGTDL--ATDEILTMDIT------GGALGM 173

  Fly   189 LDKPSAPGSFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPP 253
            ..|...|         .::..:.|||.:.|.:.|               .|.|...|.||   ||
Zfish   174 YSKTMTP---------IYDPDSGSPVSSTSLWYG---------------GSPLTACQPNL---PP 211

  Fly   254 TPCADVRALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRI 318
            ...|.:    .:|.::.:||.:|.||||||.|:|||||:|.|.|.|||||..|||||||.|.|||
Zfish   212 EELAKL----YKPLTMEDKAAINAGWLDSSRSLMEQGIQENDRLLLRFKYHCFFDLNPKYDAVRI 272

  Fly   319 NQLYEQAKWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQENDNE---DE 380
            .||||||:|::|.||:||||||.||||:||:.:            ....:.|...:|.:|   ||
Zfish   273 TQLYEQARWAILLEEIDCTEEEMLMFASLQYHI------------CKLTLSTEPLDNSDEKEVDE 325

  Fly   381 IDSALKELQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNA 445
            :::||..|:..|||.:......:||.||:|.|.|:..:|:|.||:.||.|:|.:||..:..|||
Zfish   326 VEAALSNLETHLEGRNADKILEDITDIPKLEDTLKLFRPKRLTLKPYKEYWFVFRDTTISYFKN- 389

  Fly   446 EDSRRVAPAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAAC 510
            :||....|...::|:||||.||||:::.|:.::|.:  ....|:| ||::|||||.|||||.|||
Zfish   390 KDSANKEPIEQLHLRGCEVIPDVNVTERKFGLKLLL--PAADGMN-EVYIRCENETQYAKWKAAC 451

  Fly   511 RLAAKGRSLADSSYESEVDSILSLLQMQR---PAHGVHVNIDPRSVEAVDYLSPKIIRKLSNKAV 572
            .||:||:::|.|||.:||.:|.|.|||:.   |......:::...:....::||:..:|...|.:
Zfish   452 ILASKGKTMAYSSYRTEVKNIQSFLQMKSLAPPPGQAAPDVESMEMNPECFVSPRYAKKFKTKQL 516

  Fly   573 -QRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRMDLSS 636
             .||||||.|:.:|:.:::|:::||||:||||||:..:|::|.|.:|:||||:::||::|:|:|:
Zfish   517 TTRILEAHHNISQLSLMEAKMRFIQAWQSLPDFGIKYYIVRFRGSKKDELLGISYNRLIRIDMST 581

  Fly   637 GDHIKTWRYNTMKAWNVNWNIKCMMIQFEDE-NVVFSCHSADCKVVHEFIGGYIFMSMRSKDTNQ 700
            |..:.|||::.||.|||||.|:.:.|:|:.. ::.|||.|.|||||||:||||||:|.||||.|:
Zfish   582 GLPVTTWRFSNMKQWNVNWEIRQVTIEFDQSVSIAFSCQSCDCKVVHEYIGGYIFLSTRSKDQNE 646

  Fly   701 TLNEELFHKLTGG 713
            ||:||||||||||
Zfish   647 TLDEELFHKLTGG 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	57/91 (63%)
		FERM_M	310..>365	CDD:278785	29/54 (54%)
		PH_fermitin	408..536	CDD:269943	60/127 (47%)
		PH	408..515	CDD:278594	50/106 (47%)
		FERM_M	<557..609	CDD:278785	23/52 (44%)
		FERM_C_fermitin	603..693	CDD:270026	47/90 (52%)
fermt1	XP_002665831.3	B41	<221..>321	CDD:214604	58/111 (52%)
		FERM_M	264..>307	CDD:278785	29/54 (54%)
		PH-like	353..477	CDD:302622	60/127 (47%)
		PH	361..456	CDD:278594	46/98 (47%)
		FERM_M	<499..554	CDD:278785	23/54 (43%)
		FERM_C_fermitin	548..639	CDD:270026	47/90 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591972
Domainoid	1	1.000	297	1.000	Domainoid score	I1426
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	630	1.000	Inparanoid score	I825
OMA	1	1.010	-	-		QHG48345
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm6417
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770