DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and im:7154036

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_021332356.1	Gene:	im:7154036 / 100320305	ZFINID:	ZDB-GENE-080917-11	Length:	641	Species:	Danio rerio

Alignment Length:	712	Identity:	295/712 - (41%)
Similarity:	434/712 - (60%)	Gaps:	83/712 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SWNLRIFITDL---ALEKTMRVRGDQHIGGIMLQLVDPEN-PKDWSDHALWWPARNVWLSRTKLT 68
            :|:|.|.:.:|   |....:.|..|.||||::|::|:... .||||||||||..:..||.:...|
Zfish     3 AWDLSIMVEELGPQAPPLKISVTSDLHIGGVILKVVEKSQIKKDWSDHALWWEQKQQWLLKPSWT 67

  Fly    69 LDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLCKP 133
            ||:||:.||:.|..||.||.||:.:|:...:..||.:|...|..|:.:||.|:||:||||||..|
Zfish    68 LDKCGIHADARLCLTPQHKPLRLLMPNAITVCMRVCFSNPVFRTVMGICKVLNIRHPEELSLLWP 132

  Fly   134 LEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAPGSF 198
            :|.:..|::                        .|....|...||
Zfish   133 VEEKKKKKD------------------------KDVGEEVYDITS-------------------- 153

  Fly   199 FCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADVRALQ 263
              |||.     :.:.::..:..|..:.::....|.|           :.||.|.|.|..::.|..
Zfish   154 --APLP-----SSTILKLANGMPAFFAETPESEAVY-----------KMLAVSQPPPAPEIIAKT 200

  Fly   264 LRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQLYEQAKWS 328
            .|..:::|||::|..|||||.|:::||::|.|.|.|||||::|.|:.|:.|.||:.||||||:|:
Zfish   201 YRSTNIMEKAQINGRWLDSSRSLLQQGVKENDKLILRFKYYSFHDVIPQSDVVRLTQLYEQARWA 265

  Fly   329 VLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQENDNEDEIDSALKELQITLE 393
            :|.||::|||||.::|||||:.:. .|..|.|..|....:          |::||||:.|::.:|
Zfish   266 ILLEEIECTEEEMMVFAALQYHIG-KVSLTEQLVASCPAM----------DDLDSALQCLEVKME 319

  Fly   394 GPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRRVAPAISIN 458
            |.....|.......|||.|||:..:|:|.||:|||:|:||::|..:..:|:.|:|.: .|...:|
Zfish   320 GESSADDMLETMTAPELHDYLKIFRPKRLTLKGYKQYWFTFKDTTISYYKSKEESCK-EPIQQMN 383

  Fly   459 LKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRLAAKGRSLADSS 523
            ||||||.|||:::..|:.|||.:  .|..|:| ||::|||:||||::||||||||:||::|||||
Zfish   384 LKGCEVAPDVSVAGQKFCIRLLI--PGPEGMN-EVYLRCEHEQQYSRWMAACRLASKGKTLADSS 445

  Fly   524 YESEVDSILSLLQMQRPAHGVHVNIDPRSVEAVDYLSPKIIRKLSNKAV-QRILEAHANVRELNA 587
            :.:||.||.|.|.||:.....:......|:.....:||:..:|...|.: .|||||:.||.:|:.
Zfish   446 FSNEVQSIQSFLAMQKTTPSNNTAQTDESINTHSLVSPRYQKKYKPKQLTPRILEAYQNVAQLSL 510

  Fly   588 LDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRMDLSSGDHIKTWRYNTMKAWN 652
            .|:..|::|.|::|||||:|..:::|.|.||:|:||:|:||::|:|||.||.:||||||||:.||
Zfish   511 TDAIQKFLQIWQALPDFGLSYIVVRFKGCRKDEVLGIANNRLIRIDLSVGDVVKTWRYNTMRQWN 575

  Fly   653 VNWNIKCMMIQFE-DENVVFSCHSADCKVVHEFIGGYIFMSMRSKDTNQTLNEELFHKLTGG 713
            |||:||.:.|:|: :.|:.|||.:||||:|||:||||||||.|.:|.:.|||||||||||||
Zfish   576 VNWDIKQVAIEFDGNVNIAFSCVTADCKIVHEYIGGYIFMSTRGRDQSDTLNEELFHKLTGG 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	48/91 (53%)
		FERM_M	310..>365	CDD:278785	28/54 (52%)
		PH_fermitin	408..536	CDD:269943	67/127 (53%)
		PH	408..515	CDD:278594	55/106 (52%)
		FERM_M	<557..609	CDD:278785	22/52 (42%)
		FERM_C_fermitin	603..693	CDD:270026	55/90 (61%)
im:7154036	XP_021332356.1	FERM_B-lobe	<216..>288	CDD:324381	42/71 (59%)
		PH_fermitin	334..458	CDD:269943	67/127 (53%)
		FERM_M	<466..531	CDD:306805	22/64 (34%)
		FERM_C_fermitin	526..617	CDD:270026	55/90 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591973
Domainoid	1	1.000	297	1.000	Domainoid score	I1426
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	630	1.000	Inparanoid score	I825
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm6417
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760