DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and fermt2

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_031747907.1	Gene:	fermt2 / 100124904	XenbaseID:	XB-GENE-1012566	Length:	721	Species:	Xenopus tropicalis

Alignment Length:	738	Identity:	331/738 - (44%)
Similarity:	475/738 - (64%)	Gaps:	84/738 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENSWNLRIFITDLALEKTMRVRGDQHIGGIMLQLVDP-ENPKDWSDHALWWPARNVWLSRTKLTL 69
            :.:|.|.|.:|||..:.|:||.|:.||||:||:||:. :..||||||||||..:..||.:|..||
Frog    38 DGTWELNIHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTL 102

  Fly    70 DQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLC-KP 133
            |:.|:|||:.|.|||.||:||:|||:::|:..:|::|.|.|.||.::||..:||:||||||. ||
Frog   103 DKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDKVFKAVSDICKTFNIRHPEELSLLRKP 167

  Fly   134 LEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFV--PISTSFHGEGGSTGSLDKPSAPG 196
            .:....|:.  ::..|....|.|.:| ..|.|.:.|:...  |:..|.:            |:||
Frog   168 RDPTKKKKK--KIDDQCEDNILELEG-PLLTPGSGTDVLYIGPVKGSIY------------SSPG 217

  Fly   197 SFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADVRA 261
            .:.......::.|..||:...|             |.:..|:.|.|: ...||.|.|....::.|
Frog   218 LYSKTMTPTYDSRDGSPLSPTS-------------AWFGDSALSEGN-PGILAVSQPITSPEILA 268

  Fly   262 LQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQLYEQAK 326
            ...:|::|::||::|.|||||:.|:|||.::|.|.|.|||||::|||||||.|.:||||||||||
Frog   269 KMYKPQTLLDKAKINQGWLDSARSLMEQDVKENDALLLRFKYYSFFDLNPKYDAIRINQLYEQAK 333

  Fly   327 WSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQEN-----DNE-DEIDSAL 385
            |::|.||::|||||.:||||||:.:|.              :...|.||     |.| ||:|:||
Frog   334 WAILLEEIECTEEEMMMFAALQYHINK--------------LSVMSSENHYNNSDKEVDEVDAAL 384

  Fly   386 KELQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRR 450
            .:|:|||||........:||.||||:|||:..||::.||:|||:|:.|::|..:..:|:.|:|..
Frog   385 SDLEITLEGGKTSTILGDITSIPELTDYLKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESNG 449

  Fly   451 VAPAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRLAAK 515
             .||..:||:|||||||||:|..|:.|:|.:..  ..|:| |:|:|||||:|||.||||||||:|
Frog   450 -TPAHQMNLRGCEVTPDVNISGQKFNIKLLIPV--AEGMN-EIWLRCENEKQYAHWMAACRLASK 510

  Fly   516 GRSLADSSYESEVDSILSLLQMQRPAHGVHVNIDPRSV----------EAVDYLSPKIIRKLSNK 570
            |:::|||||..||.:|||.|:||      |:|.||:.:          |.|  :||:.::|..||
Frog   511 GKTMADSSYNLEVQNILSFLKMQ------HLNPDPQFIPDQVNSDINPECV--VSPRYLKKYKNK 567

  Fly   571 --------AVQRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHN 627
                    ...||||||.||.:::.:::|:::||||:|||:||::.|:.:|.|.:||||:|:.:|
Frog   568 QPGYVRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLARFQGGKKEELIGITYN 632

  Fly   628 RIMRMDLSSGDHIKTWRYNTMKAWNVNWNIKCMMIQFEDE-NVVFSCHSADCKVVHEFIGGYIFM 691
            |::|||..:||.|||||::.||.|||||.||.:.::|.|| .:.|.|...||||||||||||||:
Frog   633 RLIRMDAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEMRLSFICAEVDCKVVHEFIGGYIFL 697

  Fly   692 SMRSKDTNQTLNEELFHKLTGGW 714
            |.|:||.|::|:||:|.|||.||
Frog   698 STRAKDQNESLDEEMFFKLTSGW 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	56/91 (62%)
		FERM_M	310..>365	CDD:278785	30/54 (56%)
		PH_fermitin	408..536	CDD:269943	68/127 (54%)
		PH	408..515	CDD:278594	56/106 (53%)
		FERM_M	<557..609	CDD:278785	23/59 (39%)
		FERM_C_fermitin	603..693	CDD:270026	50/90 (56%)
fermt2	XP_031747907.1	FERM_F0_KIND2	40..119	CDD:340701	42/78 (54%)
		FERM_F1_KIND2	120..311	CDD:340704	72/219 (33%)
		B41	<278..>358	CDD:214604	53/79 (67%)
		PH_fermitin	407..531	CDD:269943	68/127 (54%)
		FERM_M	<518..614	CDD:395297	39/103 (38%)
		PH-like	608..699	CDD:418428	50/90 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	296	1.000	Domainoid score	I1456
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4976
Inparanoid	1	1.050	633	1.000	Inparanoid score	I827
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm9477
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060