Protein Alignment CG6652 and Lca5

DIOPT Version :10

• Sequence 1: NP_648946.3
• Gene: CG6652 / 39905
• FlyBaseID: FBgn0036687
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_081724.1
• Gene: Lca5 / 75782
• MGIID: 1923032
• Length: 704
• Species: Mus musculus
• Alignment Length: 681
• Identity: 140/681 - (20%)
• Similarity: 266/681 - (39%)
• Gaps: 152/681 - (22%)

  Fly     8 ASSYGPRVSQSEPNNLMAASAKSCESLFSASSRE-------SASLIY----QRSKPPPPQQRGGV 61
            :|.:|.....|.|::  ..:...|     ||:||       |.:.::    ::..|.....:.|:
Mouse    25 SSDFGSSPQSSGPSS--PVNTTPC-----ASTREKNPKRHLSDNQVHHPTVRKVSPKAVPSKKGI 82

  Fly    62 KGSGSMSSQNHSEIH-------QRVMSARNLRAKTFQNQLADAQAEIANLAHENRMLRTLHNRQS 119
            :......|.|...:.       :||:|||.|:....||::::.|.::|.|..||:.|::|..||.
Mouse    83 RVGFRSQSLNREPLRKDPDIVTKRVLSARLLKINELQNEVSELQVKLAQLLKENKALKSLQYRQE 147

  Fly   120 SALNKYEAHNAELPKLLSSHAEELRMWQTKYRKLQAANKALELKLKQKEEIILTLSDQNKHYSQL 184
            .||||:|....|:.:|:..|..|:...:.:.||.|...:|.|.::|:.|..:.......:...::
Mouse   148 KALNKFEDAENEISQLIHRHNNEITALKERLRKSQEKERATEKRVKETEGELFRTKFSLQKLKKI 212

  Fly   185 NKDKNLDERQKLQEKLKSLEQRLEEKDNDMKLMARKVQLESKNIRQQLLNEQRKGKEV-----ML 244
            ::.::|.||..|.:||.|.|.:|::.:..:|.:::.::|.:.:.::|||.|:::..|.     :|
Mouse   213 SEARHLPERDDLAKKLVSAELKLDDTERKIKELSKNLELSTNSFQRQLLAERKRAFEAYDENKVL 277

  Fly   245 KLEKAKLEISGYRKLEEYTLGTDKVN------PLSSGRRTK---LSGVTDEPDKIDKLEKSM--- 297
            :.|..:|    :.||:|.....|..|      |.||.::.|   ...|:.:.|..|:..|.:
Mouse   278 QKELQRL----HHKLKEKEKELDIKNIYANRLPKSSPKKEKEIERKHVSCQSDFTDQCTKGVQTA 338

  Fly   298 -------------------------EMLDKAIEKN--NQSEFTALTDVMESESFYDFEKDSAEDK 335
                                     |.|...:|..  |:.....|:.|:..|..||.::|....|
Mouse   339 EDFELEDFPFTAQTVLCYENRWDEPEYLSSYLEYQDLNKHGSEMLSSVLGQEGKYDEDEDPCSAK 403

  Fly   336 SGPNTPPSQIERQ----------VGGRGGKLILP----PATNHA-----KMGQKANRSTLSQVLS 381
            .....|.|:..|:          :.||..||.|.    |..|:.     |...:|.|.....:|:
Mouse   404 QEARKPESEWAREELDKVKGKSALLGRAEKLALEAGRFPTENYQAQSVDKFEDEAERLKTEMLLA 468

  Fly   382 AQGKISVSSGKSAKSRIAVAVPKMESVQVSKRREPETVSR-----LASAETK---PKQKPLEYEY 438
            ...:|:                       .:.::|:.:.|     |.:.|:|   |.:....|.:
Mouse   469 KLNEIN-----------------------KELQDPQNLGRAPLPLLPNFESKLHSPDRSTRPYSF 510

  Fly   439 EDDYEPA--GEDGDDDAYGMMSKMCEGEEP-------QDNSEENANESSLLKYSAYMDNKSSEGD 494
            .:..:.:  |:...|.::  ::...||..|       |..|....:|.|...|.........:.:
Mouse   511 PESLDRSFNGQHLQDLSF--LTPRGEGGSPGPIRSPGQIRSPAPLDEFSFGSYVPSFGKTLGKSN 573

  Fly   495 PLEESMEEYD-GTDGQQSQGSDDEDISVRAPRLKENMSSLRKQISNDFKERESFLKTFCRQASNS 558
            |..:.....| .::..:|...|..|:..|    ||..::|.:|:             |...|||:
Mouse   574 PPSQKSSLLDFQSNSSESPSKDSLDLMSR----KEKKATLMEQL-------------FGPSASNT 621

  Fly   559 NMRDDSASKKRNSIATGAAASSHMTGSRKNA 589
            ::...|......:.:.|.....|.....:|:
Mouse   622 SVSSKSTDPHFPAASRGDMDPLHFLSGDRNS 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6652	NP_648946.3	Lebercilin	75..261	CDD:464776	54/197 (27%)
Lca5	NP_081724.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..80		11/61 (18%)
		Lebercilin	103..295	CDD:464776	55/195 (28%)
		SMC_prok_B	<114..478	CDD:274008	85/390 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..417		8/27 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..661		35/196 (18%)