DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6652 and LCA5

DIOPT Version :9

Sequence 1:	NP_648946.3	Gene:	CG6652 / 39905	FlyBaseID:	FBgn0036687	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001116241.1	Gene:	LCA5 / 167691	HGNCID:	31923	Length:	697	Species:	Homo sapiens

Alignment Length:	653	Identity:	152/653 - (23%)
Similarity:	266/653 - (40%)	Gaps:	128/653 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NNLMAASAKSCESLFSASSRESASLIYQRSKPPPPQ---QRGGVKGSGSMSSQNHSEIH------ 76
            ::|:::|..|..............:.:|..:.|.|:   .|.||:......|.|...:.
Human    36 SSLVSSSPASVRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLV 100

  Fly    77 -QRVMSARNLRAKTFQNQLADAQAEIANLAHENRMLRTLHNRQSSALNKYEAHNAELPKLLSSHA 140
             :|::|||.|:....||::::.|.::|.|..||:.|:.|..||..||||:|....|:.:|:..|.
Human   101 TKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHN 165

  Fly   141 EELRMWQTKYRKLQAANKALELKLKQKEEIILTLSDQNKHYSQLNKDKNLDERQKLQEKLKSLEQ 205
            .|:...:.:.||.|...:|.|.::|..|..:.......:...::::.::|.||..|.:||.|.|.
Human   166 NEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAEL 230

  Fly   206 RLEEKDNDMKLMARKVQLESKNIRQQLLNEQRKGKEV-----MLKLEKAKLEISGYRKLEEYTLG 265
            :|::.:..:|.:::.::|.:.:.::|||.|:::..|.     :|:.|..:|    |.||:|....
Human   231 KLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRL----YHKLKEKERE 291

  Fly   266 TDKVNPLSSGRRTKLSGVTDEPDKIDKLEKSMEMLDKAIEKNN--QSEFTAL----TDVMESESF 324
            .| :..:.|.|..|.|     |:|    ||.:     |:.||.  ||:|..|    ...||
Human   292 LD-IKNIYSNRLPKSS-----PNK----EKEL-----ALRKNAACQSDFADLCTKGVQTME---- 337

  Fly   325 YDFEKDSAEDKSGPNTPPS-QIERQVGGRGGKLILPPATNHAKMGQKANRSTLSQVLSAQGKISV 388
             ||:.:..     |.||.: ..........|.|.|.  ....|..:......|:.::..:.|...
Human   338 -DFKPEEY-----PLTPETIMCYENKWEEPGHLTLD--LQSQKQDRHGEAGILNPIMEREEKFVT 394

  Fly   389 SSGKSAKSRIAVAVPKMESVQVSKRREPETVSRLASAETKPKQKPLEYEYEDDYEPAGEDGDDDA 453
            .      ..:.|...::|.::....||          |...|||......|.:.:|..|.|   .
Human   395 D------EELHVVKQEVEKLEDEWERE----------ELDKKQKEKASLLEREEKPEWETG---R 440

  Fly   454 Y--GM-----MSKMCEGEEPQ-----------DNSEENANESSLLKYSA---YMDNKSSEGDPLE 497
            |  ||     |.|: :|||.:           :..:....:|..|||..   ..|.:|....| |
Human   441 YQLGMYPIQNMDKL-QGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSP-E 503

  Fly   498 ESMEEYDGTDGQQS--QGSDDEDISVRAPRLK-ENMSSLR--------------------KQISN 539
            .|.:.|..::..:.  .|...:|||...|:.: :|..::|                    .:.||
Human   504 RSPKTYRFSESSERLFNGHHLQDISFSTPKGEGQNSGNVRSPASPNEFAFGSYVPSFAKTSERSN 568

  Fly   540 DFKERESFLKTFCRQASNSNMRD-----DSASKKRNSIAT--GAAASSHMT--GSRKNALLAALK 595
            .|.::.||| .|.|.:.....:|     ....||.|.:..  ||:.||.::  .|..|::.::..
Human   569 PFSQKSSFL-DFQRNSMEKLSKDGVDLITRKEKKANLMEQLFGASGSSTISSKSSDPNSVASSKG 632

  Fly   596 TID 598
            .||
Human   633 DID 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6652	NP_648946.3	Lebercilin	82..257	CDD:292252	49/179 (27%)
		GBP_C	<151..252	CDD:303769	25/105 (24%)
		coiled coil	239..250	CDD:293879	3/15 (20%)
LCA5	NP_001116241.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90		10/53 (19%)
		Neuromodulin_N	<90..482	CDD:331332	104/442 (24%)
		Lebercilin	107..286	CDD:317931	51/182 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..432		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..548		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..697		8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159370
Domainoid	1	1.000	95	1.000	Domainoid score	I7420
eggNOG	1	0.900	-	-		E1_28I5W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004975
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16650
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5200
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.830