Protein Alignment CG6652 and LCA5L

DIOPT Version :9

• Sequence 1: NP_648946.3
• Gene: CG6652 / 39905
• FlyBaseID: FBgn0036687
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: XP_011527760.1
• Gene: LCA5L / 150082
• HGNCID: 1255
• Length: 719
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 113/537 - (21%)
• Similarity: 213/537 - (39%)
• Gaps: 130/537 - (24%)

  Fly    67 MSSQNHSEIHQRVMSARNLRAKTFQNQLADAQAEIANLAHENRMLRTLHNRQSSALNKYEAHNAE 131
            |.:|....:..|::|||..:.|..:|:|||...::..:..||:.|:.|..|...|:.|||.....
Human   180 MIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNN 244

  Fly   132 LPKLLSSHAEELRMWQTKYRKLQAANKALELKLKQKEEIILTLSDQNKHYSQLNKDKNLDERQKL 196
            ||::::.|..|::..:...||.|...:.|..||::.:..:|...|..:...:|::||||.||::|
Human   245 LPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREEL 309

  Fly   197 QEKLKSLEQRLEEKDNDMKLMARKVQLESKNIRQQLLNEQRKGKEVMLKLEKAKLEISGYRKLEE 261
            ..||..:..:::..|..::.:.::::|..:...:||..|.||
Human   310 THKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRK----------------------- 351

  Fly   262 YTLGTDKVNPLSSGRRTKLSGVTDEPDKIDKLEKSMEMLDKAIEKNNQSEFTALTDVMESESFYD 326
                     .|::...||...|     ::..|::.::..|:.:|..|......|.::.::|   |
Human   352 ---------TLAAQTATKTLQV-----EVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTE---D 399

  Fly   327 FEKDSAEDKSGPNTPPSQIERQVGGRGGKLILPPATNHAKMGQKANRSTLSQVLSAQGKISVSSG 391
            :.|.|       :|...|.:|:        |||..:...:..||::...|:           :.|
Human   400 YPKVS-------STKSVQADRK--------ILPFTSMRHQGTQKSDVPPLT-----------TKG 438

  Fly   392 KSAKSRIAVAVPKMESVQVSKRREPETVSRLASAETKPKQKPLEYEYEDDYEPAGEDGDDDAYGM 456
            |.|...|.   .|.:|.::: ...|..|::|      |||:..:.:|||
Human   439 KKATGNID---HKEKSTEIN-HEIPHCVNKL------PKQEDSKRKYED---------------- 477

  Fly   457 MSKMCEGEEPQDNSEENANESSLLKYSAYMDNKSSEGDPLEESMEEYDGTDGQQ----------- 510
                ..|||..            |:....::|...:.|..|:..::......:|
Human   478 ----LSGEEKH------------LEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIH 526

  Fly   511 -SQGSDDEDISVRAPRLKENMSSLRKQISNDF-KERESFLKTFCRQASNSNMRDDSASKKRNSIA 573
             .:.|:.||:.|| .:.|.:|.  |..:.:.. |....:.|...||..:.:..:.:.:......|
Human   527 PERESNQEDVLVR-EKFKRSMQ--RNGVDDTLGKGTAPYTKGPLRQRRHYSFTEATENLHHGLPA 588

  Fly   574 TGAAAS------SHMTG 584
            :|..|:      ||.||
Human   589 SGGPANAGNMRYSHSTG 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6652	NP_648946.3	Lebercilin	82..257	CDD:292252	45/174 (26%)
		GBP_C	<151..252	CDD:303769	25/100 (25%)
		coiled coil	239..250	CDD:293879	0/10 (0%)
LCA5L	XP_011527760.1	Lebercilin	195..374	CDD:292252	50/215 (23%)
		BAR	<206..>299	CDD:299863	25/92 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159371
Domainoid	1	1.000	95	1.000	Domainoid score	I7420
eggNOG	1	0.900	-	-		E1_28I5W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004975
OrthoInspector	1	1.000	-	-		oto89145
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16650
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.890