DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6652 and LOC100497171

DIOPT Version :9

Sequence 1:	NP_648946.3	Gene:	CG6652 / 39905	FlyBaseID:	FBgn0036687	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_002937268.2	Gene:	LOC100497171 / 100497171	-ID:	-	Length:	678	Species:	Xenopus tropicalis

Alignment Length:	709	Identity:	157/709 - (22%)
Similarity:	280/709 - (39%)	Gaps:	161/709 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RKLASSYGPRVSQSEPN----------NLMAASAKSCESLFSASS---------RESASLIYQRS 50
            |.....|..|.|..:.|          |....|.:| .|..|.||         |.|..|..|.|
Frog    11 RNKREDYQDRSSDGDKNSDSYYSDDYENTTYRSDRS-PSFMSRSSQAKKLGHKMRSSTPLHNQAS 74

  Fly    51 KPPP---PQQRGGVK-GSGSMSSQNHSE------IHQRVMSARNLRAKTFQNQLADAQAEIANLA 105
            ....   |.::||.| |..|.|....|.      :.:||:|||.|:....:|::.:.|.::....
Frog    75 NKVGSKFPSRKGGAKWGFRSQSLNKESPPKDIALVTKRVLSARLLKINELRNEIRELQIKLEQHQ 139

  Fly   106 HENRMLRTLHNRQSSALNKYEAHNAELPKLLSSHAEELRMWQTKYRKLQAANKALELKLKQKEEI 170
            .||::|:.|..||..|||::|...:|:.:|:|.|..|.|..:...||.|...:..|.:||:.|:.
Frog   140 KENKILKKLQFRQEKALNRFEDTESEISQLISRHNNETRALKEHLRKSQERERNTEKRLKEAEDE 204

  Fly   171 ILTLSDQNKHYSQLNKDKNLDERQKLQEKLKSLEQRLEEKDNDMKLMARKVQLESKNIRQQLL-- 233
            :...:...|...||:::::|.||::|.:||...|.:|:|::..::.:.:|:::...:.::||:
Frog   205 LYRANSTVKKLKQLSENQHLGEREELAKKLDITETKLDEQERRVQDLEKKLEITQNSFQRQLMVE 269

  Fly   234 -----NEQRKGKEVMLKLEKA--KLE----------ISGYRKLEEYTLGTDKVNP--------LS 273
                 |.|.:.|.::.:|:|.  ||:          |..||..:.......::||        :|
Frog   270 KKKIQNAQEENKMLLEELQKLTYKLKEKERELDVKNIYAYRLSKPSPKKDAEINPRWKEARNTIS 334

  Fly   274 SGRRT-------KLSGVTDEPDKI---DKLEKSMEML---DKAIEKNNQSEFTALTDVMESESFY 325
            :|.:|       ::|.::.....|   |..||..|:|   .|..||..:.|...|....|.|.
Frog   335 TGVQTTAHISLVEISSLSHPTPAIPGEDVKEKQHELLQMKQKDYEKQLREEAEKLRKHKELEE-- 397

  Fly   326 DFEKDSAEDKSGPNTPPSQIERQVGGRGGKLILPPATNHAKMGQKANRSTLSQVLSAQ------G 384
              .|...|.|.     ..|.|:::.....|          ||.::..:..|.:.....      |
Frog   398 --RKREEEQKQ-----QRQEEQRILEEKAK----------KMREEWEKEELERKRRENFYQDKIG 445

  Fly   385 KISVSSGKSAKSRIAVAVPKMESVQVSKRRE---------PETVSRLASAETKPKQKPLEYEYED 440
            |.::...:..:.:..:.:.||.  ::.|..|         ..|.:.|:.:..|.:.|..:::...
Frog   446 KQNIQGAEDERLKKELLLAKMN--EIDKESENTMHFDSLKSHTQTLLSDSSLKHETKETKHKIYK 508

  Fly   441 DYEPAGE-------DGDDDAYGMMSKMCEGEEPQDNSEENANESSLLKYSAYMDN--KSSEGDPL 496
            ..||...       .|..:|      .....||:..:|:..|..:.:.:.:|..:  |:..|.|:
Frog   509 FTEPTQNLFSGIPVQGGREA------SLAANEPKVTNEKRFNNVNDVSFGSYAPSFAKTRSGGPV 567

  Fly   497 --EESMEEYD---------GTDG-----QQSQGSDDEDISVRAPRLKENMSSLRKQISNDF---- 541
              .|.:||.|         .||.     :|..|:|.     .||...::..|:.|..|...
Frog   568 LKTEILEEPDIINHSKFNMHTDKKSNLMEQLFGNDS-----NAPVRPKSSDSIAKNESKSIFPLE 627

  Fly   542 KERESFLKTFCRQASNSNMRDDSASKKRNSIATGAAASSHMTGSRKNALLAALKTIDDN 600
            |..:..:|.:.......|::    ..:.|        |.:|||   |..:.||.:::|:
Frog   628 KGGDVKIKNYFFSGDGKNVK----PTRHN--------SQYMTG---NQSVKALDSLEDD 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6652	NP_648946.3	Lebercilin	82..257	CDD:292252	51/193 (26%)
		GBP_C	<151..252	CDD:303769	28/109 (26%)
		coiled coil	239..250	CDD:293879	3/12 (25%)
LOC100497171	XP_002937268.2	Lebercilin	116..301	CDD:406132	50/184 (27%)
LOC100497171	XP_002937268.2	Smc	<146..466	CDD:224117	75/338 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004975
OrthoInspector	1	1.000	-	-		otm47981
Panther	1	1.100	-	-	O	PTHR16650
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010