DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7728 and BMS1

DIOPT Version :9

Sequence 1:	NP_648945.1	Gene:	CG7728 / 39904	FlyBaseID:	FBgn0036686	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_055568.3	Gene:	BMS1 / 9790	HGNCID:	23505	Length:	1282	Species:	Homo sapiens

Alignment Length:	1309	Identity:	577/1309 - (44%)
Similarity:	790/1309 - (60%)	Gaps:	224/1309 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RKQHRARQSGVKADKKKLKAKKDSNQKEPELTARQRNPKAFAINSAQRAERNFRRKEDLTAKKQH 74
            :|:||.:.||.||.|||.:..:|. |...|..||:|||||||:.||.|..|:|.|.:||..||.|
Human     6 QKKHRKKNSGPKAAKKKKRLLQDL-QLGDEEDARKRNPKAFAVQSAVRMARSFHRTQDLKTKKHH 69

  Fly    75 IPVVDQTPNVPPPVLIAVVGPPKVGKTTLIKDLIKSFTRTNVTDIKGPITIVTSKKRRITLLECN 139
            |||||:||..|||:::.|:|||||||:|||:.||::|||..:|:|:||:|||:.||||:|::||.
Human    70 IPVVDRTPLEPPPIVVVVMGPPKVGKSTLIQCLIRNFTRQKLTEIRGPVTIVSGKKRRLTIIECG 134

  Fly   140 NDVNSMIDVAKCADLVLLLCDASYGFEMEIFEFLNICQVHGMPKIMGVLTHLDMIKNPKQLRKRK 204
            .|:|.|||:||.|||||:|.|||:|||||.|||||||||||.|||||||||||..|:.|||:|.|
Human   135 CDINMMIDLAKVADLVLMLIDASFGFEMETFEFLNICQVHGFPKIMGVLTHLDSFKHNKQLKKTK 199

  Fly   205 KELKHRFWTEVYDGAKLFYLSGLLHGEYLRNEVKNLGRFISVMKFRPLQWRGAHSYLLVDRIEDV 269
            |.||||||||||.|||||||||::||||...|:.||||||:|||||||.|:.:|.|:|.||:||:
Human   200 KRLKHRFWTEVYPGAKLFYLSGMVHGEYQNQEIHNLGRFITVMKFRPLTWQTSHPYILADRMEDL 264

  Fly   270 TNTDRVRRDPKCDREVVLYGYVRGVPLKQEHMVHIAGLGDARIDELNVIPDPCPLPGTEKKRSLL 334
            ||.:.:|.:.||||:|.||||:||..||.:..:|:.|:||..:.:::.:||||.||..:|||.|.
Human   265 TNPEDIRTNIKCDRKVSLYGYLRGAHLKNKSQIHMPGVGDFAVSDISFLPDPCALPEQQKKRCLN 329

  Fly   335 EKERLLYAPMSGVGGIVYDKDAVYIELQGSHSHKEQEQTAEAAEQAELVNKLIDKKATIDEQMEQ 399
            |||:|:|||:|||||::|||||||::|.|||..::     |.....|||..||...:|||.:|..
Human   330 EKEKLVYAPLSGVGGVLYDKDAVYVDLGGSHVFQD-----EVGPTHELVQSLISTHSTIDAKMAS 389

  Fly   400 QEFRLFSDAKPIKSKDFRND---------QDD------------EEEDEEAESSENEDDD-GEDS 442
            ....||||:||:.|:|..|.         |.|            .:|||..:|.:.|||: .||.
Human   390 SRVTLFSDSKPLGSEDIDNQGLMMPKEEKQMDLNTGRMRRKAIFGDEDESGDSDDEEDDEMSEDD 454

  Fly   443 GLDAADSEEEQQDE---------------------------------FDADDWRGENSEEEEDAE 474
            ||:...|:||.::|                                 .|:||....:|.||.:||
Human   455 GLENGSSDEEAEEEENAEMTDQYMAVKGIKRRKLELEEDSEMDLPAFADSDDDLERSSAEEGEAE 519

  Fly   475 EDASSGDEEYQSLG----------------------------NVKTS------------------ 493
            |...|.:||..:.|                            |::.|
Human   520 EADESSEEEDCTAGEKGISGSKAAGEGSKAGLSPANCQSDRVNLEKSLLMKKAALPTFDSGHCTA 584

  Fly   494 ------------------NESDSDDEEA------------------------------------- 503
                              .|.||::|||
Human   585 EEVFASEDESEESSSLSAEEEDSENEEAIRKKLSKPSQVSSGQKLGPQNFIDETSDIENLLKEEE 649

  Fly   504 ---------RVLASNMSWKTNLAQKARDAFLQRHSESKNLMRLVYGVYNQSEHSRQEAEAEDDSE 559
                     :..:..:.||.:|::||.:|||::...:.||.:|:||...:...     |.:||:.
Human   650 DYKEENNDSKETSGALKWKEDLSRKAAEAFLRQQQAAPNLRKLIYGTVTEDNE-----EEDDDTL 709

  Fly   560 EELGGLFRVAAKKQSLKQSDQDIRDK-DERCFFEYQGDATRDWLAEDNKELIKNCFVTGKWKASE 623
            |||||||||       .|.|::.:.| |......:..:|..||..|:....|::|||||||:..:
Human   710 EELGGLFRV-------NQPDRECKHKADSLDCSRFLVEAPHDWDLEEVMNSIRDCFVTGKWEDDK 767

  Fly   624 DAENLLKMDDMSDAESEVYGDFEDLETGEQHSGKPKAEDGGESEEENSKPEDSSAPKRKLTRVEE 688
            ||..:|..|:      |:||||||||||:.|.||    .|..::.|:.:.|    .|.::...||
Human   768 DAAKVLAEDE------ELYGDFEDLETGDVHKGK----SGPNTQNEDIEKE----VKEEIDPDEE 818

  Fly   689 ENLTKAELMAKKLKLKAKFDAEYDNSGEGKGEEDNGRITGDHSFYEDLKAEAQRQSELNKSEFAH 753
            |:..|..| .||.|||..||||||.              |:.::::|||.|.|:|::||::||..
Human   819 ESAKKKHL-DKKRKLKEMFDAEYDE--------------GESTYFDDLKGEMQKQAQLNRAEFED 868

  Fly   754 LDNEFRIQIEGYRPGLYVRLGFKQLPAEFIENFDASYPVLVGALNMTEENVGYVNCKVKKHRWYK 818
            .|:|.|:|.||:|||:|||:..:.:|.||::|||..||:::|.|..:|.|||||..::|||||||
Human   869 QDDEARVQYEGFRPGMYVRIEIENVPCEFVQNFDPHYPIILGGLGNSEGNVGYVQMRLKKHRWYK 933

  Fly   819 KILKTGDPLIISMGWRRFQTVAIYAKVEDNFRQRYLKYTPNHVTCSMTFWGPITPQNTGFLALQT 883
            ||||:.||:|.|:|||||||:.:|...:.|.|||.|||||.|:.|...||||||||.|||||:|:
Human   934 KILKSRDPIIFSVGWRRFQTIPLYYIEDHNGRQRLLKYTPQHMHCGAAFWGPITPQGTGFLAIQS 998

  Fly   884 VRQDQEEMRRLGFRIAATGCVTEVDKSSQIMKKLKLVGHPFKIYKKTAFVKDMFNSSLEVAKFEG 948
            |.....:     |||||||.|.::|||.:|:|||||.|.|:||:|.|:|:|.||||:||||||||
Human   999 VSGIMPD-----FRIAATGVVLDLDKSIKIVKKLKLTGFPYKIFKNTSFIKGMFNSALEVAKFEG 1058

  Fly   949 AKIKTVSGIRGQIKKAHHTPEGSYRATFEDKILLSDIVFCRTWFRVEVPRFYAPVSSLLLPLDQK 1013
            |.|:||||||||||||...|||::||:||||:|:|||||.|||:.|.:|.||.||:|||.|:.:|
Human  1059 AVIRTVSGIRGQIKKALRAPEGAFRASFEDKLLMSDIVFMRTWYPVSIPAFYNPVTSLLKPVGEK 1123

  Fly  1014 SQWQGMKTLGQLKRERAVQNAAQPDSMYTTIVRKEKIFRPLTIPKALQRALPYKDKPKLGPENPK 1078
            ..|.||:|.|||:....|:..|..||:|..|:|::|.|..|.||||||:|||:|:|||...:..|
Human  1124 DTWSGMRTTGQLRLAHGVRLKANKDSLYKPILRQKKHFNSLHIPKALQKALPFKNKPKTQAKAGK 1188

  Fly  1079 AALE--RVAVVNSPYEQKVSKMMKMIET--NFKDKRQRERMEMKKRIKNYREKKREKMASQERRQ 1139
            ...:  |.||:..|:|:|:..::..:.|  :.|.|:.:|:..:..: :::|.|::|: ..:.:||
Human  1189 VPKDRRRPAVIREPHERKILALLDALSTVHSQKMKKAKEQRHLHNK-EHFRAKQKEE-EEKLKRQ 1251

  Fly  1140 KELRKKVSR 1148
            |:||||:.|
Human  1252 KDLRKKLFR 1260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7728	NP_648945.1	BMS1	34..1140	CDD:227519	559/1275 (44%)
		BMS1	49..279	CDD:206669	152/229 (66%)
		RIBIOP_C	707..994	CDD:282764	163/286 (57%)
BMS1	NP_055568.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		17/37 (46%)
		BMS1	41..1271	CDD:227519	561/1273 (44%)
		BMS1	44..273	CDD:206669	152/228 (67%)
		G1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01051	89..96		6/6 (100%)
		G2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01051	117..121		2/3 (67%)
		G3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01051	132..135		2/2 (100%)
		G4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01051	184..187		2/2 (100%)
		G5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01051	219..228		6/8 (75%)
		AARP2CN	231..317	CDD:129021	44/85 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..557		36/159 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..667		6/91 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	787..822		13/42 (31%)
		RIBIOP_C	834..1104	CDD:282764	163/288 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1178..1202		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1219..1282		14/44 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149939
Domainoid	1	1.000	354	1.000	Domainoid score	I1006
eggNOG	1	0.900	-	-		E1_COG5192
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7065
Inparanoid	1	1.050	957	1.000	Inparanoid score	I333
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53908
OrthoDB	1	1.010	-	-		D124520at33208
OrthoFinder	1	1.000	-	-		FOG0005253
OrthoInspector	1	1.000	-	-		oto89276
orthoMCL	1	0.900	-	-		OOG6_102112
Panther	1	1.100	-	-	LDO	PTHR12858
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R142
SonicParanoid	1	1.000	-	-		X3775
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800