DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7728 and Y61A9LA.10

DIOPT Version :9

Sequence 1:	NP_648945.1	Gene:	CG7728 / 39904	FlyBaseID:	FBgn0036686	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_504245.3	Gene:	Y61A9LA.10 / 178851	WormBaseID:	WBGene00022021	Length:	1055	Species:	Caenorhabditis elegans

Alignment Length:	1165	Identity:	498/1165 - (42%)
Similarity:	704/1165 - (60%)	Gaps:	153/1165 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GQDKRKQHRARQSGVKADKKKLKAKKDSNQKEPELTARQRNPKAFAINSAQRAERNFRRKEDLTA 70
            || |.|.|...::|.||.|:        |:|||.:  :..|.|||..:||..|.:..||..||..
Worm     9 GQ-KNKGHNVHKTGGKAKKR--------NEKEPRV--KGNNLKAFTFHSAVSAGKAIRRAADLNE 62

  Fly    71 KKQHIPVVDQTPNVPPPVLIAVVGPPKVGKTTLIKDLIKSFTRTNVTDIKGPITIVTSKKRRITL 135
            ||:|:.::|:.|...||:::|:|||.|||||||::.|:|.:.|....:|.||:||||.||||:..
Worm    63 KKKHVLMMDRKPIETPPIIVAIVGPSKVGKTTLLRGLVKYYLRDGFGEINGPVTIVTGKKRRVQF 127

  Fly   136 LECNNDVNSMIDVAKCADLVLLLCDASYGFEMEIFEFLNICQVHGMPKIMGVLTHLDMIKNPKQL 200
            :|..||:|.|||:||.||||||:.|||||||||.|||||||||||||:|||||.|||::....::
Worm   128 IEVKNDINHMIDIAKVADLVLLMVDASYGFEMETFEFLNICQVHGMPRIMGVLNHLDLLDGISRV 192

  Fly   201 RKRKKELKHRFWTEVYDGAKLFYLSGLLHGEYLRNEVKNLGRFISVMKFRPLQWRGAHSYLLVDR 265
            .|.||.||||||||:|.||||||::|::||:|..||:.||.||||||||||:.|:.||.|:|.||
Worm   193 NKTKKILKHRFWTELYQGAKLFYMTGMMHGQYKYNEIHNLCRFISVMKFRPMVWKDAHPYVLCDR 257

  Fly   266 IEDVTNTDRVRRDPKCDREVVLYGYVRGVPLKQEHMVHIAGLGDARIDELNVIPDPCPLPGTEKK 330
            .||:||.:.:|.||..||.:.:||:|.|..||....:|:.|:||.||..:..:|||||||...||
Worm   258 FEDITNVETLRTDPLIDRHIAMYGWVHGAHLKNHSSIHVPGVGDMRISNVTSLPDPCPLPDEIKK 322

  Fly   331 RSLLEKERLLYAPMSGVGGIVYDKDAVYIELQGSHS-HKEQEQTAEAAEQAELVNKLIDKKATID 394
            |:|.||||.:|||.||:||::|||||:|||.:.:|: :::::...||.|..         |:.||
Worm   323 RALNEKERKVYAPFSGLGGVIYDKDAIYIESKNAHNFNRKRDGLVEALEGV---------KSGID 378

  Fly   395 EQMEQQEFRLFSDAKPIKSKDFRNDQDDEEEDEEAESSENEDDDGEDSGLDAADSEEEQQDEFDA 459
            :::::...:|..|:..:            :.|:|::..|..::|.||  ||..|.::|::||
Worm   379 DKLKKSSLQLLGDSVAL------------DIDQESDWPEPGEEDEED--LDEEDFQDEEEDE--- 426

  Fly   460 DDWRGENSEEEEDAEEDASSGDEEYQSLGNVKTSNESDSDDEEARVLASNMSWKTNLAQKARDAF 524
                    :|:|| |||          :|.||  .|.|.::           | :|||.||...:
Worm   427 --------DEDED-EED----------VGVVK--KEEDQNE-----------W-SNLASKAVAQY 458

  Fly   525 LQRHSESKNLMRLVYGVYNQSEHSRQEAEAEDDSEEELGGLFRVAAKKQSLKQSDQDIRDKDERC 589
            .:..:...|.|:||||         .|...:|:.||.:..||.|  :||:.|..|      |:..
Worm   459 RESQNVKVNWMKLVYG---------GEKVTKDEKEETIDDLFVV--RKQNQKSED------DQED 506

  Fly   590 FFEYQ------GDATRDWLAEDNKELIKNCFVTGKWKASEDAENLLKMDDMSDAESEVYGDFEDL 648
            .|.|.      ..:|.||..|:.::.|.:.||||.|...:..|:.||.:..||.|..  .|.||:
Worm   507 GFGYAMLPASCSTSTNDWDLEEVRKSIADSFVTGNWTEDDAEEDQLKKEIGSDNEDN--DDGEDM 569

  Fly   649 ETGEQHSGKPKAEDGGESEE-ENSKPEDSSAPK-RKLTRVEEENLTKAELMAKKLKLKAKFDAEY 711
            :..|        |||.:.|. .|.|.|:|.|.| ||..|:|           .|:|||.:|:.:|
Worm   570 DDEE--------EDGDDDETGGNEKKEESEADKSRKQKRLE-----------AKIKLKQRFNDDY 615

  Fly   712 DNSGEGKGEEDNGRITGDHSFYEDLKAEAQRQSELNKSEFAHLDNEFRIQIEGYRPGLYVRLGFK 776
            |.:.:               ||...|.|...|::||:..|..:|.|.|.::||:|.|.|||:...
Worm   616 DETCK---------------FYNKAKNEMTEQADLNRQVFEGMDEEEREKVEGFRSGRYVRIEIS 665

  Fly   777 QLPAEFIENFDASYPVLVGALNMTEENVGYVNCKVKKHRWYKKILKTGDPLIISMGWRRFQTVAI 841
            .:|.||:::||.|.|.::|.|...|:|:|.|..:||:|||:::.||:.||||||.|||||||:||
Worm   666 SVPCEFVDHFDTSAPYIIGGLLPGEQNMGVVQARVKRHRWFERTLKSRDPLIISCGWRRFQTIAI 730

  Fly   842 YAKVEDNFRQRYLKYTPNHVTCSMTFWGPITPQNTGFLALQTVRQDQEEMRRLGFRIAATGCVTE 906
            |:..:.|.|.|:|||||.|:.|..:|:||:..||||.||:|::..     :..|:||.|||.|.:
Worm   731 YSVQDHNMRLRFLKYTPEHMHCHASFFGPVCAQNTGLLAIQSIAD-----KTPGYRIVATGGVLD 790

  Fly   907 VDKSSQIMKKLKLVGHPFKIYKKTAFVKDMFNSSLEVAKFEGAKIKTVSGIRGQIKKAHHTPEGS 971
            :|||:|::|||||:|||.||:|||||||.||||:|||||||||.|:||:|||||||||...|||:
Worm   791 LDKSTQVVKKLKLIGHPEKIFKKTAFVKGMFNSALEVAKFEGATIRTVAGIRGQIKKAIKAPEGA 855

  Fly   972 YRATFEDKILLSDIVFCRTWFRVEVPRFYAPVSSLLLPLDQKSQWQGMKTLGQLKRERAVQNAAQ 1036
            :|||||||||:.||||.|:|..|.:||||.|:|..|..  ..:.|.||:|:|:::.|..:.....
Worm   856 FRATFEDKILMRDIVFLRSWVTVPIPRFYTPISDHLQA--SAAAWIGMRTVGKMRSELGMGTPQN 918

  Fly  1037 PDSMYTTIVRKEKIFRPLTIPKALQRALPYKDKP--KLGPENPKAAL--ERVAVVNSPYEQKVSK 1097
            .||.|..|||||....|:.:|..||::||:|.||  :...|..|.:|  ...|||..|.|.|..:
Worm   919 KDSDYKPIVRKEFESAPIHLPPKLQKSLPFKMKPTYQAREEKEKDSLVARHTAVVLEPEEAKRER 983

  Fly  1098 MMKMIET-NFKDKRQRERMEMKKRIKNYREKKREKMA-SQERRQKEL---RKKVSRAISK 1152
            .|.|:.| |..|.:::|.::     :.|:::|.|:|| |:.:|:|.:   :|.:||.:||
Worm   984 FMDMLRTLNDVDLKKQENIK-----EGYKKRKAEEMAESEAKREKSIKSRKKDISRVLSK 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7728	NP_648945.1	BMS1	34..1140	CDD:227519	483/1120 (43%)
		BMS1	49..279	CDD:206669	134/229 (59%)
		RIBIOP_C	707..994	CDD:282764	148/286 (52%)
Y61A9LA.10	NP_504245.3	BMS1	10..1045	CDD:227519	497/1164 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161278
Domainoid	1	1.000	313	1.000	Domainoid score	I707
eggNOG	1	0.900	-	-		E1_COG5192
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7065
Inparanoid	1	1.050	856	1.000	Inparanoid score	I219
Isobase	1	0.950	-	0	Normalized mean entropy	S2249
OMA	1	1.010	-	-		QHG53908
OrthoDB	1	1.010	-	-		D124520at33208
OrthoFinder	1	1.000	-	-		FOG0005253
OrthoInspector	1	1.000	-	-		oto18992
orthoMCL	1	0.900	-	-		OOG6_102112
Panther	1	1.100	-	-	LDO	PTHR12858
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R142
SonicParanoid	1	1.000	-	-		X3775
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750