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Protein Alignment CG3764 and FNIP1

DIOPT Version :10

Sequence 1:	NP_001261977.1	Gene:	CG3764 / 39902	FlyBaseID:	FBgn0036684	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	NP_588613.3	Gene:	FNIP1 / 96459	HGNCID:	29418	Length:	1166	Species:	Homo sapiens

Alignment Length:	1462	Identity:	327/1462 - (22%)
Similarity:	533/1462 - (36%)	Gaps:	431/1462 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 FEGSQVRVLLYKEDDT--RRLLFDSNALQKVMHKDQSATSASISSTSTSGGGKFLKNEKYTSLQN 159
            |:.||:|:::|::.:.  |.:||||:..::         :..||.:......:.....|...|:.
Human    37 FDPSQIRLIVYQDCERRGRNVLFDSSVKRR---------NEDISVSKLGSDAQVKVFGKCCQLKP 92

  Fly   160 GKIPSKSHSS---NGSNFIEVCAEYGYKHNRPSGADITPVGEMVFGSLPMSFCGTALKVHWLPEP 221
            |...|.|..|   :.|:..:.|.:  |:.:|.| :|...:|||:|||:.||:.|:.||:|.:..|
Human    93 GGDSSSSLDSSVTSSSDIKDQCLK--YQGSRCS-SDANMLGEMMFGSVAMSYKGSTLKIHQIRSP 154

  Fly   222 SRILCSQVYLTPTSNG--GSGHSPYSTL-----STNSLATPRTSICSEHGSMDGLSMNSFSMPFS 279
            .:::.|:|:...|.:.  ||.::...:|     ..|:|.....::.  :|.:..:.::.|..|
Human   155 PQLMLSKVFTARTGSSICGSLNTLQDSLEFINQDNNTLKADNNTVI--NGLLGNIGLSQFCSP-- 215

  Fly   280 VSVGRQMSLTPPL---------DVPATPADQQSLSIHSIDSSGPRYSSTYSTATDSGYSASGSGS 335
               .|..|...||         .|.:.|.|.....::....||...|::.|:...:.:.:..|
Human   216 ---RRAFSEQGPLRLIRSASFFAVHSNPMDMPGRELNEDRDSGIARSASLSSLLITPFPSPNS-- 275

  Fly   336 AAGGDQWSYQYSSTRSSLGSVLSDQSDAMRKLSMDLACYTGSPYLDGFASDGCLQRRISRNLRTS 400
                       |.|||...|                                 .|||..|:..||
Human   276 -----------SLTRSCASS---------------------------------YQRRWRRSQTTS 296

  Fly   401 FENEHSKNDFIGFLSDNYALNGPVVAPAGGGAGGGSEGGGMAPPQYRRASYCANETRSNPEMGRR 465
            .||                                    |:.|......|:..::....|..|
Human   297 LEN------------------------------------GVFPRWSIEESFNLSDESCGPNPG-- 323

  Fly   466 QANLRRRAKLGLAVCISMSESFEEEMEL--FCSEHIALLESMLSRLRASTE-------------- 514
               :.|:.|:.:.|..|:|:..:|..:.  |...|..|.||.:::|:::.|
Human   324 ---IVRKKKIAIGVIFSLSKDEDENNKFNEFFFSHFPLFESHMNKLKSAIEQAMKMSRRSADASQ 385

  Fly   515 --LAYINHKNFLQIMFQAWQDTQQWFSDLFTAPRIKTPVWLSITTSGSKYSKTVAERFIKELCDL 577
              |||       ..:..|..:.:....:|:|.|||..||||:: .||:.....:..||:||...|
Human   386 RSLAY-------NRIVDALNEFRTTICNLYTMPRIGEPVWLTM-MSGTPEKNHLCYRFMKEFTFL 442

  Fly   578 LSFADTKDSNFFISTMLTGILTHHLGWVATVSAFNSSGSKRSESSASAAAIEQRAKLLQVAQKHP 642
            :   :....|.|:..::|.:||:||.||.||........|......|:.:::..||      .||
Human   443 M---ENASKNQFLPALITAVLTNHLAWVPTVMPNGQPPIKIFLEKHSSQSVDMLAK------THP 498

  Fly   643 YNALWAQLGDLYGAIGMPPKLARTIVCGAEKLWVEKLLNVLTYFIRCSEVRRAAKREDFNKQLIN 707
            ||.|||||||||||||.|.:||||:|.|..:..|::||..|||||||||::.....|:...:.|.
Human   499 YNPLWAQLGDLYGAIGSPVRLARTVVVGKRQDMVQRLLYFLTYFIRCSELQETHLLENGEDEAIV 563

  Fly   708 DLAAQSQTKNQTG----------TQERHKSPPTQKRGLS-RAATCKQNLNAIADDADDENGELNM 761
            .......|..:.|          |..|:||....|.... |...|  |....:.....:|.| |:
Human   564 MPGTVITTTLEKGEIEESEYVLVTMHRNKSSLLFKESEEIRTPNC--NCKYCSHPLLGQNVE-NI 625

  Fly   762 YDRDNEDGDPDGLDSGS---LDASDGMQTLKKNEIPTVLAFRDSHFVQQELRIGNYLMDTGIDKK 823
            ..::.||     :.:.|   |..||..|.:..::.             ||        :..:|.|
Human   626 SQQERED-----IQNSSKELLGISDECQMISPSDC-------------QE--------ENAVDVK 664

  Fly   824 MLLARQAQQYFRTGKDGRIRLTVTTPDNVELCMEEEQSSGTGSVSTGSVDDGAIEAIDYEDNVEA 888
                 |.:...||..|.::...|        |        ||||   .||..|:.....|...|.
Human   665 -----QYRDKLRTCFDAKLETVV--------C--------TGSV---PVDKCALSESGLESTEET 705

  Fly   889 PPKKNFFWNMVPVAGVKEGLSLSDLAKLQQGIRIINRKLERRSSSYSVEGNPDQQQSKTGETGVG 953
                   |.       .|.|..||          .:.....||:...||..|..:
Human   706 -------WQ-------SEKLLDSD----------SHTGKAMRSTGMVVEKKPPDK---------- 736

  Fly   954 DFEPLSHERRASHLSLSDLITQNSMGKSDRMTWGIEPIKENVSLEEQIHFD----HCHKLIEREH 1014
             ..|.|....|:...::.||..:....||            ..|..|...|    |..|.::.|.
Human   737 -IVPASFSCEAAQTKVTFLIGDSMSPDSD------------TELRSQAVVDQITRHHTKPLKEER 788

  Fly  1015 GICRQTSADNGNGVVFVLGDNEPLINLKKSSEDLSGDQDS------KPTLMLCAQHQRTHDRSKH 1073
            |...|..                  ..|::::|.||:.|:      :|..:.|..|......|.
Human   789 GAIDQHQ------------------ETKQTTKDQSGESDTQNMVSEEPCELPCWNHSDPESMSL- 834

  Fly  1074 SGMKFNFEQYPQIATNYMKNKNLLMSNYDLLMDKVTKLEASEAAALKGSDSTATLAASSSSTAAL 1138
                  |::|               .|.|                   |..|.|:......|:
Human   835 ------FDEY---------------FNDD-------------------SIETRTIDDVPFKTS-- 857

  Fly  1139 LPPTTPVTANSDRCVVCSSGVGINTSATWNQTPSNATELEFETDEMHCYNQSGNGNGFSSKALQS 1203
                   |.:.|.|.:                      |||  .::.|...:...|.| .|.:::
Human   858 -------TDSKDHCCM----------------------LEF--SKILCTKNNKQNNEF-CKCIET 890

  Fly  1204 VNSAASIDTLKSSVAVEPPTPTIPTQMQTTYM--------RKQQPKR--------VPSGRSSVSS 1252
            |..    |:.|:         ..|.|.|...:        ::...|:        :|...||.|:
Human   891 VPQ----DSCKT---------CFPQQDQRDTLSILVPHGDKESSDKKIAVGTEWDIPRNESSDSA 942

  Fly  1253 VA---AKCAAVNVSQQLL--------------KLPVPGIKELPQDDESPGDQLRAGFIPSLLLSV 1300
            :.   ::....::::|:.              ::|.||.|.:......|.   .|.|..|||...
Human   943 LGDSESEDTGHDMTRQVSSYYGGEQEDWAEEDEIPFPGSKLIEVSAVQPN---IANFGRSLLGGY 1004

  Fly  1301 SDHYVSDMVLQGTCAPPNKWEMHLREDLALAARSASLISQPAENIAIVADMDKWDVRLISSQTQQ 1365
            ...||.|.|||| .....::...|..||:.|.:...|....||.:.|:||||||.|::.|||.:.
Human  1005 CSSYVPDFVLQG-IGSDERFRQCLMSDLSHAVQHPVLDEPIAEAVCIIADMDKWTVQVASSQRRV 1068

  Fly  1366 FPYAGGQSSPVGMSQLVSSMLETVQAMNAGGIPAYECLSFLESKLQEIYLQSETLAAFLLETDPC 1430
            .....|:.  |.:|.|||::|.:...:....:....|:..||.:|||:|.:|:.|:.:|......
Human  1069 TDNKLGKE--VLVSSLVSNLLHSTLQLYKHNLSPNFCVMHLEDRLQELYFKSKMLSEYLRGQMRV 1131

  Fly  1431 RLSDITNPLQLSENDVPLLLSIAYIHTPKISR 1462
            .:.::...|.:..:|:|||.::|..|:|.:::
Human  1132 HVKELGVVLGIESSDLPLLAAVASTHSPYVAQ 1163

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.