Protein Alignment CG3764 and Fnip2

DIOPT Version :10

• Sequence 1: NP_001261977.1
• Gene: CG3764 / 39902
• FlyBaseID: FBgn0036684
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: NP_001392095.1
• Gene: Fnip2 / 329679
• MGIID: 2683054
• Length: 1165
• Species: Mus musculus
• Alignment Length: 1576
• Identity: 349/1576 - (22%)
• Similarity: 566/1576 - (35%)
• Gaps: 571/1576 - (36%)

  Fly    39 SQTTTATTGTATSATTTTLPARTAHASAGVAATASAGNSSSSAKATKQTSRNYL----SRFPFEG 99
            :.:|....|...||...|   .|...:..:..|.........|:..:.|:...|    |...|..
Mouse     6 ADSTNWPVGQQESARCLT---DTTCGAGRIFKTLVCAKIPKCARGGRDTNSTVLNHSWSCSEFGL 67

  Fly   100 SQVRVLLYKEDDT--RRLLFDSNALQKVMH------------------KDQSATSASISSTSTSG 144
            |.:|:|:|::.:.  |:::|||.|:||:..                  ::.|::|.|.||.|:|.
Mouse    68 SDIRLLVYQDCERRGRQVMFDSRAVQKMEEAAAQKAEDVPIKMSARCCQESSSSSGSSSSGSSSS 132

  Fly   145 ---GGKFLKNEKYTSLQNGK--IPSKSHSSNGSNFIEVCAEYGYKHNRPSGADITPVGEMVFGSL 204
               ||         |||:.|  :|.                  |::.||: :|::.:|||:|||:
Mouse   133 HGFGG---------SLQHAKQQLPK------------------YQYTRPA-SDVSMLGEMMFGSV 169

  Fly   205 PMSFCGTALKVHWLPEPSRILCSQVYLTPTSNGGSGHSPYSTLSTNSLATPRTSICSEHGSMDGL 269
            .||:.|:.||:|::..|.:::.|:|: :.|.....|       |||:|......| ::......|
Mouse   170 AMSYKGSTLKIHYIRSPPQLMISKVF-SATMGSFCG-------STNNLQDSFEYI-NQDPQAGKL 225

  Fly   270 SMNSFSM-PF------------------SVSVGRQMSLT----------PPLDVPATPADQQSLS 305
            :.|.::: ||                  .:|.|..:.||          .|:|:|:...::.
Mouse   226 NTNQYNLGPFRTGSNLGLLQVCSGKLLQGLSEGGPLRLTRSASFFAAHSTPVDMPSRGQNED--- 287

  Fly   306 IHSIDSSGPRYSSTYSTATDSGYSASGSGSAAGGDQWSYQYSSTRSSLGSVLSDQSDAMRKLSMD 370
                              .|||.:.|.|.|:.....:....|||.||
Mouse   288 ------------------RDSGIARSASLSSLLITPFPSPSSSTSSS------------------ 316

  Fly   371 LACYTGSPYLDGFASDGCLQRRISRNLRTSFENEHSKNDFIGFLSDNYALNGPVVAPAGGGAGGG 435
                  |.|          |||..|:..||.||
Mouse   317 ------SSY----------QRRWLRSQTTSLEN-------------------------------- 333

  Fly   436 SEGGGMAPPQYRRAS----YCANET-RSNPEMGRRQANLRRRAKLGLAVCISM--SESFEEEMEL 493
                |:.|   ||::    ..|.|| .|||.|.||:       |:.:::..|:  .|:.:.:.:.
Mouse   334 ----GIFP---RRSTDETFSLAEETCSSNPAMVRRK-------KIAISIIFSLCEREAAQRDFQD 384

  Fly   494 FCSEHIALLESMLSRLRASTELAYIN----HKNFLQIMF------QAWQDTQQWFSDLFTAPRIK 548
            |...|..|.||.::||:.:.|.|.|:    .::.|::.|      :|..:.:....:|::.|||.
Mouse   385 FFFSHFPLFESHMNRLKGAIEKAMISCRKISESSLRVQFYVSRLMEALGEFRGTIWNLYSVPRIA 449

  Fly   549 TPVWLSITTSGSKYSKTVAERFIKELCDLLSFADTKDSNFFISTMLTGILTHHLGWVATV----- 608
            .||||:: .|.:.....:.:||:||...|:   :..:.|.|.:.:||.:||:||.||.||
Mouse   450 EPVWLTM-MSNTLEKNQLCQRFLKEFILLI---EQVNKNQFFAALLTAVLTYHLAWVPTVMPVDH 510

  Fly   609 ---SAFNSSGSKRSESSASAAAIEQRAKLLQVAQKHPYNALWAQLGDLYGAIGMPPKLARTIVCG 670
               .||:   .||:..|.:           .:|:.||||.|||||||||||||.|.:|.||:|.|
Mouse   511 PPIKAFS---EKRTSQSVN-----------MLAKTHPYNPLWAQLGDLYGAIGSPVRLTRTVVIG 561

  Fly   671 AEKLWVEKLLNVLTYFIRCSEVRR------AAKREDFNKQLINDL----------AAQSQTKNQT 719
            .:|..|:::|.|||||:||||::.      ....||  .|:||..          ..:|:....|
Mouse   562 KQKDLVQRILYVLTYFLRCSELQENQLSWSGNPSED--DQVINGSKIITALEKGEVEESEYVVVT 624

  Fly   720 GTQERHKSPPTQKRGLSRAATCKQNLNAIADDADDEN-GELNMYDRDNEDGDPDGLDSGSLDASD 783
            .:.|....||...:|.:...:.:..:  :|:.::..| .||......|....|   :..|..:|.
Mouse   625 VSSEPALVPPILPQGTAERRSPEPTV--VAEISEGVNTSELGHKPEKNRCKRP---EQNSEASSM 684

  Fly   784 GMQTLKKNEIPTVLAFRDSHFVQQELRIGNYLMDTGIDKK---------------MLLARQAQQY 833
            |.|.          |..||.::.|    |.:..|...|::               .:..|..||.
Mouse   685 GFQE----------AEPDSSWIPQ----GIFCEDKQNDQEATQDCSSSPPSCEVPRVRRRMDQQT 735

  Fly   834 FRTGKDGRIRLTVTTPDNVELCMEEEQSSGTGSVSTGSVDDGAIEAIDYEDNVEAPPKKNFFWNM 898
            ..:...|.           .|....|||:........|.:|..:|.:.:.......|:.:|
Mouse   736 LHSKLHGE-----------TLKKRAEQSAAWPCPDRHSQEDPPVEKVTFHIGSSISPESDF---- 785

  Fly   899 VPVAGVKEGLSLSDLAKLQQGIRIINRKLERR------------SSSYSVEGNPDQQQSKTGETG 951
                                  ....:::|.|            |:|.|::....|:|..:|.:.
Mouse   786 ----------------------ESRTKRMEERLKACGHFHGASASASSSMDTGLTQEQQGSGCSF 828

  Fly   952 VGDFEPLSHERRASHLSLSDLITQNSMGKSDRMTWGIEPIKENVSLEEQIHFDHCHKLIEREHGI 1016
            ..|||             .|:..|:...       |.|.:.|:..|...:           .|.:
Mouse   829 KADFE-------------KDITPQDHSS-------GGEGVSEDRGLRANM-----------THAV 862

  Fly  1017 CRQTSADNGNGVVFVLGDNEPLINLKKSSEDLSGDQDSKPTLMLCAQHQRTHDRSKHSGMKFNFE 1081
            .:.:..|.            ||.:                  .|||         ..||.:.
Mouse   863 GQLSQVDG------------PLAH------------------SLCA---------AESGRRL--- 885

  Fly  1082 QYPQIATNYMKNKNLLMSNYDLLMDKVTKLEASEAAALKGSDSTATLAASSSSTAALLPPTTPVT 1146
                                         ||.:....|||...               |.:.||
Mouse   886 -----------------------------LEQTRDVQLKGYKG---------------PSSEPV- 905

  Fly  1147 ANSDRCVVCSSGVGINTSATWNQTPSNATELEFETDEMHCYNQSGNGNGFSSKAL---QSVNSAA 1208
              .:||.. ..|:.|.....:.                   :.||.||..|...:   :|::||.
Mouse   906 --PNRCRQ-QGGLLIAADVPYG-------------------DASGKGNYRSEGDIPRNESLDSAL 948

  Fly  1209 -----------------SIDTLKSSVAVEPPTPTIPTQMQTTYMRKQQPKRVPSGRSSVSSVAAK 1256
                             |.|..:.|:.||.|.|                      ||..:|.|
Mouse   949 GDSDDEACVLALLELGHSCDRTEESLEVELPLP----------------------RSQSTSKA-- 989

  Fly  1257 CAAVNVSQQLLKLPVPGIKELPQDDESPGDQLRAGFIPSLLLSVSDHYVSDMVLQGTCAPPNKWE 1321
                ||                   .:.|..|.||:..:        |:.|:||.|| :...|.:
Mouse   990 ----NV-------------------RNFGRSLLAGYCAT--------YMPDLVLHGT-SSDEKLK 1022

  Fly  1322 MHLREDLALAARSASLISQPAENIAIVADMDKWDVRLISSQ-----TQQFPYAGGQSSPVGMSQL 1381
            ..|..||........|....||.:.|:||.|||.|::.:||     |.:.    ||.  |.:|..
Mouse  1023 QCLAADLVHTVHHPVLDEPIAEAVCIIADTDKWTVQVATSQRKVTDTMKL----GQD--VLVSSQ 1081

  Fly  1382 VSSMLETVQAMNAGGIPAYECLSFLESKLQEIYLQSETLAAFLLETDPCRLSDITNPLQLSENDV 1446
            |||:|:::..:....:||..|:..||.:|||:||:|:.|:.:|.......:.:::..|.:..||:
Mouse  1082 VSSLLQSILQLYKLHLPADFCIMHLEDRLQEMYLKSKMLSEYLRGHTRVHVKELSVVLGIESNDL 1146

  Fly  1447 PLLLSIAYIHTPKISR 1462
            |||.:||..|:|.:::
Mouse  1147 PLLTAIASTHSPYVAQ 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3764	NP_001261977.1	FNIP_N	101..226	CDD:464228	41/149 (28%)
		FNIP_M	461..692	CDD:434087	85/250 (34%)
		FNIP_C	1269..1461	CDD:464229	58/196 (30%)
Fnip2	NP_001392095.1	FNIP_N	69..191	CDD:464228	41/149 (28%)
		FNIP_M	350..583	CDD:434087	90/257 (35%)
		FNIP_C	978..1161	CDD:464229	66/244 (27%)