DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3764 and Fnip2

DIOPT Version :9

Sequence 1:	NP_001261977.1	Gene:	CG3764 / 39902	FlyBaseID:	FBgn0036684	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	XP_008759321.1	Gene:	Fnip2 / 310538	RGDID:	1562174	Length:	1170	Species:	Rattus norvegicus

Alignment Length:	1524	Identity:	342/1524 - (22%)
Similarity:	563/1524 - (36%)	Gaps:	468/1524 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GTATSATTTTLP------AR-TAHASAGVA---ATASAGNSSSSAKATKQTSRNYL----SRFPF 97
            |||.|   |..|      || ...|::||.   .|......|..|:..:.|:...|    |...|
  Rat     4 GTANS---TNWPVGQQESARCVTDATSGVGRIFKTLVCAKISKCARGGRDTNSMVLNHSWSCSEF 65

  Fly    98 EGSQVRVLLYKEDDT--RRLLFDSNALQKVMHKDQSAT-----------------SASISSTSTS 143
            :.|.:|:::|::.:.  |:::|||.|:|||   :::|.                 |.|:||:|:|
  Rat    66 DLSDIRLIVYQDCERRGRQVMFDSRAVQKV---EETAAQKAEDVPIKMSARCCQESGSVSSSSSS 127

  Fly   144 GGGKFLKNEKYTSLQNGKIPSKSHSSNGSNFIEVCAEY--GYKHNRPSGADITPVGEMVFGSLPM 206
            ....                |.|.||.||:  :...|.  .|::.||: :|:..:|||:|||:.|
  Rat   128 SSNS----------------SSSQSSGGSS--QHAKEQLPKYQYTRPA-SDVNMLGEMMFGSVAM 173

  Fly   207 SFCGTALKVHWLPEPSRILCSQVYLTPTSNGGS--GHSPYSTLSTNSLA---------------- 253
            |:.|:.||:|::..|.:::.|:|:   ::..||  |       |||:|.
  Rat   174 SYKGSTLKIHYIRSPPQLMISKVF---SARMGSFCG-------STNNLQDSFEYINQDPQAGKLN 228

  Fly   254 TPRTSI--CSEHGSMDGLSMNSFSMPFSVSVGRQMSLT----------PPLDVPATPADQQSLSI 306
            |.:.|:  |....::..|...|..:...||.|..:.||          .|:|:|:...::.
  Rat   229 TNQNSLGPCRTGSNLGLLQACSGKLLQGVSEGGPLRLTRSASFFAAHSTPVDMPSRGQNED---- 289

  Fly   307 HSIDSSGPRYSSTYSTATDSGYSASGSGSAAGGDQWSYQYSSTRSSLGSVLSDQSDAMRKLSMDL 371
                             .|||.:.|.|.|:.....:....|||.||
  Rat   290 -----------------RDSGIARSASLSSLLITPFPSPSSSTSSS------------------- 318

  Fly   372 ACYTGSPYLDGFASDGCLQRRISRNLRTSFENEHSKNDFIGFLSDNYALNGPVVAPAGGGAGGGS 436
                 |.|          |||..|:..||.||
  Rat   319 -----SSY----------QRRWLRSQTTSLEN--------------------------------- 335

  Fly   437 EGGGMAPPQYRRAS----YCANET-RSNPEMGRRQANLRRRAKLGLAVCISM--SESFEEEMELF 494
               |:.|   ||::    ..|.|| .|||       ::.||.|:.:::..|:  .|:.:.:.:.|
  Rat   336 ---GIFP---RRSTDETFSLAEETCSSNP-------SIVRRKKIAISIIFSLCEREAAQRDFQDF 387

  Fly   495 CSEHIALLESMLSRLRASTELAYIN----HKNFLQIMF------QAWQDTQQWFSDLFTAPRIKT 549
            ...|..|.||.::||:::.|.|.|:    .::.|::.|      :|..:.:....:|::.|||..
  Rat   388 FFSHFPLFESHMNRLKSAIEKAMISCRKISESSLRVQFYVSRLMEALGEFRGTIWNLYSVPRIAE 452

  Fly   550 PVWLSITTSGSKYSKTVAERFIKELCDLLSFADTKDSNFFISTMLTGILTHHLGWVATVSAFNSS 614
            ||||:: .|.:.....:.:||:||...|:   :..:.|.|.:.:||.:||:||.||.||...:..
  Rat   453 PVWLTM-MSNTLEKNQLCQRFLKEFILLI---EQVNKNQFFAALLTAVLTYHLAWVPTVMPVDHP 513

  Fly   615 GSKRSESSASAAAIEQRAKLLQVAQKHPYNALWAQLGDLYGAIGMPPKLARTIVCGAEKLWVEKL 679
            ..|......::.::...||      .||||.|||||||||||||.|.:|.||:|.|.:|..|:::
  Rat   514 PIKTFSEKRTSQSVNMLAK------THPYNPLWAQLGDLYGAIGSPVRLTRTVVIGKQKDLVQRI 572

  Fly   680 LNVLTYFIRCSEVRR-----AAKREDFNKQLINDL----------AAQSQTKNQTGTQERHKSPP 729
            |.|||||:||||::.     :....| :.|:||..          ..:|:....|.:.|....||
  Rat   573 LYVLTYFLRCSELQENQLTWSGNHSD-DDQVINGSKIVTALEKGEVEESEYVVVTVSNEPALVPP 636

  Fly   730 TQKRGLSRAATCKQNLNAIADDADDENGELNMYDRDNEDGDPDGLDSGSLDASDGMQTLKKNEIP 794
            ....|.|...:.:..:  :|:..:..|.||......|....|:.....|   |.|.|..:.:...
  Rat   637 VLPPGTSERTSPEPTV--VAEIPEGINTELGHKPERNRCKRPEQYSEAS---SMGFQEAETDNSW 696

  Fly   795 TVLAF-----RDSHFVQQELRIGNYLMDTGIDKKMLLARQAQQYFRTGKDGRIRLTVTTPDNVEL 854
            |....     ::...|.|:...|    ....:...:..|..||.|.....|.:           |
  Rat   697 TPRGMFCEDKQNDQQVAQDCSSG----PPSCEVPRVKRRMDQQTFHEELHGEM-----------L 746

  Fly   855 CMEEEQSSGTGSVSTGSVDDGAIEAIDYEDNVEAPPKKNF------FWNMVPVAGVKEGLSLSDL 913
            ....|:|:........|.:...:|.:.:.......|:.:|      ....:...|...|.|.|..
  Rat   747 KKRAERSAAWPCPDRHSQEGPPVEKVTFHIGSSISPESDFESRTKRMEERLKACGHFHGASASAR 811

  Fly   914 AKLQQGIRIINRKLERRSSSYSVEGNPDQQQSKTGETGVGDFEPLSHERRASHLSLSDLITQNSM 978
            :.:..|:                    .|.|..:|.:...||:             .|:..|:.
  Rat   812 SSMDTGL--------------------TQDQQASGCSFKADFQ-------------KDITPQDH- 842

  Fly   979 GKSDRMTWGIEPIKENVSLEEQIHFDHCHKLIEREHGICRQTSADNGNGVVFVLGDNEPLINLKK 1043
                  ..|.|.:.||..|...|..:..|.:        .|.|..:|           ||.....
  Rat   843 ------CLGEEGVSENRGLRANIRANMAHAV--------GQLSQADG-----------PLAPSTC 882

  Fly  1044 SSEDLSGDQDSKPTLMLCAQHQRTHDRSKHSGMKFNFEQYPQIATNYMKNKNLLMSNYDLLMDKV 1108
            ::|  ||          ..|.::|.|.........:.|..|          |......|||:  .
  Rat   883 TAE--SG----------WRQLEQTRDVQLKGNKGPSSEPVP----------NRCRQQGDLLI--A 923

  Fly  1109 TKLEASEAAALKGSDSTATLAASSSSTAALLPPTTPVTANSDRCVVCSSGVGINTSATWNQTPSN 1173
            ..:...:|:......|...:..:.|..:||      ..::.:.||:....:|.|
  Rat   924 ADVPYGDASGKANYRSEGDIPRNESLDSAL------GDSDDEACVLALLELGHN----------- 971

  Fly  1174 ATELEFETDEMHCYNQSGNGNGFSSKALQSVNSAASIDTLKSSVAVEPPTPTIPTQMQTTYMRKQ 1238
                        |                        |..:.|..||.|.|           |.|
  Rat   972 ------------C------------------------DRTEGSFEVELPLP-----------RSQ 989

  Fly  1239 QPKRVPSGRSSVSSVAAKCAAVNVSQQLLKLPVPGIKELPQDDESPGDQLRAGFIPSLLLSVSDH 1303
            ...:                             |.::..       |..|.||:..:
  Rat   990 STSK-----------------------------PNVRNF-------GRSLLAGYCAT-------- 1010

  Fly  1304 YVSDMVLQGTCAPPNKWEMHLREDLALAARSASLISQPAENIAIVADMDKWDVRLISSQTQQFPY 1368
            |:.|:||.|| :...|.:..|..||........|....||.:.|:||.|||.|::.:|| ::...
  Rat  1011 YMPDLVLHGT-SSDEKLKQCLAADLVHTVHHPVLDEPIAEAVCIIADTDKWTVQVATSQ-RKVTD 1073

  Fly  1369 AGGQSSPVGMSQLVSSMLETVQAMNAGGIPAYECLSFLESKLQEIYLQSETLAAFLLETDPCRLS 1433
            |......|.:|..|||:|:::..::...:||..|:..||.:|||:||:|:.|:.:|.......:.
  Rat  1074 AMKLGQDVLVSNQVSSLLQSILQLHKLHLPADFCIMHLEDRLQEMYLKSKMLSEYLRGHTRVHVK 1138

  Fly  1434 DITNPLQLSENDVPLLLSIAYIHTPKISR 1462
            :::..|.:..:|:|||.:||..|:|.:::
  Rat  1139 ELSVVLGIESSDLPLLTAIASTHSPYVAQ 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3764	NP_001261977.1	FNIP_N	101..222	CDD:291310	40/141 (28%)
		FNIP_M	461..692	CDD:291311	81/242 (33%)
		FNIP_C	1269..1460	CDD:291312	56/190 (29%)
Fnip2	XP_008759321.1	FNIP_N	69..189	CDD:291310	40/141 (28%)
		FNIP_M	352..585	CDD:291311	86/249 (35%)
		FNIP_C	983..1166	CDD:291312	60/239 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343904
Domainoid	1	1.000	138	1.000	Domainoid score	I4719
eggNOG	1	0.900	-	-		E1_KOG3693
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2763
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D156423at33208
OrthoFinder	1	1.000	-	-		FOG0002940
OrthoInspector	1	1.000	-	-		otm44486
orthoMCL	1	0.900	-	-		OOG6_104859
Panther	1	1.100	-	-	LDO	PTHR21634
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2303
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.850