DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3764 and Fnip1

DIOPT Version :9

Sequence 1:	NP_001261977.1	Gene:	CG3764 / 39902	FlyBaseID:	FBgn0036684	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	NP_776114.2	Gene:	Fnip1 / 216742	MGIID:	2444668	Length:	1165	Species:	Mus musculus

Alignment Length:	1447	Identity:	321/1447 - (22%)
Similarity:	537/1447 - (37%)	Gaps:	402/1447 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 FEGSQVRVLLYKEDDT--RRLLFDSNALQKVMHKDQSATSASISSTSTSGGGKFLK----NEKYT 155
            |:.||:|:::|::.:.  |.:||||:..:|   .:.::.|...:.......||..:    .:..:
Mouse    37 FDPSQIRLIVYQDCERRGRNVLFDSSVKRK---NEDTSVSKLCNDAQVKVFGKCCQLKPGGDSSS 98

  Fly   156 SLQNGKIPSKSHSSNGSNFIEVCAEYGYKHNRPSGADITPVGEMVFGSLPMSFCGTALKVHWLPE 220
            ||.:    |.:.||:|.   :.|.:  |:.:|.| :|...:|||:|||:.||:.|:.||:|.:..
Mouse    99 SLDS----SITLSSDGK---DQCPK--YQGSRCS-SDANMLGEMMFGSVAMSYKGSTLKIHQIRS 153

  Fly   221 PSRILCSQVYLTPTSNG--GSGHSPYSTL-----STNSLATPRTSICSEHGSMDGLSMNSFSMPF 278
            |.:::.|:|:...|.:.  ||.::...:|     .:|:|....:::  .:|.:..:.::.|..|
Mouse   154 PPQLMLSKVFTARTGSSICGSLNTLQDSLEFINQDSNTLKADSSTV--SNGLLGNIGLSQFCSP- 215

  Fly   279 SVSVGRQMSLTPPLDVPATPADQQSLSIHS--IDSSGPRYSSTYSTATDSGYSASGSGSAAGGDQ 341
                .|..|...||.:..:.:   ..::||  :|..|...:..    .|||.:.|.|.|:.
Mouse   216 ----RRAFSEQGPLRLIRSAS---FFAVHSNPMDMPGRELNED----RDSGIARSASLSSL---- 265

  Fly   342 WSYQYSSTRSSLGSVLSDQSDAMRKLSMDLACYTGSPYLDGFASDGCLQRRISRNLRTSFENEHS 406
            :...:.|..|||                ..:|  .|.|          |||..|:..||.||
Mouse   266 FITPFPSPNSSL----------------TRSC--ASSY----------QRRWRRSQTTSLEN--- 299

  Fly   407 KNDFIGFLSDNYALNGPVVAPAGGGAGGGSEGGGMAPPQYRRASYCANETRSNPEMGRRQANLRR 471
                                             |:.|......|:..::....|..|     :.|
Mouse   300 ---------------------------------GVFPRWSVEESFNLSDESCGPNPG-----IVR 326

  Fly   472 RAKLGLAVCISMSESFEEEMEL--FCSEHIALLESMLSRLRASTE----------------LAYI 518
            :.|:.:.|..|:|:..:|..:.  |...|..|.||.:::|:::.|                |||
Mouse   327 KKKIAIGVIFSLSKDEDENNKFNEFFFSHFPLFESHMNKLKSAIEQAMKMSRRSADASQRSLAY- 390

  Fly   519 NHKNFLQIMFQAWQDTQQWFSDLFTAPRIKTPVWLSITTSGSKYSKTVAERFIKELCDLLSFADT 583
                  ..:..|..:.:....:|:|.|||..||||:: .||:.....:..||:||...|:   :.
Mouse   391 ------NRILDALTEFRTTICNLYTMPRIGEPVWLTM-MSGTPEKNQLCHRFMKEFTFLM---EN 445

  Fly   584 KDSNFFISTMLTGILTHHLGWVATVSAFNSSGSK---RSESSASAAAIEQRAKLLQVAQKHPYNA 645
            ...|.|:..::|.:||:||.||.||........|   ...||.|..         .:|:.||||.
Mouse   446 ASKNQFLPALITAVLTNHLAWVPTVMPNGQPPIKIFLEKHSSQSVG---------MLAKTHPYNP 501

  Fly   646 LWAQLGDLYGAIGMPPKLARTIVCGAEKLWVEKLLNVLTYFIRCSEVRRAAKREDFNKQLINDLA 710
            |||||||||||||.|.:||||:|.|..:..|::||..|||||||||::.....|:...:.|....
Mouse   502 LWAQLGDLYGAIGSPVRLARTVVVGKRQDLVQRLLYFLTYFIRCSELQETHLLENGEDEAIVMPG 566

  Fly   711 AQSQTKNQTG----------TQERHKSPPTQKRG-LSRAATCK----------QNLNAIA----D 750
            ....|..:.|          |..|:||....|.. .:|...|.          ||...::    :
Mouse   567 TVITTTLEKGEIEESEYVLITMHRNKSSLLFKESEETRTPNCNCKYCSHPVLGQNTENVSQPERE 631

  Fly   751 DADDENGE-LNMYDRDNEDGDPDGLDSGSLDAS---DGMQTLKKNEIPTVLAFRDSHFVQQELRI 811
            |..|.:.| |.:.|...:...||..:..::|..   |.::|....::.||:.            .
Mouse   632 DTQDNSKELLGISDECQKISPPDCQEENAVDVQQYRDKLRTCLDTKLETVVC------------T 684

  Fly   812 GNYLMDTGIDKKMLLARQAQQYFRTGKDGRIRLTVTTPDNVELCMEEEQSSGTGSVSTGSVDDGA 876
            |:...|..:..:..|..:.:.:                .|.|| ::.:..:||....||.|.:
Mouse   685 GSAPADKCVLSETCLEPREESW----------------QNKEL-LDSDNHTGTAMRPTGIVVE-- 730

  Fly   877 IEAIDYEDNVEAPPKKNFFWNMVPVAGVKEGLSLSDLAKLQQGIRIINRKLERRSSSYSVEGNPD 941
                      :.||.||     ||                               |::|.|....
Mouse   731 ----------KKPPDKN-----VP-------------------------------SAFSCEVTQT 749

  Fly   942 QQQSKTGETGVGDFEPLSHERRASHLSLSDLITQNSMGKSDRMTWGIEPIKENVSLEEQIHFDHC 1006
            :.....|::    ..|.|.....|...:..:...:|           ||:||:..:.::
Mouse   750 KVTFLIGDS----MSPDSDTELRSQAVVDQINRHHS-----------EPLKEDRGVADK------ 793

  Fly  1007 HKLIEREHGICRQTSADNGNGVVFVLGDNEPLINLKKSSEDLSGDQDSKPTLMLCAQHQRTHDRS 1071
                .:|..|.:..|.|:         |.:.::         ||:....|    |..|......|
Mouse   794 ----HQESKITKDQSEDS---------DTQNIV---------SGESCELP----CWSHSDPESMS 832

  Fly  1072 KHSGMKFNFEQYPQIATNYMKNKNLLMSNYDLLMDKVTKLEASEAAALKGSDSTATLAASSSSTA 1136
                                            |.|:....::.|...:  .|.....:..|....
Mouse   833 --------------------------------LFDEYFNDDSIETRTI--DDVPVKTSTDSKEYC 863

  Fly  1137 ALL--PPTTPVTANSDRCVVCSSGVGINTSATWNQTPSNATELEFETDEMHCYNQSGNGNGFSSK 1199
            .:|  |.......|..:..:|      ....|.:|...||           |:.|....|..|
Mouse   864 CMLEYPKRLYTKTNKQKSELC------KCIETVHQDSCNA-----------CFPQQDQRNSLS-- 909

  Fly  1200 ALQSVNSAASIDTLKSSVAVEPPTPTIPTQMQTTYMRKQQPKRVPSGRSSVSSVAAKCAAVNVSQ 1264
            .|.......|.|. |::|..|...|                 |..|..|::....::....::.:
Mouse   910 ILVPHGDKESSDK-KNAVGTEWDIP-----------------RNESSDSALGDSESEDTGPDIRR 956

  Fly  1265 QL--------------LKLPVPGIKELPQDDESPGDQLRAGFIPSLLLSVSDHYVSDMVLQGTCA 1315
            |.              .::|.||.|.:......|.   .|.|..|||......||.|.|||| ..
Mouse   957 QAGGYCGGDQEDWTEEDEIPFPGSKLIEVSAVQPN---IANFGRSLLGGYCSSYVPDFVLQG-IG 1017

  Fly  1316 PPNKWEMHLREDLALAARSASLISQPAENIAIVADMDKWDVRLISSQTQQFPYAGGQSSPVGMSQ 1380
            ...:....|..||:.|.:...|....||.:.|:||||||.|::.|||.:......|:.  |.:|.
Mouse  1018 NDERLRQCLVSDLSHAVQHPVLDEPIAEAVCIIADMDKWTVQVASSQRRVTDNKLGKE--VLVSS 1080

  Fly  1381 LVSSMLETVQAMNAGGIPAYECLSFLESKLQEIYLQSETLAAFLLETDPCRLSDITNPLQLSEND 1445
            |||::|.:...:....:....|:..||.:|||:|.:|:.|:.:|.......:.::...|.:..:|
Mouse  1081 LVSNLLHSTLQLYKHNLSPNFCVMHLEDRLQELYFKSKMLSEYLRGQMRVHVKELGVVLGIESSD 1145

  Fly  1446 VPLLLSIAYIHTPKISR 1462
            :|||.::|..|:|.:::
Mouse  1146 LPLLAAVASTHSPYVAQ 1162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3764	NP_001261977.1	FNIP_N	101..222	CDD:291310	35/126 (28%)
		FNIP_M	461..692	CDD:291311	85/251 (34%)
		FNIP_C	1269..1460	CDD:291312	60/190 (32%)
Fnip1	NP_776114.2	FNIP_N	41..155	CDD:291310	35/126 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..118		7/34 (21%)
		FNIP_M	316..548	CDD:291311	86/256 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..811		10/61 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	912..970		10/75 (13%)
		Interaction with HSP90AA1. /evidence=ECO:0000250\|UniProtKB:Q8TF40	928..1165		66/258 (26%)
		FNIP_C	975..1161	CDD:291312	60/191 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840046
Domainoid	1	1.000	137	1.000	Domainoid score	I4863
eggNOG	1	0.900	-	-		E1_KOG3693
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2762
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D156423at33208
OrthoFinder	1	1.000	-	-		FOG0002940
OrthoInspector	1	1.000	-	-		otm42421
orthoMCL	1	0.900	-	-		OOG6_104859
Panther	1	1.100	-	-	O	PTHR21634
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2303
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.850