DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and FGD3

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_001077005.1	Gene:	FGD3 / 89846	HGNCID:	16027	Length:	725	Species:	Homo sapiens

Alignment Length:	557	Identity:	113/557 - (20%)
Similarity:	204/557 - (36%)	Gaps:	110/557 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1425 SPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSLFS 1489
            |.||    :.||.|.      .|..|:..| |...:|......:..|..|..||.:|.......|
Human     3 SGRG----SSTPPGP------IAALGMPDT-GPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGS 56

  Fly  1490 NE--PLYQMYSAAKLESITRDLEAHGSSDGYE----EIGLQAKAKPEPLVKPRPTALQLVEPKNG 1548
            .:  |..::..:.|:.:....:::..||...|    |.||:|...|..|......||....||..
Human    57 PDIGPTGELSGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKVT 121

  Fly  1549 PSRTLWSEIPEVIHSCILPTLTSRERSLQE---------AKFEIITSEASYLKSLNLLRRHFMNH 1604
            |.....|::.|...|...|....::..|.:         ...|::.:|.:|:|.|:||.:.|...
Human   122 PQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFCTR 186

  Fly  1605 --NAFLDSSVLSAKDRKALFSYIVPVHEC-SERLLTELEAC----WQDNIMLLGLSRCIYEIAER 1662
              :|.:...|:     ..:||.|..:|.. .:.||.||:..    |..|..|       .:|.::
Human   187 LTDAGIPPEVI-----MGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRL-------GDILQK 239

  Fly  1663 HFHVYVAFCEHQGRMDRTLRRLKE-SKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLP 1726
            .......:.|:....||.:..:.. ::.|..|:..:..::....|..|.|...::.|:||:.|..
Human   240 LAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYE 304

  Fly  1727 LLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALA 1791
            ||:.. :.|..|.:..:.:..:.:|.|:.......|.|..:.|:..:|..:..||.....:
Human   305 LLLKD-YLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEEDI---- 364

  Fly  1792 IAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLC----KRRG 1852
            :.|...         |:|.|::..|          ..|..|....:.|||:.::|.|    :..|
Human   365 VNPANE---------LIKEGQIQKL----------SAKNGTPQDRHLFLFNSMILYCVPKLRLMG 410

  Fly  1853 ESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQ 1917
            :. |||     |..:.::.      |..:|:......:..::|     .||. .|.|...:..::
Human   411 QK-FSV-----REKMDISG------LQVQDIVKPNTAHTFIIT-----GRKR-SLELQTRTEEEK 457

  Fly  1918 QRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESD 1954
            :.|:|.::                  ..:.||...|:
Human   458 KEWIQIIQ------------------ATIEKHKQNSE 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	40/189 (21%)
		PH_ephexin	1805..1931	CDD:269929	25/129 (19%)
		SH3_ephexin1_like	1944..1998	CDD:212727	3/11 (27%)
FGD3	NP_001077005.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..151		38/158 (24%)
		RhoGEF	160..339	CDD:238091	40/191 (21%)
		PH1_FGD3	371..478	CDD:275422	28/152 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..532
		FYVE_FGD3	531..584	CDD:277279
		PH2_FGD1-4	598..702	CDD:270056
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	703..725
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810