Protein Alignment Exn and Nost

DIOPT Version :10

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_001285029.1
• Gene: Nost / 8673992
• FlyBaseID: FBgn0259734
• Length: 1330
• Species: Drosophila melanogaster
• Alignment Length: 1440
• Identity: 267/1440 - (18%)
• Similarity: 443/1440 - (30%)
• Gaps: 466/1440 - (32%)

  Fly    65 NNRATCDKAGKDNPNPNQNPNSQANPNQNCSCESRAFRDFRGVQTLRLLWSRRIKSAS------- 122
            :|.|..|....:| ..|.|.|..:|.||....:....|..|.......|..|.:.|.:
  Fly   120 DNAAMADLPQSEN-TTNNNNNIGSNNNQKGGAKGFLGRIKRYSVLGNKLGRRNLGSMNLNPPNNV 183

  Fly   123 EDQCHSPVHCHT-----------------------SSSSLGT---------LKKLNKSVSCLVNA 155
            .|...||...||                       |:::|.|         ||::...::
  Fly   184 VDNSVSPTKLHTGSYNMTGSHSDDHRLEIGAPILISTTTLDTDRFDVTEARLKQIGGGIA----- 243

  Fly   156 FNNSRDCATPEKTLAKRAASLHNLQDSQAKHKQLHREKD-------------------------- 194
                 ..::..:||..|::......|:::..:|:.|::|
  Fly   244 -----QTSSIVRTLTPRSSDEEEFVDARSSPQQMERDEDLQIADDQVEKNDRDQYGHQFQLPKKQ 303

  Fly   195 ------NFYKY-KNAEQAKMQAKLRSSADEAILNASETRAKRDDSGCLPGVKSYNSKALSAAD-- 250
                  ...|| .:.|:.:.....:...:|.:|.|::            .||...:....|.|
  Fly   304 HREEEMGDLKYLDDLEEPEQFETPKHEVEEKLLTANQ------------DVKRPITPITIAIDPP 356

  Fly   251 -KVAKVAKGEAKTQ-----RRAEEPV-----GEAEVEVEVEFRAKREHNRLEGLSLSAASAQS-- 302
             :..::|:.:.::|     .|:|..|     ....:::.|...||.      ||.|:......
  Fly   357 IRRPRIARQQRQSQSVQNLHRSELKVYLHKSNSVALDMNVTAPAKL------GLDLNLPELPELY 415

  Fly   303 GGSSESLQTTTTSSSTPTTHSSVTSSTGRSGG--------RRKYSF----KTHAGKSYHQHHHPS 355
            |.|..||..:....:.|....|...|...:||        :...||    ::|:.:|..|   .|
  Fly   416 GASELSLAASDNKENLPAVKPSAERSPIPNGGFMAQQPHFKSLDSFHLNTRSHSNQSSQQ---SS 477

  Fly   356 RRTSNMDSSNG---------------------GISMVAKLTHQFNEI-----------------I 382
            |::....||||                     .|..:.:||.|.||.                 :
  Fly   478 RQSLACSSSNGEYDFDLKSVSYQSLNAQNLFVSIDELQELTRQINETEDFGKEIDLEYCAHRDQL 542

  Fly   383 QKDAKLLEQVKRNNGVWIS---------RGTHVYK--IVEKPTSEGKGLPNADDNRISTVQRNIK 436
            :...:.:..:|..|...|:         :|.|..|  :.|    ||                  .
  Fly   543 RPSERRITLLKNKNQTLINFNHNKEKLRKGWHGMKHWLGE----EG------------------S 585

  Fly   437 KFERLEKPSVPLKSEQLMRKHL--ELMRGSSLSRGP-RIKRNLKLPPGSVGIPELAIVSEELKTP 498
            |.:...:...|||.....|.:|  .....|..|..| |.:|:  :......:.|...:...:...
  Fly   586 KIKEAVRQQTPLKRLAQSRSNLNQSTADASRQSMSPERTQRD--VTESCEDVTERTEMESSMSHR 648

  Fly   499 TSEEQ-AKKPKSVQNESQPNHPEEL----NQSNDKPSDELDLIMGEEGDEEELRQKQRKHKYASI 558
            .|||. :...|..::|.| |..|||    .|..|. |.||..::.|..|.|.:        |:..
  Fly   649 NSEEDLSPHAKRFKDEGQ-NGFEELRRYVKQGGDF-SKELIFVLQERADSELI--------YSKS 703

  Fly   559 YEKLRFTFAKGRKSASPSPTKAQIREEVSIDEESIKDSTSEDMVTRKEDFTLDLPKEVIPRAEDL 623
            ..||.....|..:....|...|.  ..|:.:.||..|      :.|:  ....|..|::...:.:
  Fly   704 LSKLANKLNKAGREIPGSVADAW--RGVATEMESRSD------IHRQ--LAASLTDELVKPLKIV 758

  Fly   624 EDSSHAL--LVSPCFEADAKILDALEAVDLKLKVLNPLNDVTTADGERELLLAANDDFEQRILPN 686
            .:..|..  .|....:..|::|....|.:.|.|..:     .||..|.|.|..|..|...:..|:
  Fly   759 VEGHHKARKAVESNVDKAARVLGEWRASEAKAKKAS-----HTAARENEKLQDAMLDVRIQKSPS 818

  Fly   687 SSFVYQAANKQYSNNQILLNQAVNVTLVNAIEGEQMIMEQKQLMKVRDLELTERD---IDQPLKR 748
            .:.::|..|||.:.                                ::|:..|:|   :|...|:
  Fly   819 IALLHQGPNKQAAE--------------------------------KELKSAEKDCVKLDNKRKK 851

  Fly   749 AEKSPEKDD----TLEPESLYEPITPVMDETKTEAQTSSLFKIYTKKSELVEDIYQTVEEASTVE 809
            ||::.::.|    ||...|....:...|...:..||..|      .:.:.:.:::...::.:.:.
  Fly   852 AEEAVKRADVEYYTLCVRSERARVDWEMAVLRGSAQLQS------SEQQRLGNMHNFAQQYARLI 910

  Fly   810 VKPNNWLEGYESIAGSQ-EACPLTYD-------GYESFAPEEVVTTPTTPSATGTLGRNTRDELP 866
            ...|..|.|..:....| :||.:..|       ...|..|.|.: .|.......||..|......
  Fly   911 SDMNPILGGLSTRLQPQLDACNVAKDMQVVRHIRRNSEGPSEQL-LPDFYCEHTTLAMNRERRKH 974

  Fly   867 ELPKPKRVL-------NKSPIPLRPAPPKPQAKESEEDENIYDTIKGCYESMHCKATSSSSSG-- 922
            .|.|..:::       .:|...||..   .|:...:|.:||.|.:      .|.::..:...|
  Fly   975 ALIKLLQLVKTDLERERRSRDGLRGL---SQSLNHQEHQNITDKL------YHIRSMLTYLEGAR 1030

  Fly   923 ----EATLTTDTISLSSNCYESISHIRRSRVATTQ------NQGHGSAGSCIQLSSSGSTLTISS 977
                .|.|..|....:::......||.|.|....|      |....:..|..|.|:|.....| :
  Fly  1031 LKLHSALLELDHKPRATHPLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQTQQSTSMLAHDI-T 1094

  Fly   978 DHKTNSLYESSLAAAGCVVYGSASVGCRSSLGSSAGSRDSGKPGDKRSSIAGSSDNSDAWVDISD 1042
            |..||  :|..|....|....|:|....:|.||........||.::..|            :|..
  Fly  1095 DITTN--HEDELPDENCSHLHSSSHSNNNSNGSCTDVSSVVKPFNRSKS------------NIET 1145

  Fly  1043 GEIGQATTDATANEAQFIVVRERFKPHRTRSPDWSKRIRDKRLQQKKAISCIEDDSDHYYETLSP 1107
            ....|....:|.|.|..:.|:.:                                      ||:.
  Fly  1146 NFTSQPKIISTTNAAIAVSVKSK--------------------------------------TLAN 1172

  Fly  1108 LGNKRHSTQLVRQSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSFET-DSDDHGDGE 1171
            |.:..|:.|              :..|....:||......|.......|:|.|.: |.||    |
  Fly  1173 LQDGHHNNQ--------------QHHHHHHNHHSDRGQADGGSNQQDSDFDEFSSQDEDD----E 1219

  Fly  1172 PDLRQRNYNDSGVDMRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKLYENTPASTLFY 1236
            |...|:               :|.|.|:|                  :..||.|.:|..
  Fly  1220 PQQPQQ---------------QPQPLQSQ------------------QQQQQPLLQNPT------ 1245

  Fly  1237 VECSKRTEDVYENTDFGPERIPAPETKGPVHQEQAPVLRAKQKNG--------KSLRSRLRKSLV 1293
            :....:|:..|:|                     |..|:..||||        |:|.|...|
  Fly  1246 INGQVQTQHFYQN---------------------AQELQKGQKNGSVPILGRCKALYSYTPK--- 1286

  Fly  1294 GSSFDTKQLS 1303
              .:|..:||
  Fly  1287 --LYDELELS 1294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1762	CDD:459876
		PH_ephexin	1805..1931	CDD:269929
		SH3_ephexin1_like	1944..1998	CDD:212727
Nost	NP_001285029.1	F-BAR_NOSTRIN	663..908	CDD:153342	61/307 (20%)
		SH3_Nostrin	1276..1328	CDD:212757	7/24 (29%)