Protein Alignment Exn and ROM2

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_013475.1
• Gene: ROM2 / 851086
• SGDID: S000004363
• Length: 1356
• Species: Saccharomyces cerevisiae
• Alignment Length: 1225
• Identity: 215/1225 - (17%)
• Similarity: 409/1225 - (33%)
• Gaps: 369/1225 - (30%)

  Fly  1018 GKPGDKRSSIAGSSDNSDAWVDISDGEIGQATTDATANEAQFIVVRERFKPHRTRSPDWSKRIRD 1082
            |...|..|.|.|.....|::........|..::....|..:.|.     ..:...|.|.:..|..
Yeast    10 GDRNDIYSQIFGVERRPDSFATFDSDSHGDISSQLLPNRIENIQ-----NLNVLLSEDIANDIII 69

  Fly  1083 KRLQQKKAISCIEDDSD-----------HYYETLSPLGNKRHSTQLVRQSQDGNRSGGVRSSHRR 1136
            .:.:::..:....||||           :|  .||...|.:.    |..:|..:.:.....|..:
Yeast    70 AKQRRRSGVEAAIDDSDIPNNEMKGKSSNY--ILSQQTNIKE----VPDTQSLSSADNTPVSSPK 128

  Fly  1137 SKNHSASAHTLGEHVVISDDYDSFETDSDDHGDGEPDLRQ-RNYNDSGVDMRNHRLPKPPPPQNQ 1200
            ....:.|:|.:.....:|..|.:..:.|          || ::|||       |.|| |..|:|:
Yeast   129 KARDATSSHPIVHAKSMSHIYSTSNSAS----------RQAKHYND-------HPLP-PMSPRNE 175

  Fly  1201 VYEFVRKFKDFISSKKSPKGSQ--------QKLYENTPASTL-------------FYVECSKRTE 1244
            ||:..:....|: .|:.|...|        |..:....|||.             |:...|  ::
Yeast   176 VYQKNKSTTAFV-PKRKPSLPQLALAGLKKQSSFSTGSASTTPTQARKSPLQGFGFFSRPS--SK 237

  Fly  1245 DVYE---------------------NTDFGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRL 1288
            |::|                     |.:....::.:..:..|.|..... .|:...|..:|::
Yeast   238 DLHEQHQHHQHIQHNNINNHNNNNTNNNGAHYQVGSSNSNYPQHSHSIS-SRSMSLNSSTLKN-- 299

  Fly  1289 RKSLVGSSFDTKQLSSLAPTRSTFYVEDP-------------EGSLPALPLEPEIHGSGELDS-- 1338
                :.|||.:|..:|...|:......:|             ..|..:|   ..:||||...|
Yeast   300 ----IASSFQSKTSNSRKATQKYDITSNPFSDPHHHHHHHHSSNSHSSL---NNVHGSGNSSSVM 357

  Fly  1339 GFSD---------------------------------KNCTPLPET-PKFSTVARKAK------- 1362
            |.|.                                 .:.|||..: |..|..::|.:
Yeast   358 GSSSNIGLGLKTRVSSTSLALKRYTSVSGTSLSSPRRSSMTPLSASRPVMSASSKKPQVYPALLS 422

  Fly  1363 KEAKANRRRTTIGLRPNDPPPPPPPMTGNKS---------------PLDPERELDAEQTTSWYAE 1412
            :.|...:....:|....|........||.::               .|...|.|||::
Yeast   423 RVATKFKSSIQLGEHKKDGLVYRDAFTGQQAVDVICAIIRTSDRNLALLFGRSLDAQK------- 480

  Fly  1413 CGVFKQAT---------------------NGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSG 1456
              :|....                     .|..|....:|:...|:.    ||:.:.:..|..||
Yeast   481 --LFHDVVYEHRLRDSPHEVYEFTDNSRFTGTGSTNAHDPLMLLPNS----SSFNSGNHSYPNSG 539

  Fly  1457 ISVASSSGSS-----GVSTGNEAGLGDELSSE--PHSLFSNEPLYQMYSAAKLESITRDLEAHGS 1514
            : |.|||.||     ...||:...:...||.:  |.::.:...::.:.:.....:.|||...:..
Yeast   540 M-VPSSSTSSLNSDQATLTGSRLHMSSSLSQQKNPAAIHNVNGVFTLLAECYSPTCTRDALCYSI 603

  Fly  1515 SDGYEEIGLQAK--AKPEPLVKPRPTALQLVEPKNGPSRTL------WSEIPEVIHSCILPTLTS 1571
            |.. ..:..||:  .||...:|...:.....:.:..||.|.      |..:|:
Yeast   604 SCP-RRLEQQARLNLKPNGGLKRNISMALDDDDEEKPSWTSSVSKEDWENLPK------------ 655

  Fly  1572 RERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDR----KALFSYIVPVHECS 1632
            :|...|||.:|:..:|.:::|||.:.|..||  ....:::::||..|    |.:|::|..::..:
Yeast   656 KEIKRQEAIYEVYITEKNFVKSLEITRDTFM--KTLAETNIISADIRKNFIKHVFAHINDIYSVN 718

  Fly  1633 ERLLTELEACWQDNIMLLGLSRCIYE-----------IAERHFHVYVAFCEHQGRMDRTLRRLKE 1686
            .|.|..|....:.:.::.|:...:..           :|.|.:..|:  .|.|..::....|..:
Yeast   719 RRFLKALTDRQRSSPVVRGIGDIVLRFIPFFEPFVSYVASRPYAKYL--IETQRSVNPYFARFDD 781

  Fly  1687 SKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESP-LNREEYESWKLT 1750
            ...|.:.:..::              |||...:.|..|..||:..:.....| .::.:||.....
Yeast   782 DMMSSSLRHGID--------------SFLSQGVSRPGRYMLLVKEIMKSTDPEKDKSDYEDLSKA 832

  Fly  1751 LALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTH 1815
            :..::..:.:.::|:...:...:::.:.:::.|.:....|.:..              :|.::.|
Yeast   833 MDALRDFMKRIDQASGAAQDRHDVKLLKQKILFKNEYVNLGLND--------------ERRKIKH 883

  Fly  1816 --LLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCF---SVFDY-CPRSMLTLAAGDS 1874
              :|.|.|.:| :.|..:..|..|  |..::||..|.:..:.:   .||.. .|..:|....|:.
Yeast   884 EGILSRKELSK-SDGTVVGDIQFY--LLDNMLLFLKAKAVNKWHQHKVFQRPIPLPLLFACPGED 945

  Fly  1875 LPQLP--TKDLKDQAG------------KNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMR 1925
            :|.|.  ..|..|.:|            ||.|  |.|....::..::.|.....:..|..|:.::
Yeast   946 MPALRKYIGDHPDCSGTVIQPEYNTSNPKNAI--TFLYYGAKQRYQVTLYAAQYAGLQTLLEKIK 1008

  Fly  1926 PPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGW 1990
            ..:|              .:::|               .::.||: |:.|.::
Yeast  1009 QGQA--------------AIISK---------------TEMFNVT-KMSDRFF------------ 1031

  Fly  1991 FPGSYTEELNSAH---------------------VRARNLKQRHRLLTFTATYLE 2024
               .||.::||..                     .|.:|...||:...|.:|.::
Yeast  1032 ---DYTNKINSVTSCDGGRKLLIATNSGLYMSNIKRQQNKDHRHKSSAFFSTPIQ 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	35/197 (18%)
		PH_ephexin	1805..1931	CDD:269929	32/145 (22%)
		SH3_ephexin1_like	1944..1998	CDD:212727	7/53 (13%)
ROM2	NP_013475.1	ROM1	4..1356	CDD:227709	215/1225 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840