DRSC/TRiP Functional Genomics Resources

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Protein Alignment Exn and ARHGEF5

DIOPT Version :9

Sequence 1:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster
Sequence 2:NP_005426.2 Gene:ARHGEF5 / 7984 HGNCID:13209 Length:1597 Species:Homo sapiens


Alignment Length:1961 Identity:444/1961 - (22%)
Similarity:708/1961 - (36%) Gaps:505/1961 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 LQDSQAKHKQLHREKDNFYKYKNAEQ----AKMQAKLRSSADEAILNASETR---AKRDDSGCLP 236
            ::.||.....|..::|....||..|:    |..|::||...|.||    ||.   .|...:...|
Human    28 MRSSQVSALGLEAQEDEDPSYKWREEHRLSATQQSELRDVCDYAI----ETMPSFPKEGSADVEP 88

  Fly   237 GVKSYNSKALSAADKVAKVAKGEAKTQRRAEEPVGEAEVEVEVEFRA---KREHNRLEGLSLSAA 298
            ..:|..::|....:....|.:..|..|.|...|         .|..|   :.||     |.::..
Human    89 NQESLVAEACDTPEHWEAVPQSLAGRQARTLAP---------PELWACPIQSEH-----LDMAPF 139

  Fly   299 SAQSGGSSESLQ-----TTTTSSSTPTTHSSVTSSTGRSGGRRKYSFKTHAGKSYHQHHHPSRRT 358
            |:..|...|.::     |:.|..|........||| ..||..|.||         ....||:...
Human   140 SSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSS-DNSGQTRYYS---------PCEEHPAETN 194

  Fly   359 SNMDSSNGGISMVAKLTHQFNEIIQ-----KDAKLLEQVKRNNGVWISRGTHVYKIVEKPTSEGK 418
            .|..|.:|.|....:|..:..:..|     ::.::||:..:....:...||    :.|...::|.
Human   195 QNEGSESGTIRQGEELPPEELQESQGLLHPQEVQVLEEQGQQEAGFRGEGT----LREDVCADGL 255

  Fly   419 GLPNADDNRISTVQRNIKKFERLEKPSVPLKSEQLMRKHLELMRGSSLSRGPRIKRNLKLPPGSV 483
               ..::..|..|  |.:|.|:.:      |.||:.    ::|.|   .:|.|:        |..
Human   256 ---LGEEQMIEQV--NDEKGEQKQ------KQEQVQ----DVMLG---RQGERM--------GLT 294

  Fly   484 GIPELAIVSEELKTPTSEEQAKKPKSVQNESQPNHPEELNQSNDKPSDELDLIMGEE-----GDE 543
            |.||.....|       .||....:..|.:..|...||..:....|.:.......|:     |..
Human   295 GEPEGLNDGE-------WEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKS 352

  Fly   544 EELRQKQRKHKYASIYEKLRFTFAKGRKSASP---------SPTKAQIREEVSIDEESIKDSTSE 599
            ||:..||..|   .|.||  .....|:::..|         :..:|:.|||              
Human   353 EEVTGKQEDH---GIKEK--GVPVSGQEAKEPESWDGGRLGAVGRARSREE-------------- 398

  Fly   600 DMVTRKEDFTLDLPKEVIPRAEDLEDSSHALLVSPCFEADAKILDAL-------EAVDLKLKVLN 657
                ..|.....:|..:.|     |||.|..|    |...:.::..:       .|.:|....|:
Human   399 ----ENEHHGPSMPALIAP-----EDSPHCDL----FPGASYLMTQIPGTQTESRAEELSPAALS 450

  Fly   658 P-LNDVTTADGERELLLAANDDFEQRILPNSSFVYQAANKQYSNNQILLNQAVNVTLVNAIEGEQ 721
            | |..:..:.....||             .|....::.:|:...|                    
Human   451 PSLEPIRCSHQPISLL-------------GSFLTEESPDKEIDQN-------------------- 482

  Fly   722 MIMEQKQLMKVRDLELTERDIDQPLKRAEKSPEKDDTLEPESLYE--PITPVMDETKTEAQTSSL 784
               .|::..::|...::.:..:.....|..:|.:.....|.|..|  ||||        |..|:.
Human   483 ---SQQEESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITP--------ASVSAR 536

  Fly   785 FKIYTKKSELVEDIYQTVEEASTVEVKPNNWLEGYESIAGSQEACPLTYDGYESFAPEEVVTTPT 849
            ..:...:.|  ........|.::..:..::     .|..|:.|.||....|:.|..     |:|.
Human   537 PPVAFPRRE--TSCAARAPETASAPLSMDD-----PSPCGTSEMCPAALYGFPSTG-----TSPP 589

  Fly   850 TPSA--TGTL---------GRNTRDELPELPKPKRVLNKSPIPLRPAPPKPQAKESEEDENIYDT 903
            .|.|  |||:         |.:..::.|:|.......:.|.:|.|  ||||.         ||.:
Human   590 RPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQR--PPKPA---------IYSS 643

  Fly   904 IKGCYESMHCKATSSSSSGEATLTTDTISLSSNCYESISHIRRSRVATTQNQGHGSAGSCIQLSS 968
            :....:....:..|:.|:....|:|    |..:..||||::.|.                   ||
Human   644 VTPRRDRRSGRDYSTVSASPTALST----LKQDSQESISNLERP-------------------SS 685

  Fly   969 SGSTLTISSDHKTNSLYESSLAAAGCVVYGSASVGCRSSLGSSAGSRDSGKPGDKRSSIAGSSDN 1033
            ..|.....|.|......||.       .|||                                  
Human   686 PPSIQPWVSPHNPAFATESP-------AYGS---------------------------------- 709

  Fly  1034 SDAWVDISDGEIGQATTDATANEAQFIVVRERFKPHRTRSPDWSKRIRDKRLQQKKAISCIEDDS 1098
            |.::|.:.|..|                       |....|...:| ||..      .|.:|.|.
Human   710 SPSFVSMEDVRI-----------------------HEPLPPPPPQR-RDTH------PSVVETDG 744

  Fly  1099 DHYYETLSPLGNKRHSTQLVRQSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSFETD 1163
             |....:..|....|...|...|       |:.:.|:.....::......:|..:..     ..|
Human   745 -HARVVVPTLKQHSHPPPLALGS-------GLHAPHKGPLPQASDPAVARQHRPLPS-----TPD 796

  Fly  1164 SDDHGDGEPDLRQRNYNDSGVDMRNHRLP------------------------KPP--PPQNQVY 1202
            |..|....|..|.........|:....||                        :||  ||:::  
Human   797 SSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSR-- 859

  Fly  1203 EFVRKFKDFISSKKSPKGSQQKLYENTPASTLFYVECSKRTEDVYENTDFGPERIPAPETKGPVH 1267
                      ...:|.:|.    :.|:.........|...|             :|.|.:.|   
Human   860 ----------GRSRSTRGG----HMNSGGHAKTRPACQDWT-------------VPLPASAG--- 894

  Fly  1268 QEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHG 1332
            :...|...|:.....:..||.:..:......:...:.|.|            |.|..|..||:.|
Human   895 RTSWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCP------------SSPTTPWTPELQG 947

  Fly  1333 SGELD-SGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPL- 1395
            ....| :|.|:.     ||.|            |:...||||    |......|     .:||: 
Human   948 PTSKDEAGVSEH-----PEAP------------AREPLRRTT----PQQGASGP-----GRSPVG 986

  Fly  1396 ---DPER--ELDAEQTTSWYAECGVFKQATNGAVSPRGD---EPVTPTPSG--HGGVSSWYAESG 1450
               .||:  .|..|:.:||        .....:..|.||   :.|.|:...  |.|    ::..|
Human   987 QARQPEKPSHLHLEKASSW--------PHRRDSGRPPGDSSGQAVAPSEGANKHKG----WSRQG 1039

  Fly  1451 LYQTSGISVASSSGSSGVSTGNEAGLGDEL---SSEPHSLF------------SNEPLYQMYSAA 1500
            |.:.| |....||.|.|.:.....|..|.:   ..:|..:.            |::.|||.||..
Human  1040 LRRPS-ILPEGSSDSRGPAVEKHPGPSDTVVFREKKPKEVMGGFSRRCSKLINSSQLLYQEYSDV 1103

  Fly  1501 KLESITRDLEAHGSSDGYEEI-GLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSC 1564
            .|   .:::::....:...|. |..:..:|...:....:.||.:...:  |.:||.|||.|.:|.
Human  1104 VL---NKEIQSQQRLESLSETPGPSSPRQPRKALVSSESYLQRLSMAS--SGSLWQEIPVVRNST 1163

  Fly  1565 ILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSV---LSAKDRKALFSYIV 1626
            :|.::|..::.|||.|||:|.||||||:|||:...||.     |.:|:   ||.::.:.|||.:.
Human  1164 VLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQ-----LSTSLRATLSNQEHQWLFSRLQ 1223

  Fly  1627 PVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESL 1691
            .|.:.|...|::||..:::||....:...:...|.....||:.:..:|...:||.:.|..|..: 
Human  1224 DVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSN- 1287

  Fly  1692 AFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQK 1756
             |::.||:||:.|.|..|:|.|||:||.||||||.||:..:..:..|.:.||.|:.|...|| ::
Human  1288 -FREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHAL-EQ 1350

  Fly  1757 VVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGE 1821
            ::..||.......:..||..:::::||...:..|.          ::.|:|||.||||.|.:   
Human  1351 LIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLI----------SQSRWLVKSGELTALEF--- 1402

  Fly  1822 DAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLK-D 1885
            .|.....::|....::..||:|.|||.:.|..|.|.|||:.|.|.:   .|:..      ::| .
Human  1403 SASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSI---RGEKC------EMKLH 1458

  Fly  1886 QAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHS 1950
            ...|||..:.|.:|......|.:....:.|::.||:.|:..|..|.   .|.|.::.|||....:
Human  1459 GPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMPREEL---DLLECYNSPQVQCLRA 1520

  Fly  1951 YESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEELNSAHVRARNLKQRHRL 2015
            |:..|.|.|.||..|||.|:::..|||.:|.|:.||..||||....|.:::..|||:|||:.||:
Human  1521 YKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVEFISNPEVRAQNLKEAHRV 1585

  Fly  2016 LTFTATYLESQ 2026
            .|.....:|.|
Human  1586 KTAKLQLVEQQ 1596

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 66/184 (36%)
PH_ephexin 1805..1931 CDD:269929 38/126 (30%)
SH3_ephexin1_like 1944..1998 CDD:212727 23/53 (43%)
ARHGEF5NP_005426.2 ARHGEF5_35 1..478 CDD:292081 115/559 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 138..246 26/121 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 258..455 54/258 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..1072 154/848 (18%)
RhoGEF 1178..1356 CDD:279015 66/185 (36%)
PH_ephexin 1378..1504 CDD:269929 39/147 (27%)
PH 1391..1497 CDD:278594 35/117 (30%)
SH3_ARHGEF5_19 1514..1568 CDD:212873 23/53 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 117 1.000 Domainoid score I5908
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41472
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12845
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.910

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