DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and fgd4b

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_001332264.7	Gene:	fgd4b / 793364	ZFINID:	ZDB-GENE-110421-6	Length:	775	Species:	Danio rerio

Alignment Length:	660	Identity:	124/660 - (18%)
Similarity:	236/660 - (35%)	Gaps:	195/660 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1363 KEAKANRRRTTIGLRPNDPPPP---------PPPMT------GNKSPLDPERE-LDAEQTTSWYA 1411
            |:|.:..|::.:......|||.         ||.::      |.::..|..|| ..::|:.|  :
Zfish    69 KDASSVLRKSAVYSVSAMPPPAVLPKPKFQCPPKISAANVIDGEQTDNDKTRERTTSDQSAS--S 131

  Fly  1412 ECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAES--GLYQTSGISVASSSGSSGVSTGNEA 1474
            ||.    |::.:.|.:.        ||....|.|::|.  |..:.||             .||.|
Zfish   132 ECA----ASSFSASDQS--------SGWDVWSGWWSEEVRGQQEESG-------------RGNGA 171

  Fly  1475 GLGDELSSEPHSLFSNEPLYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTA 1539
            .:..|               :..|..|.:.:..|:|
Zfish   172 SVEKE---------------EEQSRWKQDGLNEDME----------------------------- 192

  Fly  1540 LQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHF--- 1601
                ..::.||.....:..|.::...|..::|          |::.:|.:|:..|:||.:.|
Zfish   193 ----NDEDKPSVENDEDQQEQVNKLKLFKISS----------ELLQTERAYVSRLHLLDQVFCVR 243

  Fly  1602 MNHNAFLDSSVLSAKDRKALFSYIVPVHEC-SERLLTELE---ACWQDNIMLLGLSRCIYEIAER 1662
            :...|...|..:...  |.:||.:..::.. |:.||.:||   :.| |:...:|      ::..:
Zfish   244 LTEEALKGSFPVDVV--KGIFSNVGSIYTFHSQFLLPDLETRMSQW-DSKPRVG------DVLAQ 299

  Fly  1663 HFHVYVAFCEHQGRMDRTLRRLKESKE-SLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLP 1726
            .......:.|:....|..:..||...| |..|...::.:::...|..|.|...::.|:||:.|..
Zfish   300 LAPFLRMYAEYVKNFDSAMELLKLWMERSTQFSAIIQDIQSQEVCGSLTLQHHMLEPVQRVPRYE 364

  Fly  1727 LLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALA 1791
            :|:.. :.|:.|.:.|:....:.:|.::.......|.|..:.|...:|..|...|.....:
Zfish   365 MLLKD-YLKKLPEDDEDRSQAQKSLNIISMAATHSNMAIRKMENLKKLMEIYEMLGGEEDI---- 424

  Fly  1792 IAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCF 1856
            :.|         ...|:|.|::..|.          .:..:.:..|.|||:::||.|..:    |
Zfish   425 VNP---------SNELIKEGQILKLA----------ARNTSSMERYLFLFNNMLLYCVPK----F 466

  Fly  1857 SVFD--YCPRSMLTLAAGDSLPQLPTKDLKDQ------AGKNLILMTLLENCDRKTVELVLSCPS 1913
            |:..  :..|:.:.:   :.:..|.|.: :|.      :||            .:|:||..|  |
Zfish   467 SLVGQRFTVRTRVRV---EGMKVLETSN-EDYPHTFQVSGK------------ERTLELQAS--S 513

  Fly  1914 VSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWY 1978
            ..|::.|::|.         ::..|.:.......|.:.:....:|.:.|||       |....|
Zfish   514 QQDKEDWIKAF---------QETIEIFQQKNETFKSACKEATDEVSKEELG-------KRAPRW- 561

  Fly  1979 QGERIRDGAV 1988
                |||..|
Zfish   562 ----IRDNEV 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	39/189 (21%)
		PH_ephexin	1805..1931	CDD:269929	27/133 (20%)
		SH3_ephexin1_like	1944..1998	CDD:212727	11/45 (24%)
fgd4b	XP_001332264.7	RhoGEF	221..399	CDD:214619	39/187 (21%)
		PH1_FDG4	431..524	CDD:275434	26/124 (21%)
		FYVE_FGD1_2_4	559..623	CDD:277280	5/14 (36%)
		PH2_FGD1-4	645..748	CDD:270056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810