DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and Arhgef11

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_006232821.1	Gene:	Arhgef11 / 78966	RGDID:	619705	Length:	1577	Species:	Rattus norvegicus

Alignment Length:	1302	Identity:	264/1302 - (20%)
Similarity:	435/1302 - (33%)	Gaps:	376/1302 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   912 HCKATSSSSSGEATLTTDTISLSSNCYESISHIRRSRVATTQNQGHGSA--------GSCIQLSS 968
            |.:..|.:|...|.|....:.:..:.:.....:...|:...|:...|.|        |..| :..
  Rat    46 HHRQPSDTSETTAGLVQRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRI-IKV 109

  Fly   969 SGSTLTISSDHKTNSLYESSLAAAGCVVYGSASVGCRSSLGSSAGSRDSGKPGDKR--------- 1024
            :|:.:|.||..:...|.:|. |.|...:.||:.    .|:|.|...::....|..|
  Rat   110 NGTMVTNSSHLEVVKLIKSG-AYAALTLLGSSP----PSVGVSGLQQNPSVAGVPRVNPIIPPPP 169

  Fly  1025 --------SSIAGSSDNSDAWVDISDGEIGQATTDATANEAQFIVVRERFKPHR------TRSP- 1074
                    ..|.|..       .:.|.|:.:..|....|     ::|:..|..:      :|:|
  Rat   170 PPPPLPPPQHITGPK-------PLQDPEVQKHATQILRN-----MLRQEEKELQRIYEVYSRNPA 222

  Fly  1075 -------DWSKRIRDKRLQQKKAISCIEDDSDHYYETLSPLGNKRHSTQLVRQSQDGNRS-GGVR 1131
                   :.::| |..:||.|     |:.::....:.|.|.|.....|...|.|.|...: .|:.
  Rat   223 SLLEEQMEGARR-RVTQLQLK-----IQQETGGLVDILPPCGETSQRTCEGRLSVDSQEADSGLD 281

  Fly  1132 SSHRRSKNHSASAHTLGEHVVISD-DYDSFETD-------SDDHGDGEPDLRQRNYNDSGVDMRN 1188
            |...|..  |.|...:..:.|:|| ..||.:|.       :..|.....|......|..|:|
  Rat   282 SGTERFP--SISESLMNRNSVLSDPGLDSPQTSPVILARVAQHHRRQGSDAALLPLNHQGID--- 341

  Fly  1189 HRLPKP----------PPPQNQVYEFVRKFKDFISSKKSPKGSQQKLY----------ENTPAST 1233
             :.|||          |...|...:.:  |:|....|..|      .|          :..|...
  Rat   342 -QSPKPLIIGPEEDYDPGYFNNESDII--FQDLEKLKSHP------AYLVVFLRYIFSQADPGPL 397

  Fly  1234 LFYVECSKRTEDVYENTD------------------FGPERIPAPE------------TKGPVH- 1267
            |||: ||    :||:.|:                  ..|.|:..||            .:.|.:
  Rat   398 LFYL-CS----EVYQQTNPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDLRLRNNEDPRNV 457

  Fly  1268 ------------QEQAPVLRAKQK---------------NGKSLRSRLRKSLVGSSFDTKQLSSL 1305
                        |||....|:|:.               :|..||.|        ....|||::|
  Rat   458 LCEAQEAVMLEIQEQINDYRSKRTLGLGSLYGENDLLGLDGDPLRER--------QMAEKQLAAL 514

  Fly  1306 APTRSTFYVEDPEGSLPALPLEPEI-----HGSGELDSGFSDKNCTP---------------LPE 1350
            ....|. |.||     .:.|::..:     |....|..  |..:||.               .|:
  Rat   515 GDILSK-YEED-----RSAPMDFAVNTFMSHAGIRLRE--SRSSCTAEKTQSAPDKDKWLPFFPK 571

  Fly  1351 TPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGV 1415
            |.|.|:.::| :|:|..:::|..| ||....|......|.: .||
  Rat   572 TKKQSSNSKK-EKDALEDKKRNPI-LRYIGKPKSSSQSTFH-IPL-------------------- 613

  Fly  1416 FKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGN--EAGLGD 1478
                          .||...|.....:...:..|..|.      ....|:..:|||:  |..|..
  Rat   614 --------------SPVEVKPGNVRNIIQHFENSHQYD------VPEPGTQRLSTGSFPEDLLES 658

  Fly  1479 ELSSEPHSLFSNEPL---YQMYSAAKLESITR-----DLEA--------HGSSDGYEEIGLQAKA 1527
            :.|.....|..:|.|   .:|..:.|.|::.|     |::|        ..:|.....:..::..
  Rat   659 DSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEAARLHQSASSSASSLSTRSLE 723

  Fly  1528 KPEPLVKPRPTALQLVEPKNG------------------------PSRTLWSEIPEVIHSCILPT 1568
            .|.|...|:.....:..|..|                        |....|.   ..:...::..
  Rat   724 NPTPPFTPKMGRRSIESPNLGFCTDVILPHLLEDDLGQLSDLEPEPEVQNWQ---HTVGKDVVAN 785

  Fly  1569 LTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALF---SYIVPVHE 1630
            ||.||...||...|:..:|||:|::|.:|...|  :......:::..::...||   ..::.:|.
  Rat   786 LTQREIDRQEVINELFVTEASHLRTLRVLDLIF--YQRMRKENLMPREELARLFPNLPELIEIHN 848

  Fly  1631 --CSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAF 1693
              |........|.....:|..|.|:|......|....|...||.:|. :...|.|.|:.||| .|
  Rat   849 SWCEAMKKLREEGPIIRDISDLMLARFDGPAREELQQVAAQFCSYQS-VALELIRTKQRKES-RF 911

  Fly  1694 QQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQ--K 1756
            |..::..|:.|.|..|.|...::..|||:|:.|||::.:. |.:.....|:|  ||..|..|  :
  Rat   912 QLFMQEAESHPQCRRLQLRDLIVSEMQRLTKYPLLLENII-KHTEGGTSEHE--KLCRARDQCRE 973

  Fly  1757 VVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAG------AKPRFLVKRGELTH 1815
            ::...|||..:.|....||...::|:      |.|:.....|.|.      ...|.::..|.||
  Rat   974 ILKFVNEAVKQTENRHRLEGYQKRLD------ATALERASNPLAAEFKSLDLTTRKMIHEGPLT- 1031

  Fly  1816 LLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGE----SCFSVFDYCPRSMLTLAAGDSLP 1876
              ||....|        .:.:...|..||::|.:|:.|    .|.|          ..|.|.|
  Rat  1032 --WRISKDK--------TLDLQVLLLEDLVVLLQRQEERLLLKCHS----------KTAVGSS-- 1074

  Fly  1877 QLPTKDLKDQAGKNLILMTLLEN---CDRKTVELV----LSCPSV--------SDQQRWLQAMRP 1926
                 |.|......|.|..:|..   .|::...::    |..|.:        ||:..|::.:.
  Rat  1075 -----DSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSELGPPQIYELVALTSSDKNIWMELLE- 1133

  Fly  1927 PEA-----ETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVS---RKLPDGWYQGERI 1983
             ||     :.||.........|....:.:|:......:::...:|.:..   :|||:|....:|:
  Rat  1134 -EAVQNATKHPGAAPIPIHPSPPGSQEPAYQGSTSSRVEINDSEVYHTEKEPKKLPEGPGPEQRV 1197

  Fly  1984 RD 1985
            :|
  Rat  1198 QD 1199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	49/188 (26%)
		PH_ephexin	1805..1931	CDD:269929	31/149 (21%)
		SH3_ephexin1_like	1944..1998	CDD:212727	8/45 (18%)
Arhgef11	XP_006232821.1	PDZ_signaling	63..128	CDD:238492	11/65 (17%)
		DegQ	<78..154	CDD:223343	19/81 (23%)
		flgC	269..>358	CDD:139220	21/94 (22%)
		RGS_PDZRhoGEF	347..491	CDD:188707	26/156 (17%)
		RhoGEF	796..980	CDD:279015	49/190 (26%)
		PH_PRG	997..1139	CDD:275426	36/177 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810