DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and net1

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_001072884.2	Gene:	net1 / 780346	XenbaseID:	XB-GENE-487220	Length:	585	Species:	Xenopus tropicalis

Alignment Length:	538	Identity:	121/538 - (22%)
Similarity:	202/538 - (37%)	Gaps:	149/538 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1492 PLYQMYSAAKLESITRD--------------LEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQL 1542
            ||.::.|.|.|.|..|:              :.|...|.|..:......|.|.|
Frog   102 PLSRVTSLANLISPVRNGAVRRFGQTIQSFTMRAENKSPGGTQKACSKVAAPTP----------- 155

  Fly  1543 VEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAF 1607
              ||...| .||||:.::   .:..:|:::|...|||.||:...|...:..|.|.|:.:  |:..
Frog   156 --PKRRNS-VLWSEMLDI---NMKESLSTKEIKRQEAIFEMTKGEQDLIDDLKLARKAY--HDPM 212

  Fly  1608 LDSSVLSAKDRKALF----SYIVPVHECSERLLTEL-EACWQDN-------IMLLGLSRCIYEIA 1660
            |..|::|.::...:|    ||| |:|   |.||.:| ||...|.       |::..|.|
Frog   213 LKLSIMSEEELTQIFGDLDSYI-PLH---EELLAKLGEATKADGTVGQIGPILINWLPR------ 267

  Fly  1661 ERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRL 1725
               .:.|..:|.:|......|.:.|..:.   .|..|:|...||....|:|.|||.:|..|:.:.
Frog   268 ---LNAYKEYCSNQLAAKALLDKKKLDRR---VQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKY 326

  Fly  1726 PLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERI------ARQLEFP 1784
            |||:..:. :.:|.:..:.:.....|.|:|.|:...|......|..:.::::      .:.|...
Frog   327 PLLLKEIL-RHTPKDHPDTKGLHEALCLIQGVLTDINLKKGESECQYYIDKLEYLDDKQKDLRIE 390

  Fly  1785 SHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCK 1849
            |                  .:.|:..|||               |......::.|||.|:|:|.:
Frog   391 S------------------SKALLCHGEL---------------KNKNGHKLFLFLFQDVLVLTR 422

  Fly  1850 ---RRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKD---QAGKNLILMTLLENCDR-KTVEL 1907
               |.....|.|:    |..:      .:..|..:||:|   :.|.:  ......|.|: |.:..
Frog   423 PVIRNEHQHFQVY----RQPI------PVQDLVLEDLQDGDVRMGGS--FRGAFSNSDKAKNIFR 475

  Fly  1908 V------------LSCPSVSDQQRWLQ----AMRPPEAETPGEK-----LYESWDC-----PQVV 1946
            |            |....|..:|:||.    |:.|.:..:|.|:     |.|  :|     |...
Frog   476 VRFKDAGAGQSHTLQANDVFHKQQWLNCIKTAVSPYQQASPTEQKELPDLNE--ECEENNPPATN 538

  Fly  1947 AK-HSYESDEPDVLQLEL 1963
            :| |...|....:::::|
Frog   539 SKDHRRSSTISGIMEMDL 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	51/193 (26%)
		PH_ephexin	1805..1931	CDD:269929	31/148 (21%)
		SH3_ephexin1_like	1944..1998	CDD:212727	4/21 (19%)
net1	NP_001072884.2	RhoGEF	186..362	CDD:366202	52/194 (27%)
net1	NP_001072884.2	PH_Net1	376..510	CDD:270044	32/178 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940