DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and Arhgef12

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_081420.2	Gene:	Arhgef12 / 69632	MGIID:	1916882	Length:	1544	Species:	Mus musculus

Alignment Length:	1356	Identity:	263/1356 - (19%)
Similarity:	458/1356 - (33%)	Gaps:	412/1356 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   854 TGTLGRNTRDELPELPKPKR---VLNKSPIPLRPAPPKPQAKESEEDENIYDTIKGCYESMHCKA 915
            :||....| |..| |.||.|   :||      |.:|...:.|......:.:|            .
Mouse     2 SGTQSTIT-DRFP-LKKPIRHGSILN------RESPTDKKQKVERSSSHDFD------------P 46

  Fly   916 TSSSSSGEATLTTDTISLSSNCYESISHIRRSRVATTQNQGHGSAGSC--IQLSSSGSTLTISSD 978
            |.|||.          ...|:..||.|.|            :|....|  ||...:|..||:|.|
Mouse    47 TDSSSK----------KTKSSSEESRSEI------------YGLVQRCVIIQKDDNGFGLTVSGD 89

  Fly   979 HKTNSLYESSLAAAGCVVYGSASVGCR------------------------SSLGSSAGSRDSGK 1019
               |.::..|:...|..:......|.|                        |.:..:...|..|.
Mouse    90 ---NPVFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIRSGSYVALTVQGRPPGS 151

  Fly  1020 P------GDKRSSIAG------SSDNSDAWVDISDGEIGQATTDATANEAQFIVVRERFKPHRTR 1072
            |      .:...|:.|      :|.:|..    :.|.:.:.|:.....|...:|..::.:
Mouse   152 PQIPLADSEVEPSVTGHMSPIMTSPHSPG----AAGNMERITSPVLVGEENNVVHNQKVE----- 207

  Fly  1073 SPDWSKRIRDKRLQ-QKKAISCIEDDSDHYYET-----LSPLGN-KRHSTQLVRQ-------SQD 1123
                   |..|.|| :::.:..:::|   |..|     |..:.. |:|..||..|       :||
Mouse   208 -------ILRKMLQKEQERLQLLQED---YNRTATQRLLKEIQEAKKHIPQLQEQLSKATGSAQD 262

  Fly  1124 GNRSGGVRSSHRRSKNHSASAHTLGEHVVISD------------DY---DSFETDSDDHGDGEPD 1173
            |              ...|.:..||:.:.:|:            |:   |:....||.....:..
Mouse   263 G--------------AVIAPSRPLGDALTLSEAEADPGDGLCRTDWSSGDASRPSSDSADSPKSS 313

  Fly  1174 LRQRNYNDSGVDMRNHRLPKPPPPQNQV-YEFVRKFKDFISSKKSPKGSQQ-------------K 1224
            ||:|:|.:...: |:..:.....||:.| ....|.....|.::....|::.             :
Mouse   314 LRERSYLEEAPE-RSEGVQDAQEPQSLVGSPSTRGAPHIIGAEDDDFGTEHEQINGQCSCFQSIE 377

  Fly  1225 LYENTPA-----------------------STLFYVECSKRTEDVY-ENTDFGPER-----IPAP 1260
            |.::.||                       |.|:....||.|..|: |...|..:|     :|.|
Mouse   378 LLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKQTNSKETRRVFLEFHQFFLDRSAHLKVPVP 442

  Fly  1261 ETKGPVHQEQAPVLRAKQKNG---KSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLP 1322
            |......:::.|.|..:..:.   ::::.|:...:.....|.:|..|:..|.:       |..|.
Mouse   443 EEISVDLEKRRPELIPEDLHRLYIQTMQERVHPEVQRHLEDFRQKRSMGLTLA-------ESELT 500

  Fly  1323 ALPLE-PEIHGSGELDSGFSDKNCTPLPET---------PKFSTV-------------------- 1357
            .|..| .:..|:.|.:...:::..|.:.|.         .:.||:
Mouse   501 KLDAERDKDRGTLEKERACAEQIVTKIEEVLMTAQAVEEERSSTMQYVILMYMKYLGVKVKEPRN 565

  Fly  1358 ----------ARKAKKEAKANRRRTTIGLRPNDPP---PPPPPMTGNKSPLDPERELDAEQTTSW 1409
                      ..|.|:..|.:|.....|.|...|.   ||..|...:.|.:....|:...:...
Mouse   566 LEHKRGRIGFLPKIKQSMKKDREGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMEIQKSRHPK- 629

  Fly  1410 YAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGNEA 1474
                   ..:|..:|||   ||..|......||::...::|....|.:    ||.:||.:...|.
Mouse   630 -------HLSTPSSVSP---EPQDPAKLRQSGVANEGTDTGYLPASSM----SSATSGTALSQEG 680

  Fly  1475 GL---------------GDELSSEPH---SLFS-NEPLYQMYSAAKLESITRDLEAHGSSDGYEE 1520
            |.               ||.|.|.|.   ::|. ..||.......:.| :.|..| ||:...:.:
Mouse   681 GRENDTGTKQVGEASAPGDCLDSTPRVPTTVFDFPPPLLDQVQEEECE-VERVAE-HGTPKPFRK 743

  Fly  1521 IGL----QAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKF 1581
            ...    :::::.|.......|     :|.|      |.::   :...:|..|...|...||...
Mouse   744 FDSIAFGESQSEDEQFENDLET-----DPPN------WQQL---VSREVLLGLKPSEIKRQEVIN 794

  Fly  1582 EIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDN 1646
            |:..:|.:::::|.:|.:.|  :.......:||..:.:.:||.:..:.:....|..:::|..:.|
Mouse   795 ELFYTERAHVRTLKVLDQVF--YQRVSREGILSPSELRKIFSNLEDILQLHVGLNEQMKAVRKRN 857

  Fly  1647 ----IMLLGLSRCIYEIA---ERHFHVYVAFCEHQGRMDRTLRRLK-ESKESLAFQQHLERLEAS 1703
                |..:|....|:...   |:..|....||.:|   ...|..:| ..|:...|...::..|::
Mouse   858 ETSVIDHIGEDLLIWFSGPGEEKLKHAAATFCSNQ---PFALEMIKSRQKKDSRFHTFVQDAESN 919

  Fly  1704 PSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQC------- 1761
            |.|..|.|...:...|||:|:.|||:|         |..:|..|......|:|....|
Mouse   920 PLCRRLQLKDIIPTQMQRLTKYPLLLD---------NIAKYTEWPPEREKVKKAADHCRQILNYV 975

  Fly  1762 NEAANRWEQAFELERIARQL--------EFPS--HVRALAIAPVGVPRAGAKPRFLVKRGELTHL 1816
            |:|....|....||...|:|        |:|:  .:|.|.:.          .|.::..|.   |
Mouse   976 NQAVREAENKQRLEDYQRRLDTSNLKLSEYPNVDELRNLDLT----------KRKMIHEGP---L 1027

  Fly  1817 LWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGE----SCFSVFDYCPRSMLTLAAGDS--- 1874
            :|:....|        .|.:|..|..|:|:|.:::.:    .|        .|.:..:..||
Mouse  1028 VWKVNRDK--------SIDLYTLLLEDILVLLQKQDDRLVLRC--------HSKILASTADSKHT 1076

  Fly  1875 ---LPQLPTKDLKDQA--GKNLILMTLLEN-----------CDRKTVELVLSC---PSVSDQQ-R 1919
               :.:|.|..::..|  .|.|.::::.:|           ...|||...|.|   .||.:|. :
Mouse  1077 FSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTK 1141

  Fly  1920 WLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPD 1975
            .:...:||..|  |:.                :.:||..|::|..|:.....:.||
Mouse  1142 PIPLPQPPPCE--GDN----------------DEEEPAKLKVEHHDLSVAGLQSPD 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	43/196 (22%)
		PH_ephexin	1805..1931	CDD:269929	31/152 (20%)
		SH3_ephexin1_like	1944..1998	CDD:212727	7/32 (22%)
Arhgef12	NP_081420.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		21/89 (24%)
		PDZ_signaling	71..145	CDD:238492	14/76 (18%)
		RGS_LARG	350..571	CDD:188708	34/227 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..711		34/150 (23%)
		RhoGEF	792..977	CDD:279015	43/198 (22%)
		PH_LARG	996..1133	CDD:275425	30/165 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1138..1159		5/38 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1387..1406
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1442..1469
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810