DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and Arhgef16

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_001121063.1	Gene:	Arhgef16 / 687105	RGDID:	1588981	Length:	709	Species:	Rattus norvegicus

Alignment Length:	746	Identity:	214/746 - (28%)
Similarity:	343/746 - (45%)	Gaps:	97/746 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1318 EGSLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDP- 1381
            :.||....||...|....||:     |..|:|..|..     :...:|:||     ....|:.|
  Rat     7 DSSLDEKLLEYRFHAELRLDA-----NGNPVPGLPMV-----RGSLKARAN-----AAFEPDAPE 56

  Fly  1382 ---PPPP------PPMTGNKSP---------LDPER-ELDAEQTTSWYAECGVFKQATNGAVSPR 1427
               ||||      |.:...:||         |.|:. .:.::..|...|....|..|.....:.|
  Rat    57 SLQPPPPGDEEPRPIILSTQSPAALKMGTQQLIPKSLAVASKAKTKSPARHQSFGAAVLSKEAAR 121

  Fly  1428 GDEPVTPTPSGH----------GGVSSWYAESGLYQTS--GISVASSSGSSGVSTGNE-AGLGDE 1479
            ....:.|.||..          ||.......:..|:.:  |:...||...| |..|.: ..|.:|
  Rat   122 RTPQLLPAPSFSLDDMDMDAVTGGNLKRNLRNQSYRAAMKGLGPPSSKEDS-VRLGPKLQALAEE 185

  Fly  1480 LSSEPHSLFSNEPL--YQMYSAAKLESITRDLEAHGSSDGYEEI---GLQAKAKPEPLVKPRPTA 1539
            .:..|    :..|.  .:.:..|...|...|.:.      |:||   ||....:.:..:...|::
  Rat   186 AAQPP----ARHPAKNKKTWKRANKGSFKDDPQL------YQEIRERGLNTSHESDDDILDEPSS 240

  Fly  1540 --------LQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNL 1596
                    ..:|.....|::..||::|||:.|.||.||:..||..|||.|||:|||.|||.||.:
  Rat   241 SGGTQRGDTTIVVKTYRPAQLTWSQLPEVLESGILDTLSVEERKRQEAIFEILTSEFSYLHSLKI 305

  Fly  1597 LRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAE 1661
            |...|:.....  .:.::..:...|||.|..|...|::....||...:..:.:..:|..:.:.||
  Rat   306 LVNEFLQSQEL--KTTMTQTEHHHLFSNISDVLAASQKFFESLEQRHKAQVCVEDISDILEDHAE 368

  Fly  1662 RHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLP 1726
            .|||.|:|:|.::....|||::|  |..:.||::.|..:|..|:|.||.:.|||:|||||:||||
  Rat   369 NHFHPYIAYCSNEVYQQRTLQKL--SNSNTAFREVLREIEKLPACGGLPMISFLILPMQRVTRLP 431

  Fly  1727 LLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALA 1791
            ||.|.:..|... :.|.|::....|..:.|:|.||||.|::.|:..::..:..||:| ..|::|.
  Rat   432 LLTDTLCLKTQG-HPERYKAASRALKAISKLVKQCNEGAHKMERTEQMYTLHMQLDF-GKVKSLP 494

  Fly  1792 IAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCF 1856
            :.        :..|:|:|||||..|    |::.: |.|..::.:.|.|||:|:|::.|::.|..:
  Rat   495 LI--------SASRWLLKRGELLLL----EESSI-FRKIASRPTCYLFLFNDVLVVTKKKSEESY 546

  Fly  1857 SVFDYCPRSMLTL--AAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQR 1919
            .|.||.....:.:  .....|| ||....:..:......:.||.|.:.:..:::||..|.||:.|
  Rat   547 LVQDYAQLDHVQVRKVEPSELP-LPGGSSRSSSVPYPFQVNLLHNSEGRQEQILLSSDSASDRAR 610

  Fly  1920 WLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIR 1984
            |:.|:...|.:..|  :....:.|||....:|.:.:.|.:.|:..|||.|.:: .|||..|||:|
  Rat   611 WITALSYKERQWQG--ISNKGELPQVEVTKAYFAKQADEITLQQADVVLVLQE-EDGWLYGERLR 672

  Fly  1985 DGAVGWFPGSYTEELNSAHVRARNLKQRHRL 2015
            ||..||||.|:...:.|......|:::..||
  Rat   673 DGETGWFPESFAHCITSRVAVEGNVRRMERL 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	66/181 (36%)
		PH_ephexin	1805..1931	CDD:269929	38/127 (30%)
		SH3_ephexin1_like	1944..1998	CDD:212727	23/53 (43%)
Arhgef16	NP_001121063.1	RhoGEF	288..466	CDD:395496	66/182 (36%)
		PH_ephexin	489..622	CDD:269929	40/146 (27%)
		SH3_ARHGEF16_26	633..684	CDD:212871	23/51 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5800
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45587
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12845
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910