DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Exn and ARHGEF28

DIOPT Version :9

Sequence 1:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster
Sequence 2:NP_001073948.2 Gene:ARHGEF28 / 64283 HGNCID:30322 Length:1731 Species:Homo sapiens


Alignment Length:1518 Identity:281/1518 - (18%)
Similarity:488/1518 - (32%) Gaps:513/1518 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   602 VTRKEDFTLDLPKEVIPRAEDLEDSSHALLVSPCFEADAKILDALEAVDLKLKVLNPLNDVTTAD 666
            ||..::....|.:.::.:|..|...||..|::| |...|..|.||                    
Human    89 VTYVDNMACRLARLLVTQANRLTACSHQTLLTP-FALTAGALPAL-------------------- 132

  Fly   667 GERELLLAAND---DFEQRILPNSSFVYQAANKQYSNNQILLNQAVNVTLVNAIEGEQMIMEQKQ 728
             :.||:||...   ..|..:|.:||.      :..|:.:.||:.|:...|..        :.|..
Human   133 -DEELVLALTHLELPLEWTVLGSSSL------EVSSHRESLLHLAMRWGLAK--------LSQFF 182

  Fly   729 LM---KVRDLELTERDIDQPLKRAEKSPEKDDTLEPESLYEPIT-------PVMDETKTEAQTSS 783
            |.   .|:.|.|...:...||..|.:...       ..|.|.:|       |.....:. ::.:|
Human   183 LCLPGGVQALALPNEEGATPLDLALREGH-------SKLVEDVTNFQGRWSPSFSRVQL-SEEAS 239

  Fly   784 LFKIYTKKSELVEDIYQTVEEASTVEVK---PNNWLEGYESIAGSQEACPLTYDGYESFAPEEVV 845
            |..|::.:: |...:..|.|.....::|   ...|...:...|...||           .|||..
Human   240 LHYIHSSET-LTLTLNHTAEHLLEADIKLFRKYFWDRAFLVKAFEPEA-----------RPEERT 292

  Fly   846 TTPTTPSATGTLGRNTRDELPELPKPKRVLNKSPIPLRPAPPKPQAK----------ESEEDENI 900
            ..|::       |..|.:|:           |:.:..|.|..|...|          |.|:..::
Human   293 AMPSS-------GAETEEEI-----------KNSVSSRSAAEKEDIKRVKSLVVQHNEHEDQHSL 339

  Fly   901 -----YDTIKGCYESMHCKATSSSSSGEATLTTDTISLSSNCYESISHIRRSRVATTQNQGHGSA 960
                 :|.:|             .|...:||                 :...|::...|.|....
Human   340 DLDRSFDILK-------------KSKPPSTL-----------------LAAGRLSDMLNGGDEVY 374

  Fly   961 GSCIQLSSSGSTLTISSDHKTNSLYESSLAAAGCVVYGSASVGCRSSLGSSAGSRDSGKPGDKRS 1025
            .:|:.:...|. |.||..:.......:|..:.||.::..:|   :.:|           |.:...
Human   375 ANCMVIDQVGD-LDISYINIEGITATTSPESRGCTLWPQSS---KHTL-----------PTETSP 424

  Fly  1026 SIAGSSDNSDAWVDISDGEIGQATTDATANEAQFIVVRERFKPHRTRSPDWSKRIRDKRLQQKKA 1090
            |:...|:|.:          |.|.|:|   :..|:........:...|..|..            
Human   425 SVYPLSENVE----------GTAHTEA---QQSFMSPSSSCASNLNLSFGWHG------------ 464

  Fly  1091 ISCIEDDSDHYYETLSPLGNKRHSTQLVRQSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISD 1155
               .|.:..|.         |:.|:.|.....|....|....||......|.|:...|  :...|
Human   465 ---FEKEQSHL---------KKRSSSLDALDADSEGEGHSEPSHICYTPGSQSSSRTG--IPSGD 515

  Fly  1156 DYDSFETDSDDHGDGEPD------------------------LRQRNYN---------------- 1180
            :.|||||::      |||                        :|.|:|:                
Human   516 ELDSFETNT------EPDFNISRAESLPLSSNLQSKESLLSGVRSRSYSCSSPKISLGKTRLVRE 574

  Fly  1181 ----DSGVDMRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKLYENTPASTLFYVECSK 1241
                .|..:.|.:.|.: ||.:|::.|  .::..:|    .|..|:.:.|:              
Human   575 LTVCSSSEEQRAYSLSE-PPRENRIQE--EEWDKYI----IPAKSESEKYK-------------- 618

  Fly  1242 RTEDVYENTDFGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLS--S 1304
                |.....|...|:.:|..|.          :.|.|:.|               |.::|:  .
Human   619 ----VSRTFSFLMNRMTSPRNKS----------KTKSKDAK---------------DKEKLNRHQ 654

  Fly  1305 LAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCTP-LPETPKFSTVARKAKKEAKAN 1368
            .||  .||     .|.|..|..:..:.|...|..    .||.. :.:..|.:..|...|.:.|.|
Human   655 FAP--GTF-----SGVLQCLVCDKTLLGKESLQC----SNCNANVHKGCKDAAPACTKKFQEKYN 708

  Fly  1369 RRRTTIGLRPNDPPPPPPPMTGNKSPLD-PERELDAEQTTSWYAECGVFKQATNGAVSPRG-DEP 1431
            :.:             |..:.||.|..| |:..|....::|........::.|.|.|.|.. ..|
Human   709 KNK-------------PQTILGNSSFRDIPQPGLSLHPSSSVPVGLPTGRRETVGQVHPLSRSVP 760

  Fly  1432 VTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEPLYQM 1496
            .|...|              ::.|..|:.|.|              |..|....| .|:|.|..|
Human   761 GTTLES--------------FRRSATSLESES--------------DHNSCRSRS-HSDELLQSM 796

  Fly  1497 YSAAKLES------ITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWS 1555
            .|:...||      :...|.:..|||..|   .:|::                          ||
Human   797 GSSPSTESFIMEDVVDSSLWSDLSSDAQE---FEAES--------------------------WS 832

  Fly  1556 EIPEVIHSCILPTLTSRER----SLQEAKFEIITSEASYLKSLNLLRRHF---MNHNAFLDSSVL 1613
            .:.:       |:..:|:.    ..|:..||::.:|..::::|.::...|   |.....||.|.:
Human   833 LVVD-------PSFCNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTV 890

  Fly  1614 SAKDRKALFSYIVPVHECSERLL------------TELEACWQ-------DNIMLLGLSRCIYEI 1659
            .            .:..|.:.||            ...|:|..       |.|..:.:.:...|.
Human   891 D------------KIFPCLDELLEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEEN 943

  Fly  1660 AERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQH--------LERLEASPSCCGLNLHSFLM 1716
            |.:...:|..||.|........:.|:::|:   ||..        |.|....|.|        ::
Human   944 ASKMKKIYGEFCCHHKEAVNLFKELQQNKK---FQNFIKLRNSNLLARRRGIPEC--------IL 997

  Fly  1717 LPMQRITRLPLLIDAV--FSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIAR 1779
            |..||||:.|:|::.:  ::||   ..||::..:..|.|::.::...:...|.:|:..:...|..
Human   998 LVTQRITKYPVLVERILQYTKE---RTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILN 1059

  Fly  1780 QLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTK--ISIYAFLFS 1842
            ::|..::.:.         :.|...|......|...||:.|    |.:.|..|.  ..|.|.|.:
Human  1060 KIENKTYTKL---------KNGHVFRKQALMSEERTLLYDG----LVYWKTATGRFKDILALLLT 1111

  Fly  1843 DLLLLCKRRGES-CFSVFDYCP-----------------RSMLTLAAGDSLPQLPTKDLKDQAGK 1889
            |:||..:.:.:. .|:..|..|                 |.|..::|..:.|::.......:..:
Human  1112 DVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHTNSKEER 1176

  Fly  1890 NLILMTLLENCDRKTVELVLSCP-------SVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVA 1947
            |        |..|:..:.|.|||       |.||:.:     |..||     ::.:...|.:::.
Human  1177 N--------NWMRRIQQAVESCPEEKGGRTSESDEDK-----RKAEA-----RVAKIQQCQEILT 1223

  Fly  1948 KHSYE----SDEPDVLQLELGDV 1966
            ....:    .:|...:..|||::
Human  1224 NQDQQICAYLEEKLHIYAELGEL 1246

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 43/213 (20%)
PH_ephexin 1805..1931 CDD:269929 34/152 (22%)
SH3_ephexin1_like 1944..1998 CDD:212727 4/27 (15%)
ARHGEF28NP_001073948.2 ANK <153..216 CDD:295348 16/83 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..316 10/46 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 473..524 16/52 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 630..649 6/43 (14%)
C1 653..698 CDD:237996 12/55 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 710..800 27/131 (21%)
RhoGEF 853..1042 CDD:214619 43/214 (20%)
PH_p190RhoGEF 1087..1187 CDD:275430 22/111 (20%)
PH <1123..1188 CDD:278594 10/72 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1187..1207 7/24 (29%)
Interaction with PTK2/FAK1, required for regulation of axonal branching and synapse formation. /evidence=ECO:0000250 1295..1304
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1312..1339
Mediates cytoplasmic retention and interaction with YWHAH. /evidence=ECO:0000250 1372..1383
RNA-binding. /evidence=ECO:0000250 1496..1527
Mediates cytoplasmic retention and interaction with MAPK8IP1. /evidence=ECO:0000250 1566..1579
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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