DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and Arhgef26

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_001074764.1	Gene:	Arhgef26 / 622434	MGIID:	1918053	Length:	869	Species:	Mus musculus

Alignment Length:	984	Identity:	266/984 - (27%)
Similarity:	404/984 - (41%)	Gaps:	233/984 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1098 SDHYYETLSPLGNKRHSTQLVRQSQDG--NRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSF 1160
            :|...|.|:.|...:...::.....|.  :||..:.|:|||...:.
Mouse    48 TDFPVEELAALPTPQTPVRVPADPDDRTVSRSPQLLSAHRRPVTNG------------------- 93

  Fly  1161 ETDSDDHGDGEPDLRQRNYNDSGVDMRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKL 1225
            .|.|.|:....|.||:               ||.|            ...:.:|..|||.:.
Mouse    94 RTVSPDYRAASPRLRR---------------PKSP------------LVSYAASGGSPKSTS--- 128

  Fly  1226 YENTPASTLFYVECSKRTEDV-------YENTDFGPERIPAPETKGPVHQ--EQAPVLRAKQKNG 1281
             ..|.||....:..:.||.|.       .:.|.....::.:|...|..|:  ...||.:..|..|
Mouse   129 -NGTVASPAALLSRASRTPDTPASCATDEDCTGVTASKVSSPIANGLAHKTDSSGPVSQTGQPAG 192

  Fly  1282 KSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCT 1346
            .                    ..|||:|.:          ||||     |.|.|        ...
Mouse   193 D--------------------LELAPSRLS----------PALP-----HKSSE--------QKL 214

  Fly  1347 PLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPP--------PPPMTGNKSPLDPE---RE 1400
            ||...|.                       :.|:.|.|        |..:...|..:.|:   .|
Mouse   215 PLQRLPS-----------------------QGNELPNPSVVLSTNSPAALKMGKQQIIPKSLASE 256

  Fly  1401 LDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVAS-SSG 1464
            :...::.|...|...........|...|      .|.||.|      |.|.......|..| ..|
Mouse   257 IKLSKSNSQNVESHRRLLKVRSMVEGLG------APLGHEG------EEGEVDNDMDSPGSLRRG 309

  Fly  1465 SSGVSTGNEAGLGDELSSEPHSLFSN---EPLYQ--MYSAAKLESITR----DLEAHGSSDG--- 1517
            ....|.......|.:..|...|...|   :|:.:  |....|..|:.|    .|:..|:.||
Mouse   310 LRSTSYRRAVVSGFDFDSPTSSKKKNRMSQPVLKAVMEDKEKFSSLGRIKKKILKGQGTFDGEEN 374

  Fly  1518 ------YEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSL 1576
                  |:|..|...:..||..|.:....::| ..:.|.|:.||::..|..:.:..|::..||..
Mouse   375 AVLYQNYKEKALDIDSDEEPEAKEQKAEERIV-IHHKPLRSTWSQLSAVKRNGLSQTVSQEERKR 438

  Fly  1577 QEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEA 1641
            |||.||:|:||.|||.||.:|.|.|.|.....|:  ::..:|..|||.|..|.|.|::..|||||
Mouse   439 QEAIFEVISSEHSYLLSLEILIRMFKNSKELTDT--MTKTERHHLFSNITDVWEASKKFFTELEA 501

  Fly  1642 CWQDNIMLLGLSRCIYEIAERH----FHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEA 1702
            ..|:||.:..:|    :|.|:|    |..||.:|.::....|||::|..:..|  |::.|.|:|:
Mouse   502 RHQNNIFIEDIS----DIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPS--FKEVLSRIES 560

  Fly  1703 SPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANR 1767
            ...|..|.:.|||:|||||:||||||:|.:..| :|.:..:||..|..|..|.|:|..|||.|.:
Mouse   561 HEDCRNLPMISFLILPMQRVTRLPLLMDTICQK-TPKDSPKYEVCKRALKEVSKLVRLCNEGARK 624

  Fly  1768 WEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLT 1832
            .|:...:..|..||||       .|.|..:.   :..|:||||||||..:   ||..| |.||::
Mouse   625 MERTEMMYTINSQLEF-------KIKPFPLV---SSSRWLVKRGELTAYV---EDTVL-FSKRMS 675

  Fly  1833 KISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKN------- 1890
            |..:|.|||:|:|::.|::.|..::|.||..|..|.:.:.|:      ::|....|||
Mouse   676 KQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDN------EELNSSPGKNPSTMLYS 734

  Fly  1891 -------LILMTLLENCDRKTVELVLSCPSVSDQQRWLQAM------RPPEAETPGEKLYESWDC 1942
                   |..:|:|.|...:.|:::|...:.|::.||:.|:      :||:..|          .
Mouse   735 RQSSATHLFTLTVLSNHASEKVDMLLGAETQSERARWITALGHSSGKQPPDRTT----------L 789

  Fly  1943 PQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEELNSAHVRAR 2007
            .||....|:.:.:||.|.|::.|||.:.:::.||||:|||:|||..||||....:|:.......:
Mouse   790 TQVEIIRSFTAKQPDELSLQVADVVLIYQRVGDGWYEGERLRDGERGWFPMECAKEITCQATIDK 854

  Fly  2008 NLKQRHRLL 2016
            |:::..|||
Mouse   855 NVERMGRLL 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	75/185 (41%)
		PH_ephexin	1805..1931	CDD:269929	46/145 (32%)
		SH3_ephexin1_like	1944..1998	CDD:212727	24/53 (45%)
Arhgef26	NP_001074764.1	RhoGEF	441..620	CDD:279015	76/187 (41%)
		PH_ephexin	641..779	CDD:269929	46/150 (31%)
		SH3_ARHGEF16_26	791..845	CDD:212871	24/53 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5824
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43520
orthoMCL	1	0.900	-	-		OOG6_105893
Panther	1	1.100	-	-	O	PTHR12845
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.840