Protein Alignment Exn and PLEKHG5

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_001252522.1
• Gene: PLEKHG5 / 57449
• HGNCID: 29105
• Length: 1075
• Species: Homo sapiens
• Alignment Length: 965
• Identity: 200/965 - (20%)
• Similarity: 335/965 - (34%)
• Gaps: 270/965 - (27%)

  Fly  1068 PHRTRSPDWS-KRIRD-----------KRLQQKKAISCIEDDSDHYYETLSPLGNKRHSTQLVRQ 1120
            |.|...|.|: .|.||           ::|.::..::..|.....::.|:...|:.|.  .|..|
Human    21 PLRDSEPSWAGGRARDGDSQVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRF--DLPPQ 83

  Fly  1121 SQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSFETDSDDHGDGEPDLRQRNYNDSGVD 1185
            .....|:...||...|:                |...|..|.:.:...||:.|.:.....
Human    84 GSVLARNVSTRSCPPRT----------------SPAVDLEEEEEESSVDGKGDRKSTGLK----- 127

  Fly  1186 MRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKLYENTPASTLFYVECSKRTEDVYENT 1250
                                      :|.||:     ::.:.:.|:.     ||.....|:  |.
Human   128 --------------------------LSKKKA-----RRRHTDDPSK-----ECFTLKFDL--NV 154

  Fly  1251 DFGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVE 1315
            |...|.:||.:.|. :.:...||..             ||.:.....|.....|..|...||...
Human   155 DIETEIVPAMKKKS-LGEVLLPVFE-------------RKGIALGKVDIYLDQSNTPLSLTFEAY 205

  Fly  1316 DPEG-----SLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIG 1375
            ...|     ..||.|.:     .|:::.|..|.....||......| ...|.:...|..||.::.
Human   206 RFGGHYLRVKAPAKPGD-----EGKVEQGMKDSKSLSLPILRPAGT-GPPALERVDAQSRRESLD 264

  Fly  1376 LRPNDPPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPT----P 1436
            :                  |.|.|.   .:..|.:.          |..|..|.||.||:    |
Human   265 I------------------LAPGRR---RKNMSEFL----------GEASIPGQEPPTPSSCSLP 298

  Fly  1437 SGHGGVS----SWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEPLYQMY 1497
            ||..|.:    ||...:    .|..|...|||.|..:.|.|....::|..:.|:          |
Human   299 SGSSGSTNTGDSWKNRA----ASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHT----------Y 349

  Fly  1498 SAAKLESITRDLE-AHGS-SDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEV 1560
            |...|..:.|.|. .|.| .:.|:|...:..|           .|:|.:.        |.|:.:.
Human   350 SLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNA-----------CLRLEDS--------WRELIDG 395

  Fly  1561 IHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFL-------DSSVLSAKDR 1618
             |.    .||.|:...|||.:|::.:||||::.|.::      .|.||       :|.:|...:.
Human   396 -HE----KLTRRQCHQQEAVWELLHTEASYIRKLRVI------INLFLCCLLNLQESGLLCEVEA 449

  Fly  1619 KALFSYIVPVHECSERLLTEL-----------EACWQDNIMLLGLSRCIYEIAERHFHVYVAFC- 1671
            :.|||.|..:.:...||...:           .|..|....|.|     :::....|..|:.:|
Human   450 ERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKG-----FKMFGSLFKPYIRYCM 509

  Fly  1672 EHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSK- 1735
            |.:|.|:.....|:::.   .|:.::...|..|.|..|.|...|..|.||:|:.|||:.:|..|
Human   510 EEEGCMEYMRGLLRDND---LFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKT 571

  Fly  1736 ESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQL-----------EFPSHVRA 1789
            |.|..:|...:   .:..|::.:...|....:.::...|..:..::           |....::.
Human   572 EEPRAKEAVVA---MIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 633

  Fly  1790 LAIAPVGVPRAGAKP---RFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCK-- 1849
            .....:..|..||.|   |.|:..|.|.  :..|:|:|:         .:|.|||:||||:.|
Human   634 FLHLDLTAPIPGASPEETRQLLLEGSLR--MKEGKDSKM---------DVYCFLFTDLLLVTKAV 687

  Fly  1850 RRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLEN--------------C 1900
            ::.|....:     |..|.      :.::..::|:|.....||.:....:              |
Human   688 KKAERTRVI-----RPPLL------VDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALC 741

  Fly  1901 DRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDE 1955
             |..|:.:.   :..:|.:.|:|..||.::.|.:.|.|..|..:...:...|.:|
Human   742 -RGWVDTIY---NAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEE 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	48/201 (24%)
		PH_ephexin	1805..1931	CDD:269929	31/141 (22%)
		SH3_ephexin1_like	1944..1998	CDD:212727	2/12 (17%)
PLEKHG5	NP_001252522.1	RhoGEF	409..596	CDD:214619	49/203 (24%)
		PH_PLEKHG5_G6	652..750	CDD:270064	26/123 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810