Protein Alignment Exn and arhgef3

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: XP_005161924.1
• Gene: arhgef3 / 570228
• ZFINID: ZDB-GENE-050208-773
• Length: 537
• Species: Danio rerio
• Alignment Length: 618
• Identity: 131/618 - (21%)
• Similarity: 223/618 - (36%)
• Gaps: 169/618 - (27%)

  Fly  1421 NGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGS---SGVSTGNEAGLGDELSS 1482
            |.::|..|||...|...|               ....|:.|:|..   .|..........|.||.
Zfish    10 NSSMSAGGDEASGPMVQG---------------KESFSLLSTSEKWLFKGKKRKQRKRDVDSLSL 59

  Fly  1483 EPHSLFSNEP----------------LYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEP 1531
              .||..|||                |.....||.|:.|.:.|:        ..|..::..:||
Zfish    60 --CSLDINEPSTKRVKPLSRVTSLASLIPPVKAAPLKRIGQTLQ--------RSISFRSDCRPE- 113

  Fly  1532 LVKPRPTALQLVE--PKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSL 1594
            ::.|||.:.|:|.  .|...|: ||||..:|   .:...|:|:|...|||.||:...|...::.|
Zfish   114 IMAPRPWSRQVVPTITKRRDSK-LWSETFDV---GLGHMLSSKEIKRQEAIFELSQGEQDLIEDL 174

  Fly  1595 NLLRRHFMNHNAFLDSSVLSAKDRKALF---SYIVPVHECSERLLTELEACWQ-----DNI--ML 1649
            .|.::.:  |:..|...:::..:...:|   ..::|:|   |.||:.|.....     |::  :|
Zfish   175 KLAKKAY--HDPMLKLCIMTEHELNQIFGTLDSLIPLH---EDLLSRLRDVRNPDGSTDHMGHIL 234

  Fly  1650 LGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSF 1714
            :....|:        ..|.::|.:|......|...|:......|   |:|...||....|:|.:|
Zfish   235 VHWLPCL--------ETYNSYCSNQVAAKALLDHKKQDHRVHDF---LQRCLESPFSRKLDLWNF 288

  Fly  1715 LMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIAR 1779
            |.:|..|:.:.|||:..:. |.:|....:.:.....:.::|.:|...|......|..:..||:
Zfish   289 LDIPRSRLVKYPLLLREIL-KHTPNEHPDRQHLDEAINMIQSIVAGINTQTGESECRYYKERL-- 350

  Fly  1780 QLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDL 1844
             |...|..|.|.|         ...|.|:..|||               |....:.::.|||.|:
Zfish   351 -LYLESGQRDLLI---------ESSRILICHGEL---------------KNNRGVKLHVFLFQDV 390

  Fly  1845 LLLCKRRGESCFSVFDYCPRSMLTLAAGDSL------PQLPTKDLK------------------- 1884
            |::.:                  .::..:.|      ..:|.:||:
Zfish   391 LVITR------------------AISHNEQLWYQLYRQPIPVRDLEWEDLQDGEMRVGGSIRGAF 437

  Fly  1885 --DQAGKNLILMTLLENCDRKTVELVLSCPSVSD---QQRWLQAMR-------PPEAETPG---- 1933
              ::..||  ...::..|..:|   .:.|...||   :|:||..:|       ..|:|.|.
Zfish   438 SNNERTKN--FFRVMFRCGGQT---QMHCFQASDTFNKQQWLNCIRQAKEAVGSAESEPPRSPQM 497

  Fly  1934 EKLYESWDCPQVVAKHSYESDEPDVLQLELGDV 1966
            ::..:..||.......:.|....:..|:||.|:
Zfish   498 DRERQHNDCSDSNMMDTMEDSSSEYPQMELADI 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	40/191 (21%)
		PH_ephexin	1805..1931	CDD:269929	27/162 (17%)
		SH3_ephexin1_like	1944..1998	CDD:212727	5/23 (22%)
arhgef3	XP_005161924.1	RhoGEF	159..335	CDD:279015	41/192 (21%)
		PH_RhoGEF3_XPLN	349..481	CDD:269976	32/181 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940