DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and arhgef19

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_005162265.1	Gene:	arhgef19 / 569202	ZFINID:	ZDB-GENE-090313-243	Length:	958	Species:	Danio rerio

Alignment Length:	1047	Identity:	264/1047 - (25%)
Similarity:	435/1047 - (41%)	Gaps:	210/1047 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1066 FKPH------RTRSPD-W------SKRIRDKR-----LQQKKAISCIEDDSDHYYETLSPLGNKR 1112
            |:||      |..|.| |      ::.:.|.|     |:|.:.|:..:.      |||:.:..:.
Zfish    13 FQPHLQAFHCRGESSDMWFPGSVETQALSDSREGRPLLRQHQHIAVCQQ------ETLAFIDLQE 71

  Fly  1113 HSTQLVRQSQDGNRSGGVRSSHRRSKNHSASAHTLGEHV------VISDDYDSFET---DSDDHG 1168
            .|....:.....|.|..:.|...|....|.|.....|..      .:::|.::.|.   .|..:.
Zfish    72 QSVNGFQSCTSENCSSSLCSKPLRCNGRSPSDFAKTESTDRALDDYLTEDINNVEVVQEQSWTYI 136

  Fly  1169 DGEPDLRQRNYNDSGV---DMRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKLYENTP 1230
            .|.|:....| .||||   :.||..||..|     :|         ....::...|||.   ::|
Zfish   137 TGLPETVHEN-PDSGVKGLNPRNLFLPLSP-----IY---------APGDRNSLESQQL---SSP 183

  Fly  1231 ASTLFYVECSKRTEDVYENTD-FGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLR----- 1289
            :|.|             |..| |.|:|   ..:.|.:.:             ||:|.::|
Zfish   184 SSPL-------------EGPDPFRPQR---RTSLGSIKE-------------KSIRRKMRVYSPD 219

  Fly  1290 -------------KSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFS 1341
                         ..|:.:||::.....|....||.........||.|.               .
Zfish   220 TLEASPSSPGVECDYLLPASFESFVEGGLGMVGSTIPTSQTSSPLPGLD---------------E 269

  Fly  1342 DKNCTPLPETPK--FSTVARKAK-KEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPLDPERELDA 1403
            |.:...:|.:||  .:.:...|: :|...:..|..:||........||..:|...||...|.:|.
Zfish   270 DLSLFAIPNSPKPFLNPLQEGARCQEGVNDEGRQRLGLEDCGTLQGPPLNSGTSMPLSRSRSVDN 334

  Fly  1404 EQTTSWYAEC----------GVFKQATNGAVSPRGDEPVTPTPSGH--GGVSSWYAESGLYQTSG 1456
            |:.....:|.          ..|......::|.|     ..:...|  |.:||.|..:..::.||
Zfish   335 ERRRFSASELISRLQLSQRKNSFTLKLGKSLSAR-----VASRERHLSGNLSSDYKPNSRHRFSG 394

  Fly  1457 ISVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEPLYQMYSAAKLESITRDLEAHGSSDG---- 1517
                   |||.....:..|....|.|..    ||:||::..|..::..::.| |..||...
Zfish   395 -------GSSDSGPHSPVGSAPPLPSAD----SNQPLHRRSSKQRMRKVSVD-EDGGSPPSNSKR 447

  Fly  1518 -------------YEEIGLQAKAKPEPLVKPRPTAL--QLVEPKN-----------GPSRTLWSE 1556
                         |.::.:..:.:.:...:|.....  :.|.|.|           |.:.:||.:
Zfish   448 LSRFLPSLILYQEYSDVAINREIQRQQGAEPGTDEERGESVSPGNLSPSSSFRSSRGSAFSLWQD 512

  Fly  1557 IPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKAL 1621
            ||:|..|..|...::.||.|||||||::||||||::||::...|||..:...:  .|..::|:.|
Zfish   513 IPDVRSSGQLDNFSNEERKLQEAKFELVTSEASYIRSLSIAVDHFMMSSELCE--CLGTQERQWL 575

  Fly  1622 FSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKE 1686
            ||.:..|.|.|||.|.:||...:.:|:...:...:.:.......||:.:..:|...::|.:||.:
Zfish   576 FSKLPDVKEVSERFLQDLERRLEGDILRFDVCDIVLDHCPALRRVYLPYVTNQAYQEQTYQRLLQ 640

  Fly  1687 SKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTL 1751
              |:..|...|.|||..|.|..|.|.|||:||.||||||.:|::.:..:.:|.:|:|..:.| .|
Zfish   641 --ENARFPGILARLEEDPICQRLPLTSFLILPFQRITRLKMLVENILKRTTPGSRDEDTATK-AL 702

  Fly  1752 ALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHL 1816
            ..::|::.:||.:....::..||..:.:::.|...:..|.          ::.|:|||.|||..:
Zfish   703 NELKKIIKECNSSVQSMKRMEELIHLNKKIHFEGKIFPLI----------SQSRWLVKHGELLEV 757

  Fly  1817 LWRGEDAKLTFGK-RLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPT 1880
              ..::..::..| :||...:|..||:|.|||.:|:....|.||.:.           .:..|..
Zfish   758 --DTQNLSISGSKFKLTTRPVYLHLFNDCLLLSRRKESWKFMVFVHA-----------KIEDLKV 809

  Fly  1881 KDLKDQAGKNLILMTLLENCDRKTV--ELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCP 1943
            |||..:.......:..|:.|:.:.:  :::|..|:.|.:|||:.||.|.:..|..|:..|:.|..
Zfish   810 KDLSQKLQGISGFIFYLQLCEGQQLKHQILLKSPTESSKQRWITAMFPSDPTTAIEQTNENDDLS 874

  Fly  1944 QVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEELNSAHVRARN 2008
            ||....||::.|.|.|.||..|::.......|||.:|.|:.||..||||.:|.||:.|...|.||
Zfish   875 QVQCIRSYQAQEHDELTLEKADILQAVTITSDGWVEGIRLSDGERGWFPKTYVEEITSRSARLRN 939

  Fly  2009 LKQRHRL 2015
            |::..|:
Zfish   940 LRENIRI 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	62/181 (34%)
		PH_ephexin	1805..1931	CDD:269929	36/128 (28%)
		SH3_ephexin1_like	1944..1998	CDD:212727	22/53 (42%)
arhgef19	XP_005162265.1	RhoGEF	537..713	CDD:279015	61/180 (34%)
		PH_ephexin	735..862	CDD:269929	37/149 (25%)
		PH	748..855	CDD:278594	32/119 (27%)
		SH3_ARHGEF5_19	875..929	CDD:212873	22/53 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5805
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25760
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12845
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910