DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and arhgef16

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_005167338.1	Gene:	arhgef16 / 567180	ZFINID:	ZDB-GENE-081104-446	Length:	662	Species:	Danio rerio

Alignment Length:	757	Identity:	211/757 - (27%)
Similarity:	330/757 - (43%)	Gaps:	139/757 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1273 VLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEI---HGSG 1334
            ||:..|.:|||          .||.:..:|.|....|.|.          .|..:.|.   .|:.
Zfish    25 VLQLDQSSGKS----------ASSINLSRLDSPEDERRTV----------VLSTQSEAARKRGTQ 69

  Fly  1335 ELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPLDPER 1399
            :|              .||...|..:.|     ||..||:...|              .||...
Zfish    70 QL--------------IPKSLAVTSRPK-----NRHHTTVVTLP--------------VPLQAS- 100

  Fly  1400 ELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSG 1464
            |:..|...|         .|.:| ||.|.:.   ...|....::|.:.: |..|...:|..|...
Zfish   101 EIGWEDYDS---------DAGDG-VSLRRNR---RNKSYRAAITSLHLD-GELQPESLSPVSDEK 151

  Fly  1465 SSGVSTGNEAG----LGDELSSEPHSLFSNEP-LYQMYSAAKLESITRDLEAHGSSDGYEEIGLQ 1524
            .......|::|    ||...:.:....|.:|| .||       |...|.|.....|...||:
Zfish   152 VVSPKQANKSGRKRTLGRIRNRKHAGSFKDEPRFYQ-------EIKERGLNVSSLSTEEEEL--- 206

  Fly  1525 AKAKPEPLVKPRPTALQLVEPKNGPSRTL-WSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEA 1588
                 .|:..|...  |.:..||..:..: ||::|:|....||..:|..||..||..|||||||.
Zfish   207 -----SPVGPPGED--QGIVVKNYRAAYITWSQLPQVKDLGILDFITPEERKRQEVIFEIITSEY 264

  Fly  1589 SYLKSLNLLRRHFMNHNAFLDS----SVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIML 1649
            ||..||::|.|||.      ||    ..::|.:...|||.|..:.:.|:|...:|:...|.|.::
Zfish   265 SYQHSLSILVRHFK------DSVDLRKTMTATEHHHLFSNISVIQDVSKRFFEDLDKRHQANPVI 323

  Fly  1650 LGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSF 1714
            ..:|..:...|.:||..|:.:|.::....|||::|..|..  ||::.|:::|.|..|.||.:.||
Zfish   324 ERISDIVATYATKHFEPYIVYCSNETFQQRTLQKLLSSNS--AFRETLKQIETSEDCGGLPMLSF 386

  Fly  1715 LMLPMQRITRLPLLIDAVFSKESPLNREEYES-WKLTLALVQKVVGQCNEAANRWEQAFELERIA 1778
            |:|||||:||||||:|.:..|.:....|.|:: |  ....:.|:|..||:.|.|.|:..::..|.
Zfish   387 LILPMQRVTRLPLLMDTICEKTTKETAEYYKACW--AFKAISKLVKSCNDGARRMERTEQMYTIQ 449

  Fly  1779 RQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSD 1843
            :|:||..      |.|..:.   :..|:|.|.|||....   :|..: |.|..:..|.|.|||:|
Zfish   450 KQMEFGK------IKPFPLV---SSSRWLKKSGELAVYT---DDLSI-FRKAFSFKSYYLFLFND 501

  Fly  1844 LLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELV 1908
            :|::.|::.|..:.|.||.           ::.::..::....:..||.|| :..|.|.::.:||
Zfish   502 VLIVTKKKSEESYVVLDYA-----------TVEKVEVEEEMSDSKLNLKLM-MNPNSDGRSEQLV 554

  Fly  1909 LSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKL 1973
            |...:...:.:|:.|:|    :.......::.|.||..|..:|....||.|.|:..:||.|.:::
Zfish   555 LVAENKLVRAQWVTALR----DVKQTSSIDNDDLPQYEATKAYLPKAPDELSLQQAEVVIVIQEV 615

  Fly  1974 PDGWYQGERIRDGAVGWFPGSYTEELNSAHVRARNLKQRHRL 2015
             :||..|||:|||..||||.|...::.:......|:::..||
Zfish   616 -EGWCYGERMRDGERGWFPASCATQITNRTAMENNIQRMERL 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	68/186 (37%)
		PH_ephexin	1805..1931	CDD:269929	33/125 (26%)
		SH3_ephexin1_like	1944..1998	CDD:212727	23/53 (43%)
arhgef16	XP_005167338.1	RhoGEF	255..434	CDD:279015	68/188 (36%)
		PH_ephexin	456..577	CDD:269929	35/149 (23%)
		PH	469..574	CDD:278594	32/124 (26%)
		SH3_ARHGEF16_26	586..639	CDD:212871	23/53 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5805
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12845
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.040