DRSC/TRiP Functional Genomics Resources

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Protein Alignment Exn and itsn2a

DIOPT Version :9

Sequence 1:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster
Sequence 2:XP_021324162.1 Gene:itsn2a / 566412 ZFINID:ZDB-GENE-041014-84 Length:1666 Species:Danio rerio


Alignment Length:1759 Identity:330/1759 - (18%)
Similarity:610/1759 - (34%) Gaps:520/1759 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   292 GLSLSAASAQSG-GSSESLQTTTTSSSTPTTHSS--VTSSTGRSGGRRKYSFKTHAGKSYHQHHH 353
            ||:.|.:....| .||.|..||:.:|::|.|.||  ....:.|...|:.::........|..  .
Zfish   180 GLTKSHSLLDLGSSSSNSSSTTSLASNSPKTSSSDWAVPQSSRLKYRQLFNSLDKLMSGYLS--G 242

  Fly   354 PSRRTSNMDSSNGGISMVAKLTHQFNEIIQKDAKLLEQVKRNNGVWISRGTHVYKIVEKPTSEGK 418
            |..|.: :.:||  ::.....|..|...:.:|.:|..:.       .....|:.::.:    .|:
Zfish   243 PQVRNA-LTASN--LTQTQLATIWFLADVDRDGQLRAEE-------FILAMHLVEMAK----TGR 293

  Fly   419 GLP-NADDNRISTVQRNIKKFERLEKPSVPLKSEQLMRKHLELMRGSSLSRGPRIKRNLKLPPGS 482
            .|| ....:.:....|..|..:.|..| |||.|.:|:...|.....|::|...:::.|.:.....
Zfish   294 PLPLTLPPDLVPPSLRTTKSCDLLNGP-VPLISTELIEPELPQKNKSNVSYEDKLRENFQRGNAE 357

  Fly   483 VGIPELAIVSEELKTPTSEEQAKKPKSVQNESQPNHPEELNQSNDKPSDELDLIMGEEGDEEELR 547
            :....||:..::.:   .||:.::.:..:.|.:.....|..:..::.:.|:::    ....||.|
Zfish   358 LEKRRLALQEQQRR---EEERRREEERREEEKRQQKEREERERREREAREMEI----RRQREEER 415

  Fly   548 QKQRKHKYASIYEKLRFTFAKGRKSASPSPTKAQIREEVSIDEESIKDSTSEDMVTRKEDFTLDL 612
            :.:|:.:.....|:.|....:.|:.|     :.|.|.|       .:.|...::.|:||....|:
Zfish   416 RMERQRELERQREEERLKELERREEA-----ERQRRRE-------WEKSKRVELQTQKEKEQNDI 468

  Fly   613 PKEVIPRAEDLEDSSHALLVSPCFEADAKILDALEAVDLKLKVLNPLNDVTTADGERELLLAAND 677
            .:        |:|...:|.:.            ||||..|.|.::  :.:..|..:|:...|..:
Zfish   469 QR--------LKDRKRSLEIE------------LEAVGNKHKQIS--SQLRDAKSKRQGQWAELE 511

  Fly   678 DFEQR----ILPNSSFVYQAANKQYSNNQI------LLNQAVNVT------LVNAIEGEQMIMEQ 726
            ...||    |...:|...|....|...||:      |.::.|:.|      |:|.:  :|.:.|:
Zfish   512 LINQRRDVCITDINSLQLQFDEMQRQLNQLGPEKQRLADRLVHFTQNISSPLINDV--KQSVCEK 574

  Fly   727 -KQLMKVRD-LELTERDIDQPLKRAEKSPEKDDTLEPESLYEPITPVMDETKTEAQTS------- 782
             :...|::: |::.||:....|.:.|:..::...:|           ||:...:...|       
Zfish   575 DRSCRKLKEQLDVLERETTAKLSQMEQYNKEIKFVE-----------MDDCVLQGLLSLLGCLTN 628

  Fly   783 --SLFKIYTKKSELVEDIYQTVEEASTVEVKPNNWLEGYESIAGSQEACPLTYDGYESFAPEEVV 845
              .|.|...:|....:|:.:.:....:.::|.   |:.:..                  ..||..
Zfish   629 LFLLIKELRQKQSQQQDVLEQLRRVRSDKLKE---LQRHRK------------------EEEERK 672

  Fly   846 TTPTTPSATGTLGRNTRDELPELPKPKRVLNKSPIPLR------------PAPPKPQAKE----- 893
            ......:|........|.|..|..:.:::..:....||            .|..:.:|||     
Zfish   673 RKKEEEAARQAQLEQERLEQEEAERQRKLAQEREAKLREEQQRQALARLLEAQEQARAKEEKRRA 737

  Fly   894 SEEDENIYDTIKGCYESMHCKATSSSSSGEATLTTDTISLSSNCYESISHIRRSRVATTQNQGHG 958
            .|::.|..|        :|.:::...:|.|..:....:.....| .|::..|.....|.:|    
Zfish   738 EEKERNELD--------VHTQSSLPFNSTENNILQPVVIPEVTC-SSLTTYRALYPFTARN---- 789

  Fly   959 SAGSCIQLSSSGSTLTISSDHKTNSLYESSLAAAGCVVYGSASVGCRSSLGSSAGSRDSGKPGDK 1023
                       ...||:.:|... .:.||::...|. :|||.| |.|.....|...|.|     |
Zfish   790 -----------SDELTLEADCFI-QVDESTVRETGW-LYGSYS-GNRGWFPESYAERCS-----K 835

  Fly  1024 RSSIAGSSDNSDAWVDISDGEIGQATTDATANEAQFI-VVRERFK-PHRTRSPDWSKRIRDKRLQ 1086
            .|....::                |.|::||..|.:. :.|...: |..|.:|      .....|
Zfish   836 DSQTQPTA----------------AETESTAPSANYPGIPRVDIEGPTPTHTP------VSTNTQ 878

  Fly  1087 QKKAISCIEDDSDHYYETLSPLGNKRHSTQLVRQSQDG-------NRSGGVRSSHRRSKNHSASA 1144
            ..:|::..|..:    :|.|.||..:.....|.:.|:.       .:.|....||          
Zfish   879 HSQAVALCEWSA----KTDSHLGFCKDDIITVLEKQENWWYGELKEKRGWFPCSH---------- 929

  Fly  1145 HTLGEHVVISDDYDSFETDSDDHGDGEP---DLRQRNYNDSGVDMRNHRLPKPPPPQNQVYEFVR 1206
                ..||.:::..|           ||   .:.:...:|||:                :.|:| 
Zfish   930 ----VSVVTTNNTQS-----------EPLYSSVEEIEVSDSGL----------------LDEYV- 962

  Fly  1207 KFKDFISSKKSPKGSQQKLYENTPASTLFYVECSKRTEDVYENTDFGPERIPAPETKGPVHQEQA 1271
                             .||                   .||:.:.|.....|.:          
Zfish   963 -----------------ALY-------------------TYESPESGDLTFSAED---------- 981

  Fly  1272 PVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYV--EDPEGSLPALPLEPEIHGSG 1334
             |:...:|.|:..|     ..:|..      :.|.|:.   ||  ::|:.:..|:|         
Zfish   982 -VVLVTEKEGEWWR-----GCIGDQ------TGLFPSN---YVKPKEPDTASSAVP--------- 1022

  Fly  1335 ELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPLDPER 1399
                  |.|     ||..:.:||:                           |..|..:..|.|.:
Zfish  1023 ------SKK-----PEIAQVTTVS---------------------------PATTPEQLSLTPGQ 1049

  Fly  1400 ELDA--EQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASS 1462
            .:..  :.:.||:.          |.:..||.:                .:.|.:|:|.:.:.  
Zfish  1050 LIVVLHKNSNSWWL----------GELQARGKK----------------RKKGWFQSSNVRLL-- 1086

  Fly  1463 SGSSGVSTGNEAGLGDELSSEPHSLFSNEPLYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKA 1527
                      ||..| :::..|      :||.|:.:....::..:|           |:..|...
Zfish  1087 ----------EANSG-KITPAP------QPLCQVIAMYDYKAANKD-----------EMSFQKGQ 1123

  Fly  1528 KPEPLVKPRP-------TALQLVEPKN--------GPSRTLWSEIPEVIHSCILPTLTSRERSLQ 1577
            ....|.|..|       ..:..:.|.|        .||:...:::      ..|.::.:.||..|
Zfish  1124 LITVLNKDNPDWWKGEVAGVTGLFPTNYVKMTTECDPSQQWCADL------LSLDSMCTEERKRQ 1182

  Fly  1578 EAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELE-- 1640
            ....|:|.:|.|||:.|.|....|  :....:|..|:..:...:|.....:..||.:||..|.  
Zfish  1183 GYIHELIQTEESYLEDLELAVEVF--YKPMAESGRLTEAEISMIFVNWRELIMCSTKLLKALRVR 1245

  Fly  1641 ---ACWQDNIMLLG--LSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERL 1700
               |..:..:.::|  ||.   |::  |...|:.||..|......|:  :::.:||.|:..|:::
Zfish  1246 KKTAGERMPVQVVGDILSS---ELS--HMQAYIRFCSCQLNAAALLQ--QKTDKSLDFKLFLKKI 1303

  Fly  1701 EASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAA 1765
            .::..|.|:.|.|||:.|||||||.||||..:.....|.: .::.:.:..|...:::..|.|||.
Zfish  1304 ASNYRCKGMPLSSFLLKPMQRITRYPLLIKNILENTPPAH-ADHSNLQAALEQAEELCSQVNEAV 1367

  Fly  1766 NRWEQAFELE---------RIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGE 1821
            ...|.:..||         .:...|.|.|....|.            ||.|:..|:| |      
Zfish  1368 REKENSDRLEWIQNHVLCDGVIEHLVFNSLTNCLG------------PRKLLHSGKL-H------ 1413

  Fly  1822 DAKLTFGKRLTKISIYAFLFSDLLLL---CKRRGESCFSVFDYCPRS-------MLTLAAGDSLP 1876
                   |..:...::|.||:|.|||   .|:...|...:|:  |.|       ...:...:.|.
Zfish  1414 -------KTKSSKELWALLFNDFLLLTYTSKQFSSSPDKLFN--PNSNTQYKMYKTPVFLNEVLV 1469

  Fly  1877 QLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPP-----EAE-TPGEK 1935
            ::|:....|..      :..:.:.||   ...|...:::::..|:|.::..     |.| ...||
Zfish  1470 KMPSDPSSDDP------VFHISHIDR---VYTLKTDTINERTTWVQKIKAASDHFIETEKLKREK 1525

  Fly  1936 LYES 1939
            .|::
Zfish  1526 AYQA 1529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 52/188 (28%)
PH_ephexin 1805..1931 CDD:269929 28/141 (20%)
SH3_ephexin1_like 1944..1998 CDD:212727
itsn2aXP_021324162.1 EH 7..92 CDD:197477
EH 214..293 CDD:197477 12/94 (13%)
SMC_N 453..>727 CDD:330553 56/329 (17%)
SH3_Intersectin2_1 776..832 CDD:212921 16/73 (22%)
SH3 881..932 CDD:327375 11/68 (16%)
SH3_Intersectin_3 960..1011 CDD:212772 17/112 (15%)
SH3_Intersectin2_4 1028..1086 CDD:212927 14/110 (13%)
SH3 1101..1154 CDD:327375 9/63 (14%)
RhoGEF 1181..1364 CDD:238091 53/192 (28%)
PH_13 1383..1523 CDD:318790 33/176 (19%)
C2_Intersectin 1524..1658 CDD:176021 3/6 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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