Protein Alignment Exn and arhgef11

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_001027010.1
• Gene: arhgef11 / 565268
• ZFINID: ZDB-GENE-070604-1
• Length: 1417
• Species: Danio rerio
• Alignment Length: 1088
• Identity: 228/1088 - (20%)
• Similarity: 359/1088 - (32%)
• Gaps: 316/1088 - (29%)

  Fly  1111 KRHSTQLVR--------------QSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSFE 1161
            ::|:|:::|              :.|..|.|..:.....|:|..::..     .|.|..|.|...
Zfish   182 QKHATEILRKMLEQEEAELQNLLEEQSRNPSVSLEERIERAKRRASQV-----RVKIQQDVDGTR 241

  Fly  1162 TD-------------SDDHGDGEPDLRQRNYNDSGVDMRN---HRLPKP-------------PPP 1197
            :|             |.|..:|:.::.:..::.....:||   ||....             |..
Zfish   242 SDAVANYLTAGEGRLSIDSSEGDVEVCESPFSSPSSFLRNPLIHRQTSDTHTSDSGKMQIIGPEE 306

  Fly  1198 QNQ-----VYEFVRKFKDFISSKKSPKGSQQKLYEN-------TPASTLFYVE------------ 1238
            :.:     :.|....|:|....|..|  :...::..       .|...|||:.
Zfish   307 EEEDDGYTINEMDGPFQDIELLKSRP--AHMTVFMRYVFGQLLDPNPLLFYLSVEAYLGSSPKDA 369

  Fly  1239 -------CS-----------KRTEDVYENTDFGPERIPAPE-TKGPVHQEQAPVLRAKQKNGKSL 1284
                   ||           |..|:...:.:   .|:.|.| .:||:.:.|..||...|...:..
Zfish   370 RSLAPQICSHFLDHDAPLKIKVREEFLTDIE---NRLHAQEDIRGPLSELQQQVLPDIQDQLQDY 431

  Fly  1285 RSRLRKSLVGSSFDTKQLSSL--APTRSTFYVEDPEGSLPALPLEPEIHGSGELDSG-------- 1339
            |::....| ||.|....|..|  .|.:....|:....:|..:..:.|...|..|.|.
Zfish   432 RNKQTMGL-GSLFGESDLQQLDGDPVKEKQVVDKQIVALWEILSKHEEDRSSPLASAVHLYLRHS 495

  Fly  1340 ---FSDKNCTP--LPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPP------PPPMTGNKS 1393
               ..|....|  :.|..|:.....||||.:.|.|.|.....:.|    |      .|..|...:
Zfish   496 GIKLRDSKVFPGLMSEKEKWLPFFPKAKKLSSAKRERDGEDKKRN----PILKYIGKPRSTSQST 556

  Fly  1394 ---PLDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTS 1455
               ||.|.........       .:.:|..:.:.|....|......||..|..|  .||   .|.
Zfish   557 FHVPLSPTEVRPGSVR-------NIIQQFESNSDSLEDGELEGQRLSGSFGEDS--MES---PTI 609

  Fly  1456 GISVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNE-------------PLYQMYSAAKLESITR 1507
            .:.:|.|........|...|.|......|.|....:             ||:...|::...|..|
Zfish   610 SVRLARSESLKAQGEGRRRGGGTGAEFVPRSRSDVDMEDCEEREGPGLRPLHHSASSSASSSSAR 674

  Fly  1508 DLEAHGSSDGYEEIGLQAKAKPEPLVKPR--------PTAL---------QLVEPKNGPSRTLWS 1555
            .||                 .|.|...||        |.:|         .:::..|      |.
Zfish   675 SLE-----------------NPTPPYTPRSQRRIVEVPVSLLPDAPALDEDVIDSHN------WQ 716

  Fly  1556 EIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKA 1620
               :.:...||.:|||||...|...:|:.|:|.|:|::|.:|.:.|....    .||||.::...
Zfish   717 ---DTVEPHILASLTSREIDRQAVIYELFTTEVSHLRTLRVLDQVFYQKM----QSVLSPEELSC 774

  Fly  1621 LFSYIVPVHECSERLLTELEACWQDNIMLLG-----LSRCIYEIAERHFHVYVAFCEHQGRMDRT 1680
            :|..:..|:|....|...::.| ::::::.|     |:|...|..::........|..|......
Zfish   775 IFLNLRQVYELHASLCESMKKC-RESVIVQGIGDIMLARFEGEAGDQFEEQVSHLCSQQSPALEL 838

  Fly  1681 LRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVF------SKESPL 1739
            ::. |:.|:. .|...::..||||.|..|.|...|:..|||:|:.|||:|.:.      |.:.||
Zfish   839 IKN-KQRKDP-RFAHLIQECEASPHCRRLQLKDLLVSEMQRLTKYPLLLDNIIKYTETSSPDLPL 901

  Fly  1740 NREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAG--- 1801
            .|.       ..|..:.::.:.||.....|....|.:..|:|:      |..:..:..|.|.
Zfish   902 LRR-------AQACCRGILQEVNEDVRETEHRHLLSQYQRRLD------ATPLERLANPVAAQFR 953

  Fly  1802 ---AKPRFLVKRGELTHLLWR-GEDAKLTFGKRLTKISIYAFLFSDLLLLCKR----------RG 1852
               ...:.:|..|.||   || |:|         ..|.|.|.|.||||||.:|          ..
Zfish   954 NLDLTTKRMVHEGPLT---WRVGKD---------KAIEIQALLLSDLLLLLQRGPDDRLILRCPS 1006

  Fly  1853 ESCFSVFD----YCP----RSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLE-NCDRKTVELV 1908
            .|...|.|    :||    .|.|..........|......::....|:..|||| |..:..:|..
Zfish  1007 RSLGGVTDLKTPFCPVVCLDSCLVRPVATDNKALYVISTSERQIYELVAGTLLEKNTWKDQLEKT 1071

  Fly  1909 LSC--------PSV-------------SDQQRWLQAMRPPEAE---------TPGEKLYESWDCP 1943
            :|.        |:.             :||....::...|:.|         ||.:...|   ||
Zfish  1072 ISAAAQGGSTKPNTPRFRSPGAGVRLSADQSEGSESRMYPDREDEMVLSPVVTPADAAEE---CP 1133

  Fly  1944 QVVAKHSYESDEPD--------VLQLELGDVVN----VSRKLPDGWYQ 1979
                     .::||        |.:..|.||..    :.|.|.|||.|
Zfish  1134 ---------DEDPDPGQKNKAGVAESALQDVETLRQLIFRDLEDGWSQ 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	47/192 (24%)
		PH_ephexin	1805..1931	CDD:269929	40/175 (23%)
		SH3_ephexin1_like	1944..1998	CDD:212727	12/48 (25%)
arhgef11	NP_001027010.1	PDZ_signaling	49..123	CDD:238492
		DegQ	<71..140	CDD:223343
		RGS_PDZRhoGEF	300..446	CDD:188707	28/151 (19%)
		RhoGEF	737..918	CDD:279015	47/194 (24%)
		PH-like	935..1075	CDD:302622	39/157 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910