Protein Alignment Exn and arhgef12a

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: XP_009290006.1
• Gene: arhgef12a / 562455
• ZFINID: ZDB-GENE-121017-3
• Length: 1357
• Species: Danio rerio
• Alignment Length: 1331
• Identity: 251/1331 - (18%)
• Similarity: 429/1331 - (32%)
• Gaps: 401/1331 - (30%)

  Fly   928 TDTISLSSNCYESISHIRRSRVATTQNQGHGSAGSC--IQLSSSGSTLTISSDHKTNSLYESSLA 990
            ||.:...|.|.          ||..:.:..|....|  ||...:|..||:|.|   |.::...:.
Zfish    42 TDVLVQKSGCV----------VADRRPESCGLVQRCVIIQKDENGFGLTVSGD---NPVFVQLVK 93

  Fly   991 AAGCVVYGSASVGCR------------------------SSLGSSAGSRDSGKPGDKRSSIAGSS 1031
            ..|..:......|.|                        |.:..:...|..|.|
Zfish    94 QDGAAMRAGVQTGDRIIKVNGTLVTQSNHVEVVKLIKSGSYVALTVLGRPPGLP----------- 147

  Fly  1032 DNSDAWVDISDGEIGQATTDATANEAQFIVVRERFK-PHRTRSP--DWSKR--IRDKRLQQKKAI 1091
                 .:.:.:.::|..:.|...:  .||.....:. ..||.||  .|.:.  :.::|:..::
Zfish   148 -----QIPLPEVDVGLESPDVFGD--PFITSPNSYNAAERTSSPLVSWEENSALHNQRMDSRR-- 203

  Fly  1092 SCIEDDSDHYYETLSPLGNKRHSTQLVRQSQDGN-----------------RSGGVRSSHRR--- 1136
            :.::|..|            ...:..:|.|:||:                 ....|.|.|||
Zfish   204 TGLKDQQD------------TQESPCLRNSEDGSWAEEDQYKRDFSPEAFWSGNSVPSVHRRFYP 256

  Fly  1137 -SKNHSASAHTLGEHVVISDDYDSFETDSDDHGDGEPDLRQRNYNDSGVDMRNHRLPKPPPPQNQ 1200
             |......::.........|.::|..:...|:|.   ||      ||       |.|........
Zfish   257 ASPESQRDSNCSSPKSTPRDSFNSCPSPEVDYGS---DL------DS-------RFPSTVGSPRL 305

  Fly  1201 VYEFVRKFKDFISSKKSPKGSQQKLYEN----------------------TPASTLFYVEC---- 1239
            |.|.:....|...|::.....|...:::                      .||..|.|:..
Zfish   306 VSEIIAAEDDDFDSEQEQVNGQCSCFQSIQLLKTRPAHLAAFLHHVISQFDPAPLLCYLYADLYK 370

  Fly  1240 ---SKRTEDVYENTDF--------------------------GPERIPAPETKGPVHQEQAPVLR 1275
               ||.|..::  |||                          .||.||....:..:...|..:..
Zfish   371 QTNSKETRRIF--TDFLTFFIDRGANLKVTVPESISSELERRRPELIPEELHRQYIQTMQETLFP 433

  Fly  1276 AKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGF 1340
            ..|:|.:..|   :|..:|.:....:||.|          |.|    .|.::.|...:..:.|..
Zfish   434 DVQRNLEDFR---QKRSMGLTLADTELSRL----------DSE----QLAVDRERACAESILSKI 481

  Fly  1341 SDKNCTPLP-ETPKFSTV-----------ARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKS 1393
            .|...|..| |..|.||:           ..:||::.....:|..|...|:       .:..:|:
Zfish   482 DDVLLTSQPTEEEKCSTIQYVIFMYMKHLGVRAKEQRNLESKRVRINFLPS-------KLRKSKT 539

  Fly  1394 PLDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQ--TSG 1456
            ..|.|.:|.              |......|.||....:...|||..|.|       :.|  ...
Zfish   540 EKDGEEKLK--------------KSRFPIRVPPRWPGRLDSVPSGRVGDS-------IKQRPQKQ 583

  Fly  1457 ISVASSSGS----SGVSTGNEAGLGDELSSEPHSLFSNEPLYQMYSAAKLESITRDLEAHGS--- 1514
            :|..:..||    :|...|:::..|.:|...| .|.::.|....||:.. :...||.|.:.|
Zfish   584 MSQPALGGSELIDAGRLRGSQSSEGSDLLHSP-GLITSSPFSAPYSSPS-DPSGRDSEFNMSPSA 646

  Fly  1515 -----SDGYEEIGLQAKAKPEPLVKPRP-------TALQLVEPKNG----------PSR------ 1551
                 |||.:        ..:||....|       ...||.|.::|          |||
Zfish   647 VVPRLSDGLQ--------SGDPLDSIYPPCDYIPYNVDQLDEDRDGDRPPDVGTPKPSRRFEDLQ 703

  Fly  1552 -------TLWSEI-----PEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHF--- 1601
                   .::|::     .:::...:|..||..|...||...|:..:|.::::.|.:|.:.|
Zfish   704 SEDDQGSDVYSDVDPPNWQQLVGRDVLAGLTPHEIKRQEVINELFYTERAHVRMLKVLDKVFYQK 768

  Fly  1602 MNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDN----IMLLG---LSRCIYEI 1659
            :|.:     ::|...|.|.:|:.:..:.:...|::.::.|..:.|    |..:|   ||......
Zfish   769 LNRD-----NILPPADIKYIFTNLEEIIQLHVRIVDQMTAICKKNETSVIDHIGDELLSWFSSGE 828

  Fly  1660 AERHFHVYVAFCEHQGRMDRTLRRLK-ESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRIT 1723
            .|:.......||.:|   ...|..:| ..|:...|...::..|::..|..|.|...:...|||.|
Zfish   829 EEKIKQAVGTFCSNQ---PFALELIKSRQKKDQRFSSFMQEAESNRLCRRLQLKDIIPAEMQRFT 890

  Fly  1724 RLPLLID--AVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSH 1786
            :.|||:|  |.::.||    ||.:..:......::::...|::....|....||...|:|:..|
Zfish   891 KYPLLMDNIAKYTDES----EEKDKVRRAAECCRQILNHVNQSVKESENKQRLEDYQRRLDLSS- 950

  Fly  1787 VRALAIAPVGVPRAGAKPRF-------LVKRGELTH---LLWRGEDAKLTFGKRLTKISIYAFLF 1841
                       .:....|..       |.|| ::.|   |.|:....|        .|.:|..|.
Zfish   951 -----------LKQSENPMISEFKNLDLTKR-KMVHEGPLSWKINKDK--------TIELYTLLL 995

  Fly  1842 SDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVE 1906
            .|:|:|.:::.|          |.:|...:.:......||.:.....|...::......|.::..
Zfish   996 EDILVLLQKQDE----------RLILRCHSKNLAGTAETKHIFSPIIKLSTVLVRSVATDNRSFF 1050

  Fly  1907 LV-----------LSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQ---------------- 1944
            ::           |...:||:|:.| |......||....|.:.....||
Zfish  1051 VISMSKNGAQIYELMAQTVSEQRMW-QRQITQRAEVMNTKPHSVIPLPQHDGDRDGVELSKFSKG 1114

  Fly  1945 --VVAKHSYESDEPD------------VLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSY 1995
              .::..|.:|.|.|            |.....|:...|:|...|..||...:.:       |..
Zfish  1115 SDRISTGSIQSAEKDGEFSPSAALRDCVPDTNPGEEDQVARAGRDASYQDSELLN-------GRE 1172

  Fly  1996 TEELNSAHVRARNLKQRHRLLTFTATYLESQ 2026
            |:.|:.:......||....|.....|.|.:|
Zfish  1173 TDSLSCSSKADEALKTLAALKQVLLTQLMAQ 1203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	42/194 (22%)
		PH_ephexin	1805..1931	CDD:269929	27/146 (18%)
		SH3_ephexin1_like	1944..1998	CDD:212727	14/83 (17%)
arhgef12a	XP_009290006.1	PDZ_signaling	66..140	CDD:238492	13/76 (17%)
		RGS	308..524	CDD:295367	41/234 (18%)
		RhoGEF	743..928	CDD:279015	42/196 (21%)
		PH-like	947..1083	CDD:302622	28/167 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810