Protein Alignment Exn and fgd1

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: XP_688794.4
• Gene: fgd1 / 560305
• ZFINID: ZDB-GENE-081104-33
• Length: 995
• Species: Danio rerio
• Alignment Length: 821
• Identity: 174/821 - (21%)
• Similarity: 285/821 - (34%)
• Gaps: 281/821 - (34%)

  Fly  1257 IPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEG-- 1319
            :|:|:          |.||....:..|.| .|.|||           ||.|.......|.|:.
Zfish    39 LPSPQ----------PALRRTGSSSSSPR-LLTKSL-----------SLDPGPCLGAHETPQRLC 81

  Fly  1320 SLPALPLEPEIHGSGELDSGFSD------KNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRP 1378
            |.|. ||||: |.:|..::|..|      |...||| .|| ..|..|.....:.|.||.    ||
Zfish    82 SDPG-PLEPQ-HCNGTSENGPQDVPPPPPKTRPPLP-GPK-PQVPPKPPHLQQQNARRP----RP 138

  Fly  1379 NDPP-PPPPPMTGNKSPLDPEREL----DAEQTTSWYAEC---------------------GVF- 1416
            .|.| |||||  ....|.||.:..    .||.::|  ..|                     ||.
Zfish   139 PDKPLPPPPP--SRPLPADPRQSRATMPRAEGSSS--PTCVLSLIEKFEREQIIVVPDITGGVMC 199

  Fly  1417 ------KQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQ---------------------- 1453
                  :|||.|::||:..|.:.|..|....:.:..||..|.:
Zfish   200 TPRVPDQQATPGSLSPQTSEFILPCTSLQEPLEAPLAEDELEKEEKEEEEEEDVDETEEDDSELG 264

  Fly  1454 ----TSGISVASSSGSS-----------------------------GVSTGNEAGLGDELSSEPH 1485
                ...:|:.|..|:|                             |.....::|: |.:||..|
Zfish   265 ASCSDKRLSMESGYGASDKLLDNMEMTANQSEIPSDRLSLPPAQMDGKLANRDSGI-DSISSPSH 328

  Fly  1486 SLFSNEPLYQMYSAAKL------------------------------ESITRDLEAHGSSDGYEE 1520
            |    |.|..:....::                              |...||.|  |.||..|.
Zfish   329 S----EELCFVGDEDRVGHEREICPCSPGPGISCSYVEGPDEEGAGGEEAGRDSE--GDSDLEEG 387

  Fly  1521 IGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKF---- 1581
            .|.:::..|..| :|.|.|    |.::                       |.|.|:|:..|
Zfish   388 SGDESEMNPMAL-QPLPKA----ERQD-----------------------STEMSVQQRVFNIAN 424

  Fly  1582 EIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKA--------LFSYIVPVHECSERLLTE 1638
            |::.:|.:|:..|:||      ...|....:..|:.|.:        :||.|..::
Zfish   425 ELLHTEKAYVSRLHLL------DQVFCAQLMEEARARSSFPCEMVMGIFSNICSIY--------- 474

  Fly  1639 LEACWQDNIMLLGLSRCIYE---------IAERHFHVYVAFCEHQGRMDRTLRRLKE-SKESLAF 1693
               |:....:|..|.:.:.|         |.::.......:.|:....||.:..:.. .:.|..|
Zfish   475 ---CFHQQFLLPALEKRMEEWDLNPRIGDILQKLAPFLKMYGEYVKNFDRAMELVNTWMQRSSQF 536

  Fly  1694 QQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVV 1758
            :..:..::....|..|.|...::.|:|||.|..||:.. :....|.:.::::..:.:|.|:....
Zfish   537 KTIIHNIQKEEMCGNLTLQHHMLEPVQRIPRYELLLKD-YLHRLPEDADDFKDAQKSLELIATAA 600

  Fly  1759 GQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDA 1823
            ...|.|..:.|:..:|.::...|.....:    :.|...         |:|.|   |:|
Zfish   601 EHSNAAIRKMERMRKLLKVYELLGGEEDI----VNPTNE---------LIKEG---HIL------ 643

  Fly  1824 KLTFGKRLTKISIYAFLFSDLLLLC--KRR--GESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLK 1884
            ||: .|..|....|..||:|.||.|  |.|  |:. |.|     |:.:.:   |.:      :||
Zfish   644 KLS-AKNGTSQDRYLILFNDRLLYCVPKLRLIGQK-FGV-----RARIDV---DGM------ELK 692

  Fly  1885 DQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMR 1925
            :.:..| :..|.|.:..::::|  |...:..:::.|:||::
Zfish   693 ETSSMN-VPRTFLVSGKQRSLE--LQARTEEEKRDWIQAIQ 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	36/203 (18%)
		PH_ephexin	1805..1931	CDD:269929	33/125 (26%)
		SH3_ephexin1_like	1944..1998	CDD:212727
fgd1	XP_688794.4	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910