Protein Alignment Exn and arhgef15b

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: XP_009304999.1
• Gene: arhgef15b / 555489
• ZFINID: ZDB-GENE-060810-103
• Length: 937
• Species: Danio rerio
• Alignment Length: 1198
• Identity: 282/1198 - (23%)
• Similarity: 462/1198 - (38%)
• Gaps: 307/1198 - (25%)

  Fly   866 PELPKPKRVLNKSPIPLRPAPPKPQAKESEEDENIYDTIKGCYESMHCKATSSSSSGEATLTTDT 930
            |:||....|..|.|:|.:|                                       :..|||:
Zfish     7 PDLPPKPEVKQKPPVPSKP---------------------------------------SITTTDS 32

  Fly   931 ISLSSNCYESISHIRRSRVATTQNQGHGSAGSCIQLSSSGSTLTISSDHKTNSLYESSLAAAGCV 995
            .|:.:...:|..:::......:|.:.....|..::              ..|:.:.|....|...
Zfish    33 SSVDTAASQSSGNVKNIVNKFSQPESKPPLGETVK--------------SVNTEWRSQRPPAVKP 83

  Fly   996 VYGSASVGCRSSLGSSAGSRDSGKPGDKRSSI-AGSSDNSDA------WVDISDGEIGQATTDAT 1053
            ...|.|    ||| ||||:.....|..:::|| :|..|..|.      .:..:||  |::..|..
Zfish    84 KRRSKS----SSL-SSAGNAPPLPPKTRQNSIHSGQKDELDGQERHEEGLSAADG--GRSAPDGK 141

  Fly  1054 ANEAQFIVVRERFKPHRTRSPDWSKRIRDKRLQQKKAISCIEDDSDHYYETLSPLGNKRHSTQLV 1118
            ....|    |...:......|...|.......||:..:..|      :.....|...:.....|.
Zfish   142 EGSKQ----RSERESSPLPEPQCEKNCGCMCHQQRPGMKLI------WVPISEPSDEEEEEEVLS 196

  Fly  1119 RQSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSFETDSDDHGDGEPDLRQRNYNDSG 1183
            ..::|.|.|.....:....|.         |.|..|...|..||
Zfish   197 SSTEDQNTSLAEAENEETFKE---------EPVSFSKSLDVVET--------------------- 231

  Fly  1184 VDMRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKLYENTPASTLFYVECSKRTEDVYE 1248
                     |...||         .|:|::::        .|.|                :.:..
Zfish   232 ---------KQKAPQ---------MKNFLAAR--------NLIE----------------QQLRR 254

  Fly  1249 NTDFGPER-----IPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPT 1308
            .:|.||..     ||.|:|  |::......|...::               |.:|. .|..:.|.
Zfish   255 KSDPGPPALITSVIPFPQT--PINVSNVQTLEVPEE---------------SIYDV-SLEVVTPP 301

  Fly  1309 RSTFYVEDPEG--SLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVA------RKAKKEA 1365
            |...:.:...|  |.||:|....:           |..|..:...|..:..|      :|....|
Zfish   302 RPQKHADTGTGKDSPPAIPPRMPL-----------DNRCPQIILPPSLARPASPLMPPKKRSPPA 355

  Fly  1366 KANRRRTTIGLRPNDPPPPPPPMT---GNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPR 1427
            ....:||        ||||||..|   |.:......:.:|...:|...      |..:|..:.|
Zfish   356 SPRLQRT--------PPPPPPAKTYENGRRFSNYSLKSIDENDSTEGE------KSGSNENIRP- 405

  Fly  1428 GDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEP 1492
               |...|                             ....|...||.:.||
Zfish   406 ---PRIAT-----------------------------RRQKSVDLEAEMSDE------------- 425

  Fly  1493 LYQMYSAAKL-----ESITRDLEAHGSSDGYEEIGLQAKAKPEPLVK-PRPTALQLVEPKNGPSR 1551
            |||.|:...:     .::.|:: :..|:|  .::..|....||...| |:.:..|.::..|
Zfish   426 LYQFYTETYVHKEIRRTVCRNI-SKTSAD--FQMSSQITTSPEKGEKGPKSSESQSLKQNN---- 483

  Fly  1552 TLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAK 1616
             ||.|...|..|.:|..|:..|...||:.||:||||.|||:||.:|..||:..:...::.::  .
Zfish   484 -LWREQSAVRDSGVLEKLSPEECKYQESMFEVITSEMSYLRSLRVLTEHFVESSELNETLII--M 545

  Fly  1617 DRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTL 1681
            |:|.|||.|:.:.|.|||.|.:||....:||::..:...|:..|:.||..|:.:..:|...::|.
Zfish   546 DKKTLFSNIIRIQEVSERFLKDLEERLDENIIISDICDIIHYHAQHHFPAYIDYVRNQIYQEKTY 610

  Fly  1682 RRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYES 1746
            ..|.::  :..|...:.||:.||.|..|...|||:||.|||||:.:||:.:. |.:.:..::.::
Zfish   611 SNLMQT--NTQFATVITRLQESPKCQRLPFMSFLLLPFQRITRIKMLIENIL-KRTAVGTDKEQT 672

  Fly  1747 WKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRG 1811
            ....|..|.|::.:||....:.:|..||.:|...||| ..::|:.|.        ::.|:|.|:|
Zfish   673 ASKALDSVSKIIEECNTQVGKMKQMEELIQINGMLEF-DKLKAVPII--------SQTRYLEKQG 728

  Fly  1812 ELTHLLWRGEDAKLTF-GKRLTKIS-IYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAA--G 1872
            |:..:...|     || |....|.: :|.|||:|||::..::....:.|.|:..||::.:.:  .
Zfish   729 EVLEVNKGG-----TFLGNLRPKFTPVYLFLFNDLLVIAIKKSAERYVVLDHAHRSLVQVQSYEN 788

  Fly  1873 DSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETP----G 1933
            .::|.:          ::...:|||||...:.:|.::..||.||.||||...  |..:.|    .
Zfish   789 SAVPNI----------EHCFCLTLLENHQGRQMERIMKAPSQSDSQRWLAVF--PNPDDPKNDQE 841

  Fly  1934 EKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEE 1998
            |.:||.||||||.....|.:.:.|.|.||..:::||.||..:|||:|.|:.||..||||.:...|
Zfish   842 EVIYEDWDCPQVQCVEQYVAKQSDELNLERTEIINVIRKTNEGWYEGMRLSDGQKGWFPEANVLE 906

  Fly  1999 LNSAHVRARNLKQRHRLLTFTATYLESQ 2026
            :.:.|||.|||::|:|::...|...:::
Zfish   907 ITNEHVRRRNLRERYRVIQAAAVVAKTR 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	61/181 (34%)
		PH_ephexin	1805..1931	CDD:269929	37/129 (29%)
		SH3_ephexin1_like	1944..1998	CDD:212727	22/53 (42%)
arhgef15b	XP_009304999.1	RhoGEF	511..688	CDD:279015	60/181 (33%)
		PH_ephexin	711..833	CDD:269929	39/146 (27%)
		PH	724..830	CDD:278594	35/120 (29%)
		SH3_ephexin1_like	852..906	CDD:212727	22/53 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5805
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001805
OrthoInspector	1	1.000	-	-		otm25760
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12845
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1705
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.910