DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and si:dkey-91i10.2

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_005167625.1	Gene:	si:dkey-91i10.2 / 555224	ZFINID:	ZDB-GENE-050208-441	Length:	1121	Species:	Danio rerio

Alignment Length:	959	Identity:	202/959 - (21%)
Similarity:	334/959 - (34%)	Gaps:	294/959 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1070 RTRSPDWSKRIRDKRLQQKK-------AISCIEDDSDHYYETLSPLGNKRHSTQLV----RQSQD 1123
            |..||:..|:...:|||.::       |::|.::.|     .||    |..:.:|:    .||..
Zfish   261 RITSPEEIKQEAMRRLQLRRQRSTPNLALTCRQESS-----ALS----KAQTAELICTNSAQSTP 316

  Fly  1124 GNRSGGVRSSH-------------RRSKNHSASAHTLGEHVVISDDYDSFETDSDDHGDGEPDLR 1175
            ..:...:...|             ..|||||:|            :.:|.:..|:|
Zfish   317 ERKRPPMGRLHIPTFEEFKRMRQRESSKNHSSS------------EMESCDRPSED--------- 360

  Fly  1176 QRNYNDSGVDMRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQ-QKLYENT--PASTLFYV 1237
                           ...|....|.|       :..:.|...|.|.: .:|...|  |...:
Zfish   361 ---------------TQNPERTANNV-------RTTLDSAGGPSGGEMSELISTTVVPGGPI--- 400

  Fly  1238 ECS--KRTEDVYENTDFGPERIPAPETKGPV--------------HQEQAPV----LRAKQKNGK 1282
             |:  .....::.....|.|.    |||||.              .:|...|    .:|...:|.
Zfish   401 -CTGPVARSPLHPQAAAGKEE----ETKGPAGPGATDVAVLPFPPRRESGDVPSSCCQAILLDGT 460

  Fly  1283 SLRS------RLRKSLVGSSFD------TKQLSSLAPTRSTFYVEDPEG-------------SLP 1322
            .|.|      ::|...:||:.|      :.::::..|.|.:...:|..|             :..
Zfish   461 DLSSYGAKIYKMRDGFLGSALDLIKKSCSAEIAAETPVRLSREPDDVTGITQPCHQSACVAMTTQ 525

  Fly  1323 ALPLEPEIHGSGELDSGFSDKNCTPLPETPKFST-VARKAKKEAKANRRRTTIGLRPNDPPPPPP 1386
            |...|.....:|.  .|.:|..|...|...:.|: .|.:..:..||.|.   ..|||:...|.|.
Zfish   526 ACGEEACTEPTGR--RGKADTECVSGPGCRRSSSDAAYELAESVKAQRE---CRLRPHYSDPMPA 585

  Fly  1387 PMTGNKSPLDPE-----------RELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHG 1440
            ..|..|. |:.:           |:.|....|:            .|...|||:|    ...|.|
Zfish   586 DATKRKQ-LEMKIAAAARLHIHRRDRDTAAGTA------------RGRSEPRGEE----RSRGLG 633

  Fly  1441 GVSSWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEPLYQMYSA-AKLES 1504
                 ...|..::.|  :|:|.|..|||     .|..||...|      .||....:|| |::|.
Zfish   634 -----VRRSAQHRWS--TVSSLSADSGV-----VGWSDEREDE------EEPRRARHSAGAEVER 680

  Fly  1505 ITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLW---SEIPEVIHS--- 1563
            :...: .||          .|::...||                ||...|   ...|:..|.
Zfish   681 VDSGI-GHG----------LARSWRRPL----------------PSLRTWDVQQPCPDCGHKEGA 718

  Fly  1564 -----CILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFS 1623
                 |...:....||  :||..|.:.:|:||.:.|.:::..|  :.....:.:|:|:....:||
Zfish   719 HGEGMCERCSKLRTER--KEAILEFLNTESSYGEDLRIIKEEF--YCPMQSAGLLTAEQLAVVFS 779

  Fly  1624 YIVPVHECSERLLTELEACWQDNI---------MLLGLSRCIYEIAERHFHVYVAF---CEHQGR 1676
            .:..:.:.:|:....|    ||:|         .|..:  ||.||.....::..||   |..|..
Zfish   780 NVQELIDVNEKFTEHL----QDSIDQAFDQGDEDLQAV--CIGEIFLEFVNMLPAFQTYCLQQST 838

  Fly  1677 MDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNR 1741
            ....|..|::.||.|.....:.:.: :.:...:||.||||.|:||:|:.|||:..: ||.:....
Zfish   839 SVNMLNTLEKEKELLRIFLDVSQND-NTALRRMNLRSFLMAPLQRVTKYPLLLSRI-SKATNECH 901

  Fly  1742 EEYESWKLTLALVQKVVGQCN-----EAANRWE-QAFELERIARQLEFPSHVRALAIAPVGVPRA 1800
            .:|...|...:.|:..:...|     |....|. ::|..:....:......:|.|::..||..|.
Zfish   902 PDYPRLKEAKSRVESHLEHINMKTKQEGTATWSLRSFRRDSRKNREVINIEMRELSMKMVGWARE 966

  Fly  1801 GAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRS 1865
            ..  ||::: |.|       :.|:...|:.|.|.| .:..|.::..|...|
Zfish   967 ST--RFIME-GPL-------QLAQPADGQWLKKGS-KSLKFQNVQSLLMVR-------------- 1006

  Fly  1866 MLTLAAGDSLP--QLPTKD---------LKDQ-AGKNLILM--TLLENC 1900
              ||.|.|::|  .|.:.:         :||: :||..:|.  ..|.||
Zfish  1007 --TLRATDAVPDGSLESSEAVQDGVLVLIKDKSSGKFTVLREPIRLANC 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	48/198 (24%)
		PH_ephexin	1805..1931	CDD:269929	26/110 (24%)
		SH3_ephexin1_like	1944..1998	CDD:212727
si:dkey-91i10.2	XP_005167625.1	RhoGEF	737..922	CDD:279015	48/194 (25%)
si:dkey-91i10.2	XP_005167625.1	PH	<1025..1094	CDD:214574	8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900