DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and PLEKHG6

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_001371533.1	Gene:	PLEKHG6 / 55200	HGNCID:	25562	Length:	806	Species:	Homo sapiens

Alignment Length:	626	Identity:	145/626 - (23%)
Similarity:	225/626 - (35%)	Gaps:	172/626 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1382 PPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPT--------PSG 1438
            ||...|:.|          |.|.:..::........|:|.|.:.|||...:.|:        |..
Human     6 PPHEGPLQG----------LVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFA 60

  Fly  1439 HGGVSSWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEPLYQMYSAAKLE 1503
            .|        ||  |..|:|                         |..|...||
Human    61 RG--------SG--QARGLS-------------------------PMRLRDPEP----------- 79

  Fly  1504 SITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVE------PKNGP-SRTLWSEIPEVI 1561
                 .:.||   |:...||....|.:.|.|.....::|..      |:..| .|..| ||.|..
Human    80 -----EKRHG---GHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHW-EIGEGG 135

  Fly  1562 HSCILPTLTSRERSL--------------QEAKFEIITSEASYLKSL----NLLRRHFMNHNAFL 1608
            .|.:  |:....|.|              |||.:|::|:|..|::.|    :||....:|....
Human   136 DSGL--TIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRV- 197

  Fly  1609 DSSVLSAKDRKALFSYI---VPVH-----ECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFH 1665
              .:|.....:.||..:   :..|     |.....|.|..|..|. :..:||........:| ||
Human   198 --GLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQP-LDPIGLQSGFLTFGQR-FH 258

  Fly  1666 VYVAFCEHQGRMDRTLRRLKESKES--------LAFQQHLERLEASPSCCGLNLH---------S 1713
            .||.:|.   |:.:|:...:|.:|:        .|.|:........||......|         .
Human   259 PYVQYCL---RVKQTMAYAREQQETNPLFHAFVQAGQEGANPEPHPPSLQWCEKHKRSGRQMLCD 320

  Fly  1714 FLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIA 1778
            .|:.|.||||:.|||:.||. |.||..|.: |:....:..|:..:...|....:.|:...|...|
Human   321 LLIKPHQRITKYPLLLHAVL-KRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAAAA 383

  Fly  1779 RQ------LEFPS-----HVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLT 1832
            ::      ||.||     ::|..:...:..|..|      |.......||..| ..::..| |..
Human   384 QRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLG------VASEHTRQLLLEG-PVRVKEG-REG 440

  Fly  1833 KISIYAFLFSDLLLLCK--RRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMT 1895
            |:.:|.|||||:||:.|  |:.:....:     |..|      .|.:|..:.|:|   .|..|:.
Human   441 KLDVYLFLFSDVLLVTKPQRKADKAKVI-----RPPL------MLEKLVCQPLRD---PNSFLLI 491

  Fly  1896 LLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKL 1936
            .|......:..|::.|||.:|:.:||:  :..:|:...:||
Human   492 HLTEFQCVSSALLVHCPSPTDRAQWLE--KTQQAQAALQKL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	51/210 (24%)
		PH_ephexin	1805..1931	CDD:269929	34/127 (27%)
		SH3_ephexin1_like	1944..1998	CDD:212727
PLEKHG6	NP_001371533.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..91		12/73 (16%)
		RhoGEF	165..367	CDD:395496	52/211 (25%)
		PH_PLEKHG5_G6	424..522	CDD:270064	32/115 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..693
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	706..746
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..806
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810