Protein Alignment Exn and arhgef16

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: XP_012822093.1
• Gene: arhgef16 / 549614
• XenbaseID: XB-GENE-1015007
• Length: 715
• Species: Xenopus tropicalis
• Alignment Length: 803
• Identity: 215/803 - (26%)
• Similarity: 348/803 - (43%)
• Gaps: 160/803 - (19%)

  Fly  1238 ECSKRTEDVYENTDFGPERIPAP-ETKGPVHQEQAPV---LRAKQKNGKSL----RSRLRK--SL 1292
            :.|:||.:..:|..:.||:||:| |....:...|:|.   |..:|...|.|    ::::.:  |.
 Frog    42 DVSRRTLEPVDNASYIPEQIPSPVEASRVILSTQSPAAHKLGTQQMIPKGLAVATKTKVPRHHSF 106

  Fly  1293 VGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTV 1357
            ..::| ||:|:...|.|.         |.|.:.|:   ....:||:|               .|:
 Frog   107 AATTF-TKELARNDPKRI---------SAPDICLD---LSEDDLDTG---------------GTL 143

  Fly  1358 ARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNG 1422
            .|..:.:   :.|....|.:..:...|..|::
 Frog   144 KRNLRNQ---SYRAAMKGFQNFEDSEPQKPVS--------------------------------- 172

  Fly  1423 AVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSL 1487
            .:.|..::...|.|...|.....:....:.:.:|                              .
 Frog   173 TLMPVSEDASVPPPRSPGRSKKTFGRKRMQRHAG------------------------------S 207

  Fly  1488 FSNEP-LYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSR 1551
            |.::| |||.:....|.|..::    ...|..:|.|...:..|:.         .:|.....|::
 Frog   208 FKDDPRLYQEFRERGLNSNNQE----SDDDLLDEKGEAEQPVPDD---------GIVVKNYRPAQ 259

  Fly  1552 TLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAK 1616
            .:||::|||..|.||..::..||..|||.|||||||.||..||.:|.|.|......  ...::..
 Frog   260 LIWSQLPEVQESGILNKISPEERKRQEAIFEIITSEYSYQHSLGILVRLFKKSEEL--KQTITNT 322

  Fly  1617 DRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTL 1681
            :...|||.|..:.|.|:|...:||...::|..:..:|..:...|:..|..||::|.::....|||
 Frog   323 EHHHLFSNIAEIQEVSKRFFEDLEKRHKENPFIDNISDIVEHHAQNKFQPYVSYCSNEMYQQRTL 387

  Fly  1682 RRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYES 1746
            :||..:..:  |:..|:::|....|.||.:.|||:|||||:||||||:|.:..| ..:..:||..
 Frog   388 QRLMSTNGT--FKDTLKQIEMKAECGGLPMFSFLILPMQRVTRLPLLMDTICQK-MDMRTKEYGE 449

  Fly  1747 WKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRG 1811
            ....|..:.|:|.||||.|.:.|:..::..:..||||..      |.|..:..|.   |:|:|||
 Frog   450 TTHALKALSKLVKQCNEGARKMERTEQMYTLQTQLEFGK------IKPFPLISAS---RWLLKRG 505

  Fly  1812 EL-----THLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAA 1871
            ||     :.:.|:|      ||    |.|.|.|||:|:|::.|::.|..:.|.||.......:|.
 Frog   506 ELNLVEESGVFWKG------FG----KTSCYLFLFNDILIITKKKSEENYIVTDYVMMDQFAVAK 560

  Fly  1872 ---GDSLPQLP------TKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPP 1927
               ||  |||.      |...:...|..|..:.:.:|.:.|..|:||:..|:||:.||:.|:...
 Frog   561 IENGD--PQLSPPAKTGTSGPRSPNGPFLFQIHISKNSEGKQDEIVLAADSLSDRARWVAALERK 623

  Fly  1928 EAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFP 1992
            |......:.... ...||....:|.:.:.|.:.|:..||:.|.:: .||||||||:|||..||||
 Frog   624 EDNKENSRSRRG-GLRQVEIIKAYLAKQADEISLQQADVMLVLQE-EDGWYQGERLRDGERGWFP 686

  Fly  1993 GSYTEELNSAHVRARNLKQRHRL 2015
            .|..:|:.:.....||:::..||
 Frog   687 ESCAKEITNQTAVERNVQRMERL 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	64/181 (35%)
		PH_ephexin	1805..1931	CDD:269929	45/139 (32%)
		SH3_ephexin1_like	1944..1998	CDD:212727	24/53 (45%)
arhgef16	XP_012822093.1	RhoGEF	287..465	CDD:366202	64/182 (35%)
		PH_ephexin	488..627	CDD:269929	48/159 (30%)
		SH3_ARHGEF16_26	639..692	CDD:212871	24/53 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I5992
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48681
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030