DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and ARHGEF3

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_001122087.1	Gene:	ARHGEF3 / 50650	HGNCID:	683	Length:	558	Species:	Homo sapiens

Alignment Length:	503	Identity:	103/503 - (20%)
Similarity:	193/503 - (38%)	Gaps:	148/503 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1482 SEPHSLFSN---EPLYQMYS---------AAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVK 1534
            |||    ||   :||.::.|         |..|:..::.|:        ..|..:::::|: ::.
Human    64 SEP----SNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQ--------RSISFRSESRPD-ILA 115

  Fly  1535 PRPTALQLVEPKN-GPSRT------LWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLK 1592
            |||.:      :| .||.|      ||||..:|   |:...|||:|...|||.||:...|...::
Human   116 PRPWS------RNAAPSSTKRRDSKLWSETFDV---CVNQMLTSKEIKRQEAIFELSQGEEDLIE 171

  Fly  1593 SLNLLRRHFMNHNAFLDSSVLSAKDRKALF---SYIVPVHECSERLLTELEACWQDN-------I 1647
            .|.|.::.:  |:..|..|:::.::...:|   ..::|:|   |.||::|....:.:       .
Human   172 DLKLAKKAY--HDPMLKLSIMTEQELNQIFGTLDSLIPLH---EELLSQLRDVRKPDGSTEHVGP 231

  Fly  1648 MLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLH 1712
            :|:|...|:..        |.::|.:|......   |...|:....|..|:|...||....|:|.
Human   232 ILVGWLPCLSS--------YDSYCSNQVAAKAL---LDHKKQDHRVQDFLQRCLESPFSRKLDLW 285

  Fly  1713 SFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERI 1777
            :||.:|..|:.:.|||:..:. :.:|.:..:.:..:..:.::|.:|.:.|......|..:..||:
Human   286 NFLDIPRSRLVKYPLLLREIL-RHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERL 349

  Fly  1778 ARQLEFPSHVRALAIAPVGVPRAGAK------PRFLVKRGELTHLLWRGEDAKLTFGKRLTKISI 1836
            ....|                  |.|      .|.|...|||               |....:.:
Human   350 LYLEE------------------GQKDSLIDSSRVLCCHGEL---------------KNNRGVKL 381

  Fly  1837 YAFLFSDLLLLCK---RRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDL--------------- 1883
            :.|||.::|::.:   ...:.|:.::               ...:|.|||
Human   382 HVFLFQEVLVITRAVTHNEQLCYQLY---------------RQPIPVKDLLLEDLQDGEVRLGGS 431

  Fly  1884 ------KDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMR 1925
                  .::..||...::.......:|..  |......::|:||..:|
Human   432 LRGAFSNNERIKNFFRVSFKNGSQSQTHS--LQANDTFNKQQWLNCIR 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	40/191 (21%)
		PH_ephexin	1805..1931	CDD:269929	23/145 (16%)
		SH3_ephexin1_like	1944..1998	CDD:212727
ARHGEF3	NP_001122087.1	RhoGEF	158..334	CDD:395496	41/192 (21%)
ARHGEF3	NP_001122087.1	PH_RhoGEF3_XPLN	348..480	CDD:269976	27/180 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840