DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and net1

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_021330686.1	Gene:	net1 / 493607	ZFINID:	ZDB-GENE-041121-18	Length:	605	Species:	Danio rerio

Alignment Length:	469	Identity:	107/469 - (22%)
Similarity:	195/469 - (41%)	Gaps:	100/469 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1492 PLYQMYSAAKLESITRD---------LEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKN 1547
            ||.::.|.|.|.|..::         |:|....||        ::...|..||...|.....||.
Zfish    93 PLGRVTSLANLISPVKNGAVRRFGQTLQASFRGDG--------RSPGVPQQKPCSKAAAPTPPKR 149

  Fly  1548 GPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSV 1612
            ..| |||||..:|...   .|.:::|...|||.||:...|...::.|.|.|:.:  |:..|..|:
Zfish   150 RNS-TLWSETLDVHQK---GTFSTKEIKRQEAIFELSRGEQDLIEDLKLARKAY--HDPMLKLSI 208

  Fly  1613 LSAKDRKALFSYI---VPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQ 1674
            :|.::..|:|..:   :|:|   |.||.:|......:..:..:.:.:.:...| .:.|.|:|.:|
Zfish   209 MSEEELTAIFGDLDAYIPLH---EDLLDQLAKATGTDGTVRQIGKIVVDWLPR-LNAYRAYCSNQ 269

  Fly  1675 GRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPL 1739
             ...:.|  |.:.|:....|..|:|...||....|:|.|||.:|..|:.:.|||:..:. :.:|.
Zfish   270 -LAAKAL--LDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEIL-RHTPP 330

  Fly  1740 NREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIA----RQLEFPSHVRALAIAPVGVPRA 1800
            :..:..|.:..::::|.|:...|......|..:.::::.    :|.:               ||.
Zfish   331 DHPDKGSLEQAISVIQAVLADINMKKGESECQYYIDKLEYLEDKQKD---------------PRI 380

  Fly  1801 GAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCK---RRGESCFSVFDYC 1862
             .:.:.|:..|||.:             |..||  ::.|||:::|:|.:   |....||.|:
Zfish   381 -EQCKSLLCHGELRN-------------KSGTK--LHVFLFTEVLILTRPVTRNDRHCFQVY--- 426

  Fly  1863 PRSMLTLAAGDSLPQLPTKDLKD----------------QAGKNLILMTLLENCDRKTVELVLSC 1911
             |..:      .:..|..:||:|                ...||:..:...:....::..|.::
Zfish   427 -RQPI------PVQDLVLEDLQDGDVRMGGSFRGAFSNADKAKNIFRVRFQDASQGQSHTLQVN- 483

  Fly  1912 PSVSDQQRWLQAMR 1925
             .|..:|:||..:|
Zfish   484 -DVFHKQQWLNCLR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	45/184 (24%)
		PH_ephexin	1805..1931	CDD:269929	29/140 (21%)
		SH3_ephexin1_like	1944..1998	CDD:212727
net1	XP_021330686.1	RhoGEF	177..353	CDD:214619	46/185 (25%)
net1	XP_021330686.1	PH-like	367..500	CDD:327399	32/173 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840