DRSC/TRiP Functional Genomics Resources

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Protein Alignment Exn and ARHGEF35

DIOPT Version :9

Sequence 1:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster
Sequence 2:NP_001003702.2 Gene:ARHGEF35 / 445328 HGNCID:33846 Length:484 Species:Homo sapiens


Alignment Length:535 Identity:119/535 - (22%)
Similarity:185/535 - (34%) Gaps:132/535 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 LQDSQAKHKQLHREKDNFYKYKNAEQ----AKMQAKLRSSADEAILNASETR---AKRDDSGCLP 236
            ::.||.....|..::|....||..|:    |..|::||...|.||    ||.   .|...:...|
Human    28 MRSSQVSALGLEAQEDEDPSYKWREEHRLSATQQSELRDVCDYAI----ETMPSFPKEGSADVEP 88

  Fly   237 GVKSYNSKALSAADKVAKVAKGEAKTQRRAEEPVGEAEVEVEVEFRA---KREHNRLEGLSLSAA 298
            ..:|..::|....:....|.:..|..|.|...|         .|..|   :.||     |.::..
Human    89 NQESLVAEACDTPEHWEAVPQSLAGRQARTLAP---------PELWACPIQSEH-----LDMAPF 139

  Fly   299 SAQSGGSSESLQ-----TTTTSSSTPTTHSSVTSSTGRSGGRRKYSFKTHAGKSYHQHHHPSRRT 358
            |:..|...|.::     |:.|..|........||| ..||..|.||         ....||:...
Human   140 SSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSS-DNSGQTRYYS---------PCEEHPAETN 194

  Fly   359 SNMDSSNGGISMVAKLTHQFNEIIQKDAKLLE----QVKRNNGVWISRGTHVYKIVEKPTSEGKG 419
            .|..:.:|.|....:|.   :|.:|:...||.    ||....|            .::....|:|
Human   195 QNEGAESGTIRQGEELP---SEELQESQGLLHPQEVQVLEEQG------------QQEAGFRGEG 244

  Fly   420 LPNAD---DNRISTVQRNIKKFERL--EKPSVPLKSEQLMRKHLELMRGSSLSRGPRIKRNLKLP 479
            ....|   |..:...|    ..|::  ||.....|.||:.    ::|.|   .:|.|:       
Human   245 TLREDVCADGLLGEEQ----MIEQVNDEKGEQKQKQEQVQ----DVMLG---RQGERM------- 291

  Fly   480 PGSVGIPELAIVSEELKTPTSEEQAKKPKSVQNESQPNHPEELNQSNDKPSDELDLIMGEE---- 540
             |..|.||.....|       .||....:..|.:..|...||..:....|.:.......|:    
Human   292 -GLTGEPEGLNDGE-------WEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTF 348

  Fly   541 -GDEEELRQKQRKHKYASIYEKLRFTFAKGRKSASP---------SPTKAQIREEVSIDEE---- 591
             |..||:..||..|   .|.||  .....|:::..|         :..:|:.|||   :.|    
Human   349 LGKSEEVTGKQEDH---GIKEK--GVPVSGQEAKEPESWDGGRLGAVGRARSREE---ENEHHGP 405

  Fly   592 ------SIKDSTSEDMVTRKEDFTLDLP-KEVIPRAEDLEDSSHALLVSP--CFEADAKILDAL- 646
                  :.:||...|:..........:| .:...|||:|..::.:.|:.|  |......:|.:. 
Human   406 SMPALIAPEDSPHCDLFPGASYLVTQIPGTQTESRAEELSPAALSPLLEPIRCSHQPISLLGSFL 470

  Fly   647 --EAVDLKLKVLNPL 659
              |:.| |.|:|:.|
Human   471 TEESPD-KEKLLSVL 484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015
PH_ephexin 1805..1931 CDD:269929
SH3_ephexin1_like 1944..1998 CDD:212727
ARHGEF35NP_001003702.2 ARHGEF5_35 1..478 CDD:317795 115/527 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 139..418 73/337 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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