DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Exn and itsn2b

DIOPT Version :9

Sequence 1:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster
Sequence 2:XP_005158835.1 Gene:itsn2b / 445153 ZFINID:ZDB-GENE-050309-102 Length:1837 Species:Danio rerio


Alignment Length:1880 Identity:330/1880 - (17%)
Similarity:637/1880 - (33%) Gaps:595/1880 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   293 LSLSAASAQSGGSSESLQTTTT-----SSSTPTTHSSVTSSTGRSGGRRKYSFKTHAGKSYHQHH 352
            ||.|.:::..|.|:.|:..|::     |||:.::.|:..:|....||...:.....:...|.|  
Zfish   183 LSSSFSASPLGFSTTSMNKTSSLLDLGSSSSNSSPSTSLASNSPKGGPSDWGVPQASRLKYRQ-- 245

  Fly   353 HPSRRTSNMDSSNGG--------ISMVAKLTHQFN-------EIIQKDAK-----------LLEQ 391
                :.:::|....|        .:|...|..|..       ..:.||.|           |::.
Zfish   246 ----QFNSLDKLMSGYLTGPQVRTAMATTLLTQTQLAAIWNLADVDKDGKLKADEFILAMHLVDM 306

  Fly   392 VKRNNGVWISRGTHVYKIVEKPTSEGKGLPNADDNRISTVQRNIKKFERLEKPSVPLKSEQLMRK 456
            .|....:.::..:.:.    .|:..|| |..:.:....::...:.  |.|.:|..|.||.     
Zfish   307 AKMGQPLPLALPSDLV----PPSLRGK-LGESMNGTTPSIYAGLA--EDLCEPEPPQKSR----- 359

  Fly   457 HLELMRGSSLSRGPRIKRNLKLPPGSVGIPELAIVSEELKTPTSEEQAKKPKSVQNESQPNHPEE 521
                   ::|:...:.|:|::|  |:..:.:...|.:|.:....|.:|:|.:..|          
Zfish   360 -------NNLTFEDKFKKNMEL--GNAELEKRRQVLQEQQRREEERRAQKAREEQ---------- 405

  Fly   522 LNQSNDKPSDELDLIMGEEGDEEELR-QKQRKHKYASIYEKLRFTFAKGRKSASPSPTKAQIREE 585
              :..::.:.||:|   :...|||:| ::||:.:.....|:|:   ...||.|:    |.::..:
Zfish   406 --ERREREARELEL---KRKREEEIRLERQRELERQREEERLK---ELERKEAA----KKELERQ 458

  Fly   586 VSIDEE--------SIKDSTSEDMV-TRKEDFTLDLPKEVI-PRAEDLEDSSHALLVSPCFEADA 640
            ..::.|        :.|....||:: .|.:..:|::..|.: .:.:.:.|               
Zfish   459 QQLEWERRRKQELQNQKSEEQEDIIKLRAKKRSLEMELEAVGNKQKQISD--------------- 508

  Fly   641 KILDALEAVDL---KLKVLNPLND--VTTADGERELLLAANDDFEQRILPNSSFVYQAANKQYSN 700
            |:.||.....:   :|:::|...|  :|.....::.|    :||::::..::|...:..:|..|.
Zfish   509 KLRDAQGRKRIHKNELEMINQKRDSCITEISSLQKQL----EDFKRKLGQSTSEQQKLTDKLRSL 569

  Fly   701 NQILLNQAVNVTLVNAIEGEQM----------IMEQKQLMKVRDLELTERDIDQPLKRAEKSPEK 755
            :...:..|...||.|.:|.:.:          .:|::...|:.|::..::|| |.|:.:::.   
Zfish   570 SLNSVPTATVKTLQNNMEEKDLSCRKLKEQLNAVEKETAAKLADMDQYKKDI-QDLRESQRM--- 630

  Fly   756 DDTLEPESLYEPITPVMDETKTEAQTSSLFKIYTKKSELVEDIYQTVEEASTVEV-KPNNWLEGY 819
                 .||..|.:..:.:|        .:.::..:|.|.:|...:..||...::: |...|.|  
Zfish   631 -----QESALEKLRTIKEE--------KIRELKKRKQEELEKKRREEEEQKRIKLEKERQWQE-- 680

  Fly   820 ESIAGSQEACPLTYDGYESFAPEEVVTTPTTPSATGTLGRNTRDELPELPKPKRVLNKSPIPLRP 884
                                                   :..||   |..|.:::..:....||.
Zfish   681 ---------------------------------------KLRRD---EEEKQRKIQEERDAKLRE 703

  Fly   885 APPKPQ------AKESEEDENIYDTIKGCYESMHCKATSSSSSGEATLTTDTISLSSNCYESISH 943
            ...:.:      |||..|.|.              ||.....                       
Zfish   704 EEERERQARLQAAKEQAERER--------------KAREEEE----------------------- 731

  Fly   944 IRRSRVATTQNQGHGSAGSCIQLSSSGSTLTISSDHKTNSLYESSLAAAGCVVYGSASVGCRSSL 1008
             ||.|....:.:                      :.:...|.|                      
Zfish   732 -RRRREEEEERR----------------------EQERRRLEE---------------------- 751

  Fly  1009 GSSAGSRDSGKPGDKRSSIAGSSDNSDAWVDISDGEIGQATTDATANEAQFIVVRERFKPHRTRS 1073
                  .|..:..::|..:.......:        |..:...|....:.:..:..||.:..|.|:
Zfish   752 ------EDRRRRDEERRKLEEERRKLE--------EERRKLEDERKRQEEIRLKEEREREERRRA 802

  Fly  1074 PDWSKRIRDKRLQQKKAISCIEDDSDHYYETLSPLGNKRHSTQ--LVRQSQDGNRSGGVRSSHRR 1136
            .:..:|..::|.::::.....|::            .:||..|  .:|.:::..|   :....:|
Zfish   803 EEERRRKEEERREEERKREREEEE------------RRRHRAQEAAMRDAEERKR---IEEERKR 852

  Fly  1137 SKNHSASAHTLGEHVVISDDYDSFETDSDDHGDGEPDLRQRNYNDSGVDMRNHRLPKPPPPQNQV 1201
            .                         :.:.....|.|.|:|.......|....|      .|.|.
Zfish   853 K-------------------------EEERRKQEEEDRRRREEEQRKQDEERKR------KQQQE 886

  Fly  1202 YEFVRKFKDFISSKKSP----------------KGSQQKL---YENTPASTLF---YVECSKRTE 1244
            .....:.:|...:||:.                ||.::.|   :..:.|.|.|   |...::..|
Zfish   887 EAAAARLRDDEQNKKNTVKSDLVSALLRGLEERKGGRRPLGTQHRRSAALTTFKALYPFTARNEE 951

  Fly  1245 DV-YENTD---------------FG---------PERIPAPETKGPVHQEQAPVLRAKQ--KNGK 1282
            :: :|:.|               :|         ||.....:||     .:|||: |||  |...
Zfish   952 ELSFESDDLIEVDESVEREQGWLYGSWQGKMGWFPESYVEKQTK-----SEAPVV-AKQALKPQV 1010

  Fly  1283 SLR-SRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPE----GSLPALPL---------------- 1326
            |:. |:|.....||..:    |:..||.:|.......    |::.|..|                
Zfish  1011 SISVSKLSDGPGGSRLN----SAFTPTHATGSTSSNHGQVVGNVQAQALCSWSAKTDNHLDFSKD 1071

  Fly  1327 -------EPEIHGSGELD--SGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPP 1382
                   :.|....||||  .|:..|....:..|......:..|......:.....:.|...:.|
Zfish  1072 DVITVLEQQENWWLGELDGVQGWFPKTYVTVLSTSDAQADSTDASDTTDGSNYEEYVALYTYESP 1136

  Fly  1383 PPPPPMTGNKSPLDPERELDAEQTTSWYA-----ECGVF-----------------KQATNG--- 1422
            .|     |:.:..:.:..|.:|:...|:.     ..|:|                 |..|.|   
Zfish  1137 EP-----GDLTFNEGDTILVSEREGEWWRGSIGDRAGLFPSNYVKPKETDTSSLSGKSGTPGKKP 1196

  Fly  1423 -------AVSPRGDEPVTPTPSG-----HGGVSSWY----------AESGLYQTSGISVASSSGS 1465
                   |.:..|.|.:..:|..     :...|.|:          .:.|.:..|.:.:..|  :
Zfish  1197 EVAQVTTACTAAGAEQLNLSPGQLILILNKNPSGWWLGELQARGKKRQKGWFPASHVKLLGS--N 1259

  Fly  1466 SGVSTGNEAGLGDELSSEPHSLFSNEPLYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPE 1530
            ||.||.....:|..::           :|. |:||..:.:        |....:.|.:..|:.|:
Zfish  1260 SGKSTPATPSVGQVIA-----------IYD-YTAANEDEL--------SFSKSQVINVLDKSNPD 1304

  Fly  1531 ----------PLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIIT 1585
                      .|:   ||....:...:.||:. |......:.|     ::.::|..|:...|:|.
Zfish  1305 WWKGELNGVTGLI---PTNYVKLTTDSDPSQQ-WCADQSTLES-----MSPKDRKRQDYIHELID 1360

  Fly  1586 SEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLL 1650
            :|..|::.|.|:...|  :....:|:.||..:...:|:....:.:||.::|..|:|..:..    
Zfish  1361 TEEKYVEDLQLVLEVF--YKPMSESNRLSEAEMNMIFANWRELIQCSSKMLKALKARKKSG---- 1419

  Fly  1651 GLSRCIYEIAE------RHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGL 1709
            |.:..::.|.:      .:...|:.||..|......|::..:.:..  |:..|:::.....|.|:
Zfish  1420 GDNMPVHMIGDILTSELSNMQAYIRFCSCQLEGAALLQQRTDQEPD--FKTFLKKIATDYRCKGM 1482

  Fly  1710 NLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFEL 1774
            .|.|||:.|||||||.||.|..:. :.:|.:..:|......|...:.:..:.||.....|.:..|
Zfish  1483 PLSSFLLKPMQRITRYPLHIKHIL-ENTPESHVDYIQLTEALEKAELLCFEVNEGVREKENSDRL 1546

  Fly  1775 ERIARQLEFPSHVRALAIAP----------VGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGK 1829
            |.|      .|||:...||.          :|       ||         .||..|:..|:...|
Zfish  1547 EWI------QSHVQCEGIAENLIFNSMTNCLG-------PR---------KLLHSGKVFKMKSNK 1589

  Fly  1830 RLTKISIYAFLFSDLLLLCKRRGESCFSVFD--YCPRS-------MLTLAAGDSLPQLPTKDLKD 1885
            .|     :||||||.||..:...:...|..|  :.|:|       ...:...:.|.:||:....|
Zfish  1590 EL-----HAFLFSDFLLFTQAVRQFTSSGTDKLFSPKSNTQYKMYKTPVFLNEVLVKLPSDPSSD 1649

  Fly  1886 QAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPP-----EAE-TPGEKLYES 1939
            :.      :..:.:.||   ...|...:::::..|:|.::..     |.| ...||.|:|
Zfish  1650 EP------VFHISHIDR---VYTLKTENINERTAWVQKIKVASEGFIETEKKKHEKAYQS 1700

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 44/187 (24%)
PH_ephexin 1805..1931 CDD:269929 30/140 (21%)
SH3_ephexin1_like 1944..1998 CDD:212727
itsn2bXP_005158835.1 EH 7..99 CDD:197477
EH 19..83 CDD:238009
Amelogenin <80..183 CDD:197891 330/1880 (18%)
EH 232..327 CDD:197477 13/104 (13%)
EH 243..308 CDD:238009 11/70 (16%)
TAF4 <453..592 CDD:296797 26/157 (17%)
DUF4349 <559..691 CDD:305044 30/192 (16%)
SH3 936..992 CDD:302595 9/55 (16%)
SH3 1051..1102 CDD:302595 9/50 (18%)
SH3_Intersectin_3 1126..1177 CDD:212772 9/55 (16%)
SH3_Intersectin2_4 1198..1256 CDD:212927 8/57 (14%)
SH3_Intersectin2_5 1271..1324 CDD:212929 12/75 (16%)
RhoGEF 1355..1535 CDD:279015 44/188 (23%)
PH_ITSN 1562..1692 CDD:270084 32/159 (20%)
PH 1576..1684 CDD:278594 27/121 (22%)
C2_Intersectin 1695..1829 CDD:176021 4/6 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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