Protein Alignment Exn and Arhgef15

DIOPT Version :10

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: XP_011247414.1
• Gene: Arhgef15 / 442801
• MGIID: 3045246
• Length: 877
• Species: Mus musculus
• Alignment Length: 812
• Identity: 212/812 - (26%)
• Similarity: 315/812 - (38%)
• Gaps: 226/812 - (27%)

  Fly  1254 PERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPE 1318
            |.|..||.:.||:|...:|                 |:|...|.|    :|.:...|.|: |.|.
Mouse    25 PSRHRAPHSPGPLHNGSSP-----------------KALPQISND----ASASVCTSIFW-EPPT 67

  Fly  1319 GSL--PALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDP 1381
            .||  ||| |.|.:..: .|||..|..:.:   .||..|.|:|::.....|          |..|
Mouse    68 ASLKPPAL-LPPSVSRT-SLDSQTSPDSPS---STPSPSPVSRRSISPEPA----------PCSP 117

  Fly  1382 PPPPPPMTGNKSPL--DPERELDAEQTT-----------SWYAE-----CGVFKQATNGAVSPRG 1428
            .|||.|...:::||  .|....|...:.           .|.||     ....::.:.|:....|
Mouse   118 VPPPKPSGSSRTPLPSGPTPLQDGSASAPGTVRRLAGKFEWGAEGKAQSSDSLERCSQGSTEVNG 182

  Fly  1429 DEPVTPTP--SGHGGVSSWYAESGL----------------YQTSGISVASSS------------ 1463
             |..||..  ||:|...:...::.|                .:...:.|.||.
Mouse   183 -EKETPEAALSGNGSQENGTPDAALACPPCCPCVCHVAKPGLELRWVPVGSSEDILRIPCRASPL 246

  Fly  1464 ------------------------------------------------------------GSSGV 1468
                                                                        ...|:
Mouse   247 RASRSRINPPVISHPPVVLTSYRSTAERKLLPPLKPPKPTKVRQDISTSEELPQPDLKLPSEDGI 311

  Fly  1469 STGNEAGLGDE-----LSSEPHSL-------------------FSNEPLYQMYSAAKLESITRDL 1509
            .|..:|..||.     |::.|.:|                   ..:|||||.|.||.|.
Mouse   312 QTATKAWEGDRPEGAPLNAPPVALEGREEEGLDGLKGLQWELPLQDEPLYQTYRAAVLS------ 370

  Fly  1510 EAHGSSDGYEEI-GLQAKAKPEPLVKP--RPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTS 1571
                     ||: |:.....|.| ..|  .||..:|..|:|    |||.|:|.|..|.:|.:|:.
Mouse   371 ---------EELWGVGEDGGPSP-ANPGEAPTFSRLPGPRN----TLWQELPAVRGSGLLESLSP 421

  Fly  1572 RERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLL 1636
            :||.:||:.||::|||||||:||.||...|:...|..|:  |:.:|...|||.:..|...|||.|
Mouse   422 QERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDT--LTPRDHHTLFSNVQRVQSVSERFL 484

  Fly  1637 TELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLE 1701
            ..|.:..:.:..:..|...::..|...|.|||.:..:|...:.|..||.::  ::.|...|.||:
Mouse   485 GTLLSRVRSSPHITDLCDVVHAHAVGPFFVYVDYVRNQQYQEETYSRLMDT--NVRFSAELRRLQ 547

  Fly  1702 ASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSK-ESPLNREEYESWKLTLALVQKVVGQCNEAA 1765
            :.|.|..|.|.|||:||.||||||.:|:..:.|: |...:|:  |:.:..|..|.|::.:|:...
Mouse   548 SLPKCERLPLPSFLLLPFQRITRLRMLLQNILSQTEEGSSRQ--ENAQKALGAVSKIIERCSAEV 610

  Fly  1766 NRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKR 1830
            .|.:|..||.|:.::|.| ..|:||.:.        :..|.|..:||||.|..|......|...|
Mouse   611 GRMKQTEELIRLTQRLRF-HKVKALPLV--------SWSRRLELQGELTELGCRRGGVLFTSRPR 666

  Fly  1831 LTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMT 1895
            .|.:.:  .|||||||:.:.:......|.||..||::      ...|:|     |.:|.....::
Mouse   667 FTPLCL--LLFSDLLLITQPKSGQRLQVLDYAHRSLV------QAQQVP-----DPSGPPTFRLS 718

  Fly  1896 LLENCDRKTVELVLSCPSVSDQQRWLQAMRPP 1927
            ||.|...:....:|...|:|...|  ..|.||
Mouse   719 LLSNHQGRPTHRLLQAASLSVSLR--PTMNPP 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1762	CDD:459876	64/181 (35%)
		PH_ephexin	1805..1931	CDD:269929	37/123 (30%)
		SH3_ephexin1_like	1944..1998	CDD:212727
Arhgef15	XP_011247414.1	RhoGEF	430..606	CDD:214619	64/181 (35%)
		PH_ephexin	630..750	CDD:269929	40/142 (28%)