DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and PLEKHG7

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_001364258.1	Gene:	PLEKHG7 / 440107	HGNCID:	33829	Length:	691	Species:	Homo sapiens

Alignment Length:	675	Identity:	147/675 - (21%)
Similarity:	238/675 - (35%)	Gaps:	179/675 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1248 ENTD-FGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLRS----------------RLRKSLVGS 1295
            |.|: |.|| :| |:..|   ....|.||:..||..||..                |||....|:
Human     2 EKTESFCPE-VP-PQDCG---ASPRPSLRSLPKNQGSLLQFDRQAPGRISTSPTLRRLRTRGCGT 61

  Fly  1296 SFDTKQLSSL----APTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFST 1356
            ..|..|:::.    ||.....|:..   |||..|.:             |....:||....:.::
Human    62 RQDAWQVTTWGSWGAPVGFPCYLSK---SLPGSPKD-------------SSHLLSPLRLHSRLTS 110

  Fly  1357 VARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATN 1421
            ...:|...|.:...:|    ||.|...||        .|.|..|....|.:....|.......|.
Human   111 EPERALNAADSLEPQT----RPTDKYLPP--------ELQPVNEGSLHQASLRQQEGHFLPSPTL 163

  Fly  1422 GAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHS 1486
            ...||:|:| :.|              |..|:....||..:      ..|.|...||.|.|:..:
Human   164 RHPSPQGEE-LHP--------------SRFYEHRRSSVVLN------LPGLEVFPGDLLVSDGAA 207

  Fly  1487 LFSNEPLYQMYSAAK-------LESITRDLEAH-------------GSSDGYEEIGLQAKAKPEP 1531
            .:...||..:.|.:|       ...:.:|...|             .|..||:..||:.|.
Human   208 DYLCHPLLLLNSESKKPRWPFSKRGVGKDKHKHISDLENCLSSVKITSFRGYDFYGLKDKT---- 268

  Fly  1532 LVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASY-LKSLN 1595
                                  |.|:.|..|.  |||.....:..|||.:|:.|||.:| |..|.
Human   269 ----------------------WDEVLETHHK--LPTDQLDLKKQQEAVWELFTSECTYFLDHLL 309

  Fly  1596 LLRRHFMNHNAFLDS-SVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCI--Y 1657
            :|:..|||...:|.: ..|...|...||:.:..:.:.|...:..|....:|.:....:|..:  .
Human   310 VLKMIFMNTLRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFI 374

  Fly  1658 EIAERHF-----HVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLML 1717
            .:..::|     ..:..:|.:.......|..|::..:   |..:|:..|.:..|..|::...|:.
Human   375 SVLTKYFRGSLCQSHQTYCLNYSAAIFYLESLRQRDD---FGIYLKWCEQNEQCRRLHVPELLVA 436

  Fly  1718 PMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQL- 1781
            |:||:||.|||:..:: |.|..:.|:...:.:. ..|:|.:... |...:|...|:..|..:::
Human   437 PLQRLTRYPLLLKNIW-KRSMDSAEKIMIYSIK-EKVEKSIRDL-EGKVKWLDNFQKFRYLQEII 498

  Fly  1782 --------------------EFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLT 1826
                                .|..|:....::|..                 .|||:.|   |||
Human   499 VWPPLWDRDKRFFIPECLKHIFKEHMAENILSPTS-----------------RHLLYEG---KLT 543

  Fly  1827 FGKRLTKISIYAFLFSDLLLLCKRR 1851
            ..:....:.:|.|||:|.||:.|.:
Human   544 LAESTRFLDVYLFLFNDFLLVTKTK 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	43/190 (23%)
		PH_ephexin	1805..1931	CDD:269929	15/47 (32%)
		SH3_ephexin1_like	1944..1998	CDD:212727
PLEKHG7	NP_001364258.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		15/50 (30%)
		DUF4675	2..178	CDD:406211	51/223 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..140		9/42 (21%)
		RhoGEF	292..476	CDD:214619	44/188 (23%)
		PH_PLEKHG7	535..663	CDD:270065	15/37 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810