DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Exn and trio

DIOPT Version :9

Sequence 1:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster
Sequence 2:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster


Alignment Length:2342 Identity:422/2342 - (18%)
Similarity:738/2342 - (31%) Gaps:824/2342 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 VNSDSENNNRATCDKAGKDNPNPNQNPNSQANPNQN----------CSCESRAFRDFR----GVQ 108
            :|:.:....:|..:..|.|..:...:...|:.|:|.          .:..::|.|...    |.:
  Fly   232 INAMAPPGGQAPTNSGGPDMDSGPSSAGQQSQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQE 296

  Fly   109 TLRLLWSRRIKSASEDQC------------------HSPVHCHTSSSSLGTLKKLNKSV-----S 150
            .|.:||..  |....|||                  |:......|...:|....:.||:     .
  Fly   297 KLLMLWQH--KKVKLDQCFQWRLFEQDCEKMFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQK 359

  Fly   151 CLVNAFNNSRDCATPEKTLAKRAASLHNLQDSQAKH-KQLHREKDNFYKYKNAEQAKMQAKLRSS 214
            ..|.:.|.|   ...::.||. ||.|...|...|:| |.|.:..|..:|           ...:.
  Fly   360 FAVASMNVS---VNIDRILAV-AARLIESQHYAAQHIKTLAQRLDRTWK-----------DFAAG 409

  Fly   215 ADE--AILNASETRAKRDDSGCLPGVKSYNSKALSAADKVAKVAKGEAKTQRRAEEPVGEAEVEV 277
            .||  |:|..|.....:.:..|       ||           ||...|..|  |.:|:......:
  Fly   410 LDERTAVLQLSVLFHHKAEQYC-------NS-----------VASWAAACQ--ASQPLPSDIQSL 454

  Fly   278 EVEFRAKREHNRLEGLSLSAASAQSGGSSESLQTTTTSSSTPTTHSSVTSSTGRSGGRRKYSFK- 341
            |...|..:        ||..|..|:                   ::.|.|::      :|..:: 
  Fly   455 ETAIRTHQ--------SLYEAMCQA-------------------YTEVHSTS------KKLLYQL 486

  Fly   342 THAGKSYHQHHHPS----RRTSNMDSSN------------GGISMVAKLTHQF------------ 378
            .|..:..:|...|.    |:.||..|.|            .|.|.|..:.||.            
  Fly   487 DHLVQVCNQPPPPGVPDHRKNSNNGSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKWH 551

  Fly   379 -----------NEIIQKDAK-LLEQVKRNNGVWISRGTHVYKIVEK----PTSEGKGLPNADDNR 427
                       ..:.|:|.| :|:.:|.:..|::.:.|.:.:...|    .||. ....|...|.
  Fly   552 QERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFLRKNTGIGRNFHKARVYQTSH-DNFENVAQNT 615

  Fly   428 ISTVQRNIKKFERLEKPSVPLKSE-QLMRKHLELMRGSSLSRGPRIKRNLKLPPGSVGIPELAIV 491
            .|..|:.:...:.|.:......:| ..:.:.|||..||...|..:.:|.|          ::|::
  Fly   616 YSNAQKLLAAADELARSGEADPNEIYSVARELELQVGSFAERVEQRRRRL----------DMAVI 670

  Fly   492 -----------SEELKTPTSEEQAKKPKSVQNESQPNHPEELNQSNDKPSDELDLIMGEEGDEEE 545
                       .::|:|..|.::.:                |:|.|            .||.|..
  Fly   671 FYTHEKDVTAWIDKLRTDVSTDETR----------------LSQEN------------LEGIERI 707

  Fly   546 LRQKQRKHKYASI----------------YEKLRFTFAKGRKSASPSPTKAQIREEVSIDEESIK 594
            |:|.||..:.:|:                ...|.:....|..:|..:..:...:::|.::|....
  Fly   708 LQQYQRDQQESSVNVCLTTISQGEALLQEMRSLEYADNTGSIAALEATLEKLNKQKVELEELWSA 772

  Fly   595 DSTSEDMVTRKEDFTLD---LPKEVIPRAEDLEDSSHALLVSPCFEADAKILDALEAV------- 649
            .....|::.|...|..|   |..::...:|:|:   ||.|.....:|:..|....|:|       
  Fly   773 RKFRADLILRLRYFERDARLLSVQMEMWSEELQ---HADLSRDYQKAEQLIRMHNESVTEIQNAT 834

  Fly   650 --------DLKLKVLNPLNDVTTADG----------------ERELLLAANDDFEQRILPNSSFV 690
                    || |::......::.||.                |||:      |.|:......:.:
  Fly   835 YEVVQQGQDL-LQLFENAGFISMADATHTAQARIEYLLDFLREREI------DLEEMSEAKRAKL 892

  Fly   691 YQAANK-QYSNNQILLNQAVN------VTLVNAIEGEQMIMEQKQLMKVRD-----LELTERDID 743
            .||... |:.|:   .||.::      ..||.:......:.|.:||.|..:     :|.|.....
  Fly   893 EQAVQLCQFQND---ANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSAV 954

  Fly   744 QPLKRAEKSPEKDDTLEPESLYEPITPVMDETKTEA--QTSSLFKIYTKKSELVE---DIYQTVE 803
            |...||       |.|...:.|:|::  :||...:.  :...|.....::.:||.   :.|:|.|
  Fly   955 QVKYRA-------DALINANHYDPLS--IDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAE 1010

  Fly   804 EASTV------EVK-PNNWLEG----------YESIAGSQE-------ACPL---TYDGYESFAP 841
            :..:|      |.| .::|.:|          .:.|:..||       ||.|   |.:.:..:|.
  Fly  1011 QVCSVLDSLEREYKREDDWCDGGGGSDKAQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYAN 1075

  Fly   842 EEVVTTPTTPSATGTLGRNTRDELPELPKPKRVLNKSPIPLRPAPPKPQAKESEEDENIYDTIKG 906
            ..........:..|.: ::..|:|  |.:..:||:...:      .|....:.::......:.|.
  Fly  1076 RSQQCYQYKGNCEGHV-KSKLDKL--LTQENQVLDYWTL------RKKSLDQCQQFVLFERSAKQ 1131

  Fly   907 CYESMHCKATSSSSSGEATLT------------TDTISLSSNCYESISHIRRSRVATTQNQGHGS 959
            ..|.:|       ::|||.|:            |:.:....|.:.|.:...|.||..        
  Fly  1132 AIEWIH-------NTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKL-------- 1181

  Fly   960 AGSCIQLSSSGSTLTISSDHKTNSLYESSLAAAGCVVYGSASVGCR----------------SSL 1008
               .|||:              :||.|...|.|..:....|||..|                .||
  Fly  1182 ---LIQLA--------------DSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSL 1229

  Fly  1009 GSSAGSRDSGKPGDKRSSIAGSSDNSDAWVDISDGEIGQATTDAT-------ANEAQFIVVRERF 1066
            |.|......|..|:  |||:.||              |...:|.|       :|:....:..|:.
  Fly  1230 GMSQQQLLLGSDGN--SSISSSS--------------GDRHSDPTLEAKLNSSNKENKEINEEKR 1278

  Fly  1067 KPHRTRSPDWSKRIRDKRLQQKKAISCIEDDSDHYYETLSPLGNKRHSTQLVRQSQDGNRSGGVR 1131
            |..|.:....::.::.:|.......:||:...:.:      ...|...:.|:  .|:....|.::
  Fly  1279 KSARRKEFIMAELMQTERAYVNDLATCIKCFLEEF------RAGKSVPSALI--GQEDVIFGNIK 1335

  Fly  1132 SSH--------RRSKNHSASAHTLGE-HVVISDDYDSF-------ETDSD---DHGDGEPDLRQR 1177
            ..|        |..:.:......:|. .|..:..:|.:       .|.::   .||....:..||
  Fly  1336 EIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGGSFFEELQR 1400

  Fly  1178 NYNDSGVDMRNHRLP----KPPPPQNQVYEFVRKFKDFIS-------------------SKKSPK 1219
            ...   ||   |.||    |   |..::.::....||.:|                   .||:..
  Fly  1401 RLE---VD---HPLPAYLIK---PVQRITKYQLLLKDLLSCCEESHGEIKEGLEVMLNVPKKAND 1456

  Fly  1220 GSQQKLYENTPAST------------------------------------LFYVECSKRTEDVYE 1248
            .....|.||...|.                                    ||..|..:.....|:
  Fly  1457 AMHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKESNVVKYQ 1521

  Fly  1249 ------NTDFG-PERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLA 1306
                  .||.| .|.|...|||..|...::|:|           |..|..|..:|.:|||: .:.
  Fly  1522 FKSKLMTTDMGITEHIEGDETKFAVWTGRSPML-----------SDCRIVLKATSLETKQI-WVK 1574

  Fly  1307 PTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRR 1371
            ..|.........|:...||..|..|      ||.|.::...|.|.                    
  Fly  1575 KLREVMQETCFSGTSLTLPKSPAKH------SGSSQRSSRDLDEQ-------------------- 1613

  Fly  1372 TTIGLRPNDPPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGA------------- 1423
                |..||.........|:.:..|.:.:|..::.| |.....:   ||:|:             
  Fly  1614 ----LTENDHDRCSLASFGSGNTTDSDNKLGNQEAT-WVVADYI---ATSGSNELSVSKGQQVEI 1670

  Fly  1424 ---------------VSPRGDE--------PVT---PTPSGH---GGVSSWYAESGLYQTSGI-- 1457
                           ::|:.|:        ||:   |.|..|   .|.::..|.|...|.|.:  
  Fly  1671 VEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQD 1735

  Fly  1458 --------SVASS------SGSSGVSTGNEAGLGDELSSEP---------------HSLFSNEPL 1493
                    :::||      ||.:.:...|..|.....||:|               |:....|..
  Fly  1736 QSNRSKADALSSSTKRRGFSGRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQ 1800

  Fly  1494 YQMYSA--------AKLESITRDLEAHGSSDGY---EEIGLQAKAKPEPLVKPR-----PTAL-- 1540
            .|...|        ::..|.|:.....|:.| |   ||:||:.....:|:.:|.     |.|.  
  Fly  1801 NQQPGASPATVLPSSQFPSSTQHPGGAGAGD-YEPDEEVGLELPPPMKPIQEPHLIANGPPAFAK 1864

  Fly  1541 -------QLVEPKNGPSRTLWSEIPEVI------------------------------------- 1561
                   .:..|.......| |||.|::                                     
  Fly  1865 DAKESSGNMASPGKMDGNPL-SEIEEIVKTTTEQHESNSRVDGGGGVENASTNGHGRSHDNNDES 1928

  Fly  1562 HSCILPTLTSRERSLQEAK---FEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKD-----R 1618
            |:.:    :.:..:|::.:   .|::::|.:|::.|:.:...:|......:|.:...:|     .
  Fly  1929 HTAV----SDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKM 1989

  Fly  1619 KALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRC---------IYEIAERHFHVYVAFCEHQ 1674
            |.:|:.|..::|            |..:..|..|..|         :.:.:...|.:|..:|.: 
  Fly  1990 KLVFNNIKDIYE------------WHRDFFLRALRNCQKSPADLGPLIKRSATKFALYYTYCSN- 2041

  Fly  1675 GRMDRTLRRLKESKESLAFQQHLERLEASPSCCG--LNLHSFLMLPMQRITRLPLLIDAVFS--- 1734
                      |...|.:. ..|.:..::.....|  |:|.:.::.|:||||:..|||..:..   
  Fly  2042 ----------KPLSEYIV-SAHYQYFDSIRQKLGHRLDLSNLIIKPVQRITKYELLIKEIIKATE 2095

  Fly  1735 -----KESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQL-EFPSHVRA---- 1789
                 ||.|:.:|.|:..|:.:..|.                 ::..:.|.| :|...:.|    
  Fly  2096 GAGLYKEVPMLQEAYQQMKVVVKTVN-----------------DMMVVLRSLQDFDGEITAQGSL 2143

  Fly  1790 LAIAPVG-VPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLC---KR 1850
            |...|:. |..|..|.|                             .:..|||..:::..   |.
  Fly  2144 LMQGPMNCVVDAAQKHR-----------------------------ELQVFLFQQIIIFADIEKT 2179

  Fly  1851 RGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVS 1915
            :.:....:|.|  ||.:      .|..:..|:|.|       ....:.:.|.|..|:.:.|.:.|
  Fly  2180 KNQYASPIFKY--RSHI------QLNHMQMKELGD-------CRFQIRSTDPKIPEMTIICQAAS 2229

  Fly  1916 DQ 1917
            .:
  Fly  2230 QE 2231

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 39/205 (19%)
PH_ephexin 1805..1931 CDD:269929 18/116 (16%)
SH3_ephexin1_like 1944..1998 CDD:212727
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103 38/196 (19%)
SPEC 563..778 CDD:238103 44/253 (17%)
SPEC 782..997 CDD:238103 47/236 (20%)
SPEC 897..1119 CDD:238103 47/242 (19%)
SPEC 1125..1226 CDD:197544 25/132 (19%)
RhoGEF 1287..1456 CDD:279015 29/185 (16%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 27/133 (20%)
PH 1495..1580 CDD:278594 23/96 (24%)
SH3_Kalirin_1 1643..1707 CDD:212786 9/67 (13%)
RhoGEF 1945..2122 CDD:279015 39/217 (18%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 26/146 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 00.000 Not matched by this tool.
11.030

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