Protein Alignment Exn and cindr

DIOPT Version :10

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_001263129.1
• Gene: cindr / 43654
• FlyBaseID: FBgn0027598
• Length: 941
• Species: Drosophila melanogaster
• Alignment Length: 925
• Identity: 164/925 - (17%)
• Similarity: 282/925 - (30%)
• Gaps: 344/925 - (37%)

  Fly   752 SPEKDDTLEPESLYEPITPVMDETKTEAQTSSLFKIYTKKSELVEDIYQTVEEASTVEVKPNNWL 816
            :|:.||.||.:                                |:||...:    :.|:....|.
  Fly   265 APQNDDELELK--------------------------------VDDIIAVI----STELPDKGWW 293

  Fly   817 EGYESIAGSQEACPLTYDGY-ESFAPEEVVTTPTTPSATGTLGRNTRDELPELPKPKRVLNKSPI 880
            :|  .|.|.....|   |.: :..||.|....|                              |:
  Fly   294 KG--EIRGKVGVFP---DNFVKMLAPSEATAAP------------------------------PL 323

  Fly   881 PLRPAP---PKPQAKESEEDENIYDTIK--------GCYESMHCKATS--------SSSSGEATL 926
            | ||.|   |......:.....|.|.::        |.:|.:..:..|        .:....||.
  Fly   324 P-RPRPRTRPGMGGTGAGSGSGIIDGVRTPRRTQRGGSFEFLGARMASFITTIFAPINEPPSATQ 387

  Fly   927 TTDTISLSSNCYESISHIRRSRVATTQNQGHGSAGSCI------QLSSSGSTLTISSDHKTNSLY 985
            .|......||...:.||:      ||.|..:.|..|..      |:..|.||.:.....||.|
  Fly   388 ITQNQRKVSNTASTTSHM------TTTNSSNSSTTSVTTQQQKEQIGGSSSTTSKVYIKKTGS-- 444

  Fly   986 ESSLAAAGCVVYGSASVGCRSSLGSSAGSRDSGKPGDKRSSIAGSSDNSDAWVDISD--GEIGQA 1048
             ||.:........|:|.|.:.|.    |||||                      ::|  .|.|..
  Fly   445 -SSNSTTSSTTTASSSAGRKESF----GSRDS----------------------LNDILSETGLP 482

  Fly  1049 TTDATANEAQFIVVRERFKPHRTRSPDWSKRIRDKRLQQKK------AISCIEDDSDHYYETLSP 1107
            |.:..|..                     |.:.:|.|...|      ::|
  Fly   483 TGNVAAQR---------------------KSLENKNLDLTKPPGVGASVS--------------- 511

  Fly  1108 LGNKRHSTQLVRQSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSFETDSDDHGDGEP 1172
            :|.:|.||                     |...::||.|:...:..|....|.|
  Fly   512 IGQQRSST---------------------SSATTSSATTVATGLTSSSVSKSME----------- 544

  Fly  1173 DLRQRNYNDSGVDMRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPK----------GSQQKLYE 1227
                        :|.:.::..||||       |...|..:..||:|.          |.::|..|
  Fly   545 ------------NMLDEKVKSPPPP-------VLSKKPSVPLKKTPTGGVPMTGNLLGGKKKNTE 590

  Fly  1228 NTPASTLFY-----VECSKRTEDVYENTDFGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSR 1287
            ....:.:.:     :..||...        |..::|.....|.|...:|..:..:.
  Fly   591 GKLTTAVSHDLADGLAASKMLS--------GANQLPESGAAGNVVIRRAATIAVED--------- 638

  Fly  1288 LRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPL---------EPEIHGSGELDSGFSDK 1343
                   :.||..:.:|:........|:.|:...|:..:         ...::|||...||.:..
  Fly   639 -------TDFDRVERASILTDMRQGRVKAPKRRPPSAAINVLGESNNNSVYVNGSGMSGSGGAGS 696

  Fly  1344 NCTPLPETPKFSTVARKAKKEAKANRRRT---TIGLRPNDPPPPPPPMTGNKSPLDPERELDAEQ 1405
                          |.:..::..|..:.:   :.|..|....|.|......|:|.  ..||.|.|
  Fly   697 --------------ASELSEDGGAGGKTSDDNSTGEEPQLAKPKPREWEKKKAPW--MEELKASQ 745

  Fly  1406 TTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVST 1470
            .|         ::.|:.:|.|||......|       |..:|......::..|:.:...||.|::
  Fly   746 VT---------RKKTSPSVEPRGASVAERT-------SKLFAAEQAVSSNSSSITTKVQSSAVTS 794

  Fly  1471 G----NEAGLGDELSSEPHSLFSNEPLYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEP 1531
            .    |.......::|..|:..::..:.:..||||:::.:.|.|...:..  ..:.::.:....|
  Fly   795 SMFVENSTTSSSVITSSSHTTTNDAIMSRSLSAAKVQTASSDEETRATRP--NSLAIRNQRSVSP 857

  Fly  1532 LVK-----------PRPTALQLVEPKNGPSRTLWSEIPEV------IHSCILPTLTSRERSLQEA 1579
            |||           .:||: ||...::..|    |.:.::      :...:|    :::|:::|.
  Fly   858 LVKSSNASSSQSQEEKPTS-QLNNHQDASS----SRVAQLEQRVDKLEGLVL----NQQRTIEEL 913

  Fly  1580 KFEIITSEASYLKSL 1594
             ...:.|||..:|.|
  Fly   914 -VNALKSEAERVKIL 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1762	CDD:459876	5/14 (36%)
		PH_ephexin	1805..1931	CDD:269929
		SH3_ephexin1_like	1944..1998	CDD:212727
cindr	NP_001263129.1	SH3_CD2AP-like_1	6..60	CDD:212806
		SH3_CD2AP-like_2	97..149	CDD:212807
		SH3_CD2AP-like_3	258..310	CDD:212808	15/85 (18%)