DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and arhgef18a

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_999983.1	Gene:	arhgef18a / 407987	ZFINID:	ZDB-GENE-040516-14	Length:	940	Species:	Danio rerio

Alignment Length:	1085	Identity:	207/1085 - (19%)
Similarity:	344/1085 - (31%)	Gaps:	417/1085 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 SEDQCHSPVHCHTSSSSLGTLKKLNKSVSCLVNAFNNSRDCATPEKTLA--------------KR 172
            |.|:||..|              |...:.      :::||...|..:||              ||
Zfish    27 SIDECHYNV--------------LRDDLE------SDARDFEAPTWSLAVDPQYLKNFSKDAVKR 71

  Fly   173 AASLHNLQDSQAKHKQLHREKDNFYKYKNAEQAKMQAKLRSSADEAILNASETRAKRDDSGCLPG 237
            ...:|.|..::..|.:..:...|.|          ..:||::     |...|||.:|    ..|.
Zfish    72 QDVIHELIQTEINHVRTLKIVLNVY----------IRELRNT-----LQMDETRLER----LFPQ 117

  Fly   238 VKSYNSKALSAADKVAKVAKGEAKTQRRAEEPVGEAEVEVEVEFRAKREHNRLEGLSLSAASAQS 302
            |::.                                 :||...|        |:.|.|....:..
Zfish   118 VENL---------------------------------LEVHQFF--------LDNLKLRRLDSME 141

  Fly   303 GGSSESLQTTTTSSSTPTTHS----SVTSSTGRSGGRRKY------SFKTHAGKSYHQHHHPSRR 357
            .|||::.          ..|:    .:|..:|..|.|.:|      |..|.|...|......:::
Zfish   142 PGSSQNY----------CIHNLGDILITQFSGEIGSRLRYLYGMFCSRHTDAVNFYKDLMQNNKK 196

  Fly   358 TSNMDSSNGGISMVAKLTHQFNEIIQKDAKLLEQVKRNNGVWISRGTHVYKIVEKPTSEGKGLPN 422
            ..|:......:|:|.:|  ...|||    .|:.|......|...|   |.|..|..:.|...|..
Zfish   197 FQNLIRKICQLSIVRRL--GIPEII----LLITQRITKYPVLFER---VIKYTEDESEEQMDLIK 252

  Fly   423 ADD---NRISTVQRNIKKFE----------RLE-KPSVPLKSEQLMRKHLELMRG---------- 463
            ..|   :.|:.|..::.:.|          :|| |..|.:.|.::.|:. ::::|
Zfish   253 GPDFLKDTIAQVNAHVDEAEKEARLRELSSKLEPKSQVKMTSGRVFRRE-DMLQGKRKLLHEGML 316

  Fly   464 --------------------------------------SSLSRGPRIKRNLKLPPGSVGIPELA- 489
                                                  :||...|.:...|||........|.|
Zfish   317 NWRVTNNKGKGDKHTDVIVLLLSDVLLLLLEKDSRLTFASLDGKPAVISLLKLIVREAAHNEKAM 381

  Fly   490 -IVSEELKTPTSEEQAKKPKSVQNESQPNHPEELNQSNDKPSDELDLIMG-EEGDEEELRQK--- 549
             ::|..|.||.           ..|...:..||.|...:|....::.... :|.:.|||.:|
Zfish   382 FLISASLDTPE-----------MYEFHTSSAEERNTWTNKIWKAVECCPDVKEEEPEELSKKIWE 435

  Fly   550 -QRK---HKYASI----YEKLRF--------TFAKGRKSASPSPTKAQIREEVS---------ID 589
             |||   |. |||    .|||:.        |......::...|.:....|.:.         .|
Zfish   436 FQRKLCVHD-ASIEQHLTEKLKLFSSIAASVTGVSDTSTSERHPLRGNAAEPLQGERLLTGALKD 499

  Fly   590 EESIK------DSTSEDMVTRKEDFTLDLPKEVIPRAEDLEDSSHALLVSPCFEADAKILDALEA 648
            .|:::      :.......:|..|..|..|..|    ..||:::| :|....||:      ::|:
Zfish   500 VENLQNLLVMCEQGPTPFTSRATDLVLKKPHAV----TGLENNTH-MLPENGFES------SMES 553

  Fly   649 VDLKLKVLNPLNDVTTADGE-RELLLAANDDF--EQRI---LPNSSF---VYQAANKQYSNNQIL 704
            :..:::|.|     |..|.: |||.|:.|.:.  ::.:   .|.:.|   |.|.:.|.||...::
Zfish   554 MGDRIQVAN-----TDLDPQLRELHLSENQELSADENLSVHFPKAEFYSTVSQLSRKLYSLQSVV 613

  Fly   705 LNQAVNVTLVNA--------------IEGE--------------------QMIMEQKQ------- 728
            .....::.:.:|              :|.|                    |.:.||:|
Zfish   614 QQLESHIKVQHATIEELKSRPRGNSLLEQEKHRNLHKQNEELANFQRLQNQRLQEQRQWEQERER 678

  Fly   729 ---LMKVRDLELTERDI------------DQPLKRAEKSPEKDDTLEPESLYEPITPVMDETKTE 778
               ..:.|:.||.||::            .|.|.|..:..::|        .|.:...|...:.|
Zfish   679 QMLQAEAREKELREREMACSRQEEMLAGEKQELARCREEYQQD--------LERLRESMRSVEKE 735

  Fly   779 AQTSSLFKIYTKKSELVEDIYQTVEEASTVEVKPNNWLEGYESIAGSQEACPLTYDGYESFAPEE 843
            .:...|.|.| ||:|.|..:|..  |...:::.|            ......:...|:...||
Zfish   736 KEKLELQKKY-KKNENVPVVYPL--ENEQIQIPP------------PYPILNIVSPGFTERAP-- 783

  Fly   844 VVTTPTTPSATGTLGRNTRDELPELP-----------KPKRVLNKSPIPLRPAPPKPQAKESEED 897
             :..|...|.||:|.:      ||:|           |...|..|.|..| .|.||.:.|.|:
Zfish   784 -LVPPRRESITGSLVK------PEVPIHLISTTNQTLKAGSVQQKIPTKL-AAQPKGKEKHSK-- 838

  Fly   898 ENIYDTIKGCYESMHCKATSSSSSGEATLTTDTISLSSNCYESISHIRRSRVATTQNQGHGSAGS 962
                      :.:.| :.|:|::..|                 :||:...:||       |..|.
Zfish   839 ----------HRNSH-QRTNSAAGIE-----------------VSHVVPIKVA-------GREGG 868

  Fly   963 CI--------------------QLSSSGSTLTISSDHKTNSLYES 987
            .:                    :||||.|:.:.:|..|.|..:.|
Zfish   869 SLKAIRSSSPHHLHPDLFTHPDKLSSSVSSHSGNSSRKHNHSHNS 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015
		PH_ephexin	1805..1931	CDD:269929
		SH3_ephexin1_like	1944..1998	CDD:212727
arhgef18a	NP_999983.1	RhoGEF	74..266	CDD:279015	52/270 (19%)
		PH-like	307..427	CDD:302622	18/130 (14%)
		DUF4200	650..747	CDD:290574	19/105 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900