Protein Alignment Exn and CG42674

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Alignment Length: 1731
• Identity: 318/1731 - (18%)
• Similarity: 508/1731 - (29%)
• Gaps: 656/1731 - (37%)

  Fly   481 GSVGIPELAIVSEELKTPTSEEQAKKP--------KSVQNESQPNHPEELNQSNDKPSDELDLIM 537
            |....|.:.:.|.:  .|.:.:|.:.|        |.::.|.:......|.:|.|||
  Fly     3 GGFAAPPITLASNQ--RPVALDQVEIPIPATDMHEKLLEKEGKTERTNLLGRSKDKP-------- 57

  Fly   538 GEEGDEEELRQKQRKHKYASIYEKLRFTFAKGRKSASPSPTKAQIREEVSIDEESIKDSTSEDMV 602
                      .|.:..|.:...|:||.:|.:|                   |..|::       :
  Fly    58 ----------PKDKPPKQSKFAERLRRSFRRG-------------------DHRSLE-------I 86

  Fly   603 TRKEDFTLDLPKEVIPRAEDLEDSSHALLVSPCFEADAKILDALEAVDLKLKVLNPLNDVTTADG 667
            .|:|           |..|:|:..|.|   :|                       |......:|.
  Fly    87 KRQE-----------PTPEELKAKSRA---TP-----------------------PPPSTLRSDN 114

  Fly   668 ERELLLAANDDFEQRILPNSSFVYQAANKQYSNNQILLNQAVNVTLVNAIEGEQMIMEQKQLMKV 732
            ...|..|    .....||............:.|..:||
  Fly   115 NNRLPFA----LSHLNLPGLGLGVGVGVGGHINPALLL--------------------------- 148

  Fly   733 RDLELTERDIDQPLKRAEKSPEKDDTLEPESLYEPITPVMDETKTEAQTSSLFKIYTKKSELVED 797
                      |.|          |:...||..|:.::.|.....:.:..||        .||.|
  Fly   149 ----------DSP----------DECTPPEYAYQHLSSVATTNSSTSLESS--------CELGE- 184

  Fly   798 IYQTVEEASTVEVKPNNWLEGYESIAGSQEACPLTYDGYESFAPEEVVTTPTTPSATGTLGRNTR 862
                                    ::|||.:   .|  |.:....||.|:.....|.||.|....
  Fly   185 ------------------------LSGSQNS---VY--YWASMGGEVSTSAGAAGADGTAGTGAG 220

  Fly   863 D------ELPELPKPKRVL---NKSPIPLRPAPPKPQAKESEEDENIYDTIKGCYESMHCKATSS 918
            .      .:|...:.:|.|   |.|....:|......:....             .|..|..||.
  Fly   221 TGAGAGAAVPIEGQDRRRLETQNSSRSDQQPITTNASSAPGN-------------SSRSCSLTSD 272

  Fly   919 SSSGEATLTTDTISLSSNCYESISHIRRSRVATTQNQGHGSAGSCIQLSSSGSTLTISSDHKTNS 983
            |||...|...:.:..|||  ||      ||..    |||.:.|           .|:||.:.::.
  Fly   273 SSSIRLTRLQNFLFKSSN--ES------SRSC----QGHSNEG-----------FTVSSHNSSSG 314

  Fly   984 LYESSLAAAGCVVYGSASVGCRSSLGSSAGSRDSGKPGDKRSSIAGSSDNSDAWVDISDGEIGQA 1048
            .:|.    .|..:..|:.||         |..|          ..|.|...::..|.:||.:...
  Fly   315 EWEQ----LGAYLSSSSGVG---------GGHD----------FQGGSFPEESTPDETDGTLPVE 356

  Fly  1049 TTDATANEA--QFIVVRERFKPHRTRSPDWSKRIRDKRLQQKKAISCIEDDSDHYYETLSPLGNK 1111
            |:.:.....  |:.:.    .|:....|:.:.|.......:..|:...|..:|..     .|..|
  Fly   357 TSSSGGGGGYYQYTLT----SPNNPFLPEITARTYHSTYGEDGAVEGGEPTTDDL-----QLDGK 412

  Fly  1112 -----RHSTQLVRQSQDGNRSGGVRSSHRRS--------KNHSASAHTLGEHVVISDDYDSFETD 1163
                 ..|.||...|.  :|:|...|:|...        ...|:|:.|.|.|
  Fly   413 YGCAGSRSAQLPTPSY--SRAGSQESTHSEGGGPPGPTPSPASSSSSTPGRH------------- 462

  Fly  1164 SDDHGDGEPDLRQRNYN-DSGVDMRNHRLPKPP--------PPQN-----------QVYEFVRKF 1208
                       |::.:: :|...:.:|:..:||        ||..           .....||..
  Fly   463 -----------RRKLFSLNSPTRLLHHQQQQPPPSGATSASPPSGGSSNDGGGGKFNSASLVRSL 516

  Fly  1209 KDFISSKKSPKGSQQKLYENTPASTLFYVECSKRTEDVYENTDFGPERIPAPETKGPVHQEQAPV 1273
            ..|:.|..|||.:..|....|....|                                    .|.
  Fly   517 NPFLPSVTSPKKAPHKQSAVTSPGCL------------------------------------TPD 545

  Fly  1274 LRAKQKNGKSLRSRLRKSLVGSSFDTK-QLSSLAPTRSTFYVEDPEGSLPALPLEP--------- 1328
            |..|::  :.||:.::..||.|..::| ||.|    :|..:::..:..:.|....|
  Fly   546 LSTKRE--EFLRATMKICLVVSPPNSKLQLKS----KSLTHLDGLDSGVVACQQGPPGMATSTAS 604

  Fly  1329 ----EIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPP---- 1385
                ...|:|.....|:   .|..|     .::.|:|....|.  .||.:.|.|:.|.|..
  Fly   605 TTATTAGGTGATTGLFA---TTGAP-----GSLGRQANVTEKG--ERTGVCLSPSAPQPSSHASP 659

  Fly  1386 --PPMTGNKSP----------LDPERELDAEQTTSWYAEC--------GVFKQ--------ATNG 1422
              ||....::|          |.|  .|| |.||:..:.|        |.|.|        ...|
  Fly   660 HHPPTIYTQAPQVVRRMPSLMLSP--TLD-ETTTTASSSCFGTGHPSAGSFHQHQHHHHHHQPTG 721

  Fly  1423 AVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSS------------GVSTGNEAG 1475
            :|| ......|.|.|.|...||.:     :|:.|.:.|:||.|:            |...|..||
  Fly   722 SVS-TASCTATSTTSTHAVPSSKH-----FQSVGEAAATSSSSTLSPHSATSATLGGGGGGGGAG 780

  Fly  1476 LG---------------------------------DELSSEPHSL-----FSNEPLYQMYSAAK- 1501
            .|                                 :..|||..|:     .|.:|..:...|.|
  Fly   781 GGGLTSPVGCSTSSGSTVKKKSSFMKRKKPLLTRSEVSSSEFFSVSFCLDSSQQPDEEFIPATKG 845

  Fly  1502 ---LESITRDLEAHGSS---------------------------------------------DGY 1518
               |.:::..|.....|                                             .|.
  Fly   846 VTLLNALSHALRRRNLSFTQITITDNNPTPSFLDAGPSLLPVSVDEQTDVESLAGHHLCITERGS 910

  Fly  1519 EEIGLQAKA-----KPEPLVKP-----------------------------RPTALQLVE----- 1544
            ....||..|     :|.|.:.|                             .|...||.|
  Fly   911 NRKPLQKAASFGSRQPPPRLLPSVSTEETSESGVAPGKQIKQRWSSIFGIKNPQQSQLCELLNSY 975

  Fly  1545 PKNG-PSR--TLWSEIPEVIHSCIL--------------PTLTSRERSLQEAKFEIITSEASYLK 1592
            .||| |.|  ::..:.|::::|...              .:::..|..:|.|.:|::|:|..|:.
  Fly   976 AKNGVPQRPDSMSFDHPDLVNSLAYLQYMHKSWRDFVNSDSMSESEVKIQTAIWELVTTEVYYIH 1040

  Fly  1593 SLNLLRRHFMN-HNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCI 1656
            :|..:...|:. ..|..:..:|...|:..|||.:..|.|.:.:..|            |.|...:
  Fly  1041 ALQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAVCEANIKFWT------------LWLYPMV 1093

  Fly  1657 YEIAERH------------------FHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEAS 1703
            ...|..|                  |..|..:|..|.......:.|..:  :..|..:|...|:.
  Fly  1094 AHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHN--NALFTSYLAWCESQ 1156

  Fly  1704 PSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRW 1768
            ..|..|.|...::.||||:|:..||:.|:  |:...:.||.|:..:.:..|:..||..|......
  Fly  1157 KMCNRLRLADIVVRPMQRLTKYSLLLAAI--KKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMR 1219

  Fly  1769 EQAFELERIARQLEFPSHV------------RALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGE 1821
            ::...|:.:..::|....|            :...:..:..|..|. |.:.|:     ||...|:
  Fly  1220 QENERLKGVMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGC-PAYHVR-----HLFMEGD 1278

  Fly  1822 DAKLTFGKRLTKISIYAFLFSDLLLLCK---RRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDL 1883
            .   .|...|.|..::.||.:||||:||   :||.....|.              ..|.|..:.:
  Fly  1279 H---KFKDNLGKSDVHCFLLTDLLLVCKTIAKRGLGALKVI--------------RQPYLTDQLI 1326

  Fly  1884 KDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAM 1924
            ...|..|.:....|......|....|.|   ::.:.|..|:
  Fly  1327 VQLAPNNTLNCVYLNEFQVATTAFTLQC---TEAKNWYDAL 1364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	45/200 (23%)
		PH_ephexin	1805..1931	CDD:269929	28/123 (23%)
		SH3_ephexin1_like	1944..1998	CDD:212727
CG42674	NP_649182.4	RhoGEF	1027..1213	CDD:279015	46/201 (23%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	27/119 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810